The Silicon Photomultiplier for application to high-resolution Positron Emission Tomography

Herbert, D.; Moehrs, Sascha; D’Ascenzo, N.; Belcari, Nicola; Guerra, A. Del; Morsani, F.; Saveliev, V.

doi:10.1016/j.nima.2006.11.020

Cited by 48 publications

(27 citation statements)

References 4 publications

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“…APDs are available as arrays of sensors as well as positionsensitive planar devices (PS-APD) where signals from the four corners of the device are used to determine the position of an event [12]. The Geiger-mode APD, or silicon photomultiplier (SiPM), is another widely studied photosensor in novel PET research [14,15].…”

Section: Beyond the Block Designmentioning

confidence: 99%

“…Similar geometries, using LSO detectors in a ring insert, have been studied by the same group in application to whole body clinical scanners. Simulation studies have demonstrated the possibility of improved spatial resolution in this context [14]. A prototype system, based on a Siemens Biograph-40 clinical PET-CT scanner and a half-ring insert composed of high-resolution LSO detectors has been constructed [15] and shown to benefit image resolution and contrast [15,16].…”

Section: Existing Systemsmentioning

confidence: 99%

“…Lower energy interactions create a signal which takes a longer time to rise to the trigger threshold. The depth-related broadening is due to a similar effect, but here rise-time is dependent on the depth at which the interaction occurs in the detector [14]. Finally, electronic jitter is noise due to detector electronics.…”

Section: Timing and Energymentioning

confidence: 99%

“…A resolution of 10 ns FWHM was modeled as a conservative estimate taken from the results of the aforementioned simulation study [14]. In chapter 4 of this work, a study is performed to observe the effects of the CTW.…”

Section: Timing and Energymentioning

confidence: 99%

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Study of a high-resolution PET system using a Silicon detector probe

et al. 2014

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A high-resolution silicon detector probe, in coincidence with a conventional PET scanner, is expected to provide images of higher quality than those achievable using the scanner alone. Spatial resolution should improve due to the finer pixelization of the probe detector, while increased sensitivity in the probe vicinity is expected to decrease noise. A PET-probe prototype is being developed utilizing this principle. The system includes a probe consisting of ten layers of silicon detectors, each a 80 × 52 array of 1 × 1 × 1 mm 3 pixels, to be operated in coincidence with a modern clinical PET scanner. Detailed simulation studies of this system have been performed to assess the effect of the additional probe information on the quality of the reconstructed images. A grid of point sources was simulated to study the contribution of the probe to the system resolution at different locations over the field of view (FOV). A resolution phantom was used to demonstrate the effect on image resolution for two probe positions. A homogeneous source distribution with hot and cold regions was used to demonstrate that the localized improvement in resolution does not come at the expense of the overall quality of the image. Since the improvement is constrained to an area close to the probe, breast imaging is proposed as a potential application for the novel geometry. In this sense, a simplified breast phantom, adjacent to heart and torso compartments, was simulated and the effect of the probe on lesion detectability, through measurements of the local contrast recovery coefficient-to-noise ratio (CNR), was observed. The list-mode ML-EM algorithm was used for image reconstruction in all cases. As expected, the point spread function of the PETprobe system was found to be non-isotropic and vary with position, offering improvement in specific regions. Increase in resolution, of factors of up to Institute of Physics and Engineering in Medicine

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Section: Beyond the Block Designmentioning

confidence: 99%

Section: Existing Systemsmentioning

confidence: 99%

Section: Timing and Energymentioning

confidence: 99%

Section: Timing and Energymentioning

confidence: 99%

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Study of a high-resolution PET system using a Silicon detector probe

et al. 2014

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“…However, silicon photomultipliers (SiPMs) are turning into a promising alternative for PMTs, as of recently (Antich et al 1997, Bondarenko et al 2000, Britvitch et al 2007, Golovin and Saveliev 2004, Herbert et al 2007, Lewellen 2008, McElroy et al 2007, Renker 2007, Yamamoto et al 2007. Similar to PMTs, SiPMs have a gain in the order of ∼10 6 .…”

Section: Introductionmentioning

confidence: 99%

LaBr₃:Ce and SiPMs for time-of-flight PET: achieving 100 ps coincidence resolving time

et al. 2010

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The use of time-of-flight (TOF) information in positron emission tomography (PET) enables significant improvement in image noise properties and, therefore, lesion detection. Silicon photomultipliers (SiPMs) are solid-state photosensors that have several advantages over photomultiplier tubes (PMTs). SiPMs are small, essentially transparent to 511 keV gamma rays and insensitive to magnetic fields. This enables novel detector designs aimed at e.g. compactness, high resolution, depth-of-interaction (DOI) correction and MRI compatibility. The goal of the present work is to study the timing performance of SiPMs in combination with LaBr 3 :Ce(5%), a relatively new scintillator with promising characteristics for TOF-PET. Measurements were performed with two, bare, 3 mm × 3 mm × 5 mm LaBr 3 :Ce(5%) crystals, each coupled to a 3 mm × 3 mm SiPM. Using a 22 Na point source placed at various positions in between the two detectors, a coincidence resolving time (CRT) of ∼100 ps FWHM for 511 keV annihilation photon pairs was achieved, corresponding to a TOF positioning resolution of ∼15 mm FWHM. At the same time, pulse height spectra with well-resolved full-energy peaks were obtained. To our knowledge this is the best CRT reported for SiPM-based scintillation detectors to date. It is concluded that SiPM-based scintillation detectors can provide timing resolutions at least as good as detectors based on PMTs.

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Molecular Imaging and Instrumentation

Shaikh

2022

Advances in Imaging

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The Silicon Photomultiplier for application to high-resolution Positron Emission Tomography

Cited by 48 publications

References 4 publications

Study of a high-resolution PET system using a Silicon detector probe

Study of a high-resolution PET system using a Silicon detector probe

LaBr₃:Ce and SiPMs for time-of-flight PET: achieving 100 ps coincidence resolving time

Molecular Imaging and Instrumentation

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The Silicon Photomultiplier for application to high-resolution Positron Emission Tomography

Cited by 48 publications

References 4 publications

Study of a high-resolution PET system using a Silicon detector probe

Study of a high-resolution PET system using a Silicon detector probe

LaBr3:Ce and SiPMs for time-of-flight PET: achieving 100 ps coincidence resolving time

Molecular Imaging and Instrumentation

Contact Info

Product

Resources

About

LaBr₃:Ce and SiPMs for time-of-flight PET: achieving 100 ps coincidence resolving time