The Silver, Cobalt, Chromium, Iron, Mercury, Rubidium, Antimony, Selenium, And Zinc Contents In Human Bone Affected By chondrosarcoma

Abstract

Objectives: To clarify the role of trace elements in the etiology and the pathogenesis of the chondrosarcoma, a non-destructive neutron activation analysis with high resolution spectrometry of long-lived radionuclides were performed. Methodology:The silver (Ag), cobalt (Co), chromium (Cr), iron (Fe), mercury (Hg), rubidium (Rb), antimony (Sb), selenium (Se), and zinc (Zn) mass fractions and Co/Zn, Cr/Zn, Fe/Zn, Hg/Zn, Sb/Zn, Co/Rb, Cr/Rb, Fe/ Rb, Hg/Rb, Sb/Rb, and Se/Rb mass fraction ratios were estimated in normal bone samples from 27 patients with intact bone (12 females and 15 males, aged from 16 to 49 years), who had died from various non bone related causes, mainly unexpected from trauma, and in tumor samples, obtained from open biopsies or after operation of 16 patients with chondrosarcoma ((3 females and 13 males, 8 to 65 years old). The reliability of difference in the results between intact bone and chondrosarcoma tissues was evaluated by Student's t-test. Key results:In the chondrosarcoma tissue the mass fractions of Co, Fe, and Se are significantly higher while the mass fraction of Rb is lower than in normal bone tissues. Moreover, significantly higher Co/Zn, Fe/Zn, Co/ Rb, Cr/Rb, Fe/Rb, Sb/Rb, and Se/Rb mass fraction ratios are typical of the chondrosarcoma tissue compared to intact bone. In the chondrosarcoma tissue many correlations between trace elements found in the control group was no longer evident. Major conclusions:In chondrosarcoma transformed bone tissues the trace element homeostasis is significantly disturbed.

Significance of Trace Element Quantities in Osteomyelitis and Ewing's Sarcoma

“…A high Se level was reported in malignant tumors of the ovary [58], lung [59], prostate [60][61][62][63][64][65][66][67][68], breast [69,70], gastro intestinal tract [71], and also in cancers of the stomach [72] and thyroid [73]. Moreover, in our previous study elevated levels of Se were found in such malignant tumors of bone as osteogenic sarcoma [74], chondrosarcoma [75], and malignant giant cell tumor of bone [76]. The role played by Se in those tumors remains unknown, but in general it is accepted that certain proteins containing Se can mediate the protective effects against oxidative stress.…”

Significance of Trace Element Quantities in Osteomyelitis and Osteosarcoma

“…A high Se level was reported in malignant tumors of the ovary [59], lung [60], prostate [61][62][63][64][65][66][67][68][69], breast [70,71], gastro intestinal tract [72], and also in cancers of the stomach [73] and thyroid [74]. Moreover, in our previous study elevated levels of Se were found in such malignant tumors of bone as Ewing's sarcoma [75], chondrosarcoma [76], and malignant giant cell tumor of bone [77]. The role played by Se in those tumors remains unknown, but in general it is accepted that certain proteins containing Se can mediate the protective effects against oxidative stress.…”

Twenty Chemical Element Contents in Normal and Cancerous Thyroid

“…water volume, including the blood volumes, in tissues [79]. Cancerous tissues are predominantly highly vascularized lesions [80][81][82][83][84][85]. Thus, it is possible to speculate that thyroid malignant tumors are characterized by an increase of the mean value of the Cl mass fraction because the level of tumor vascularization is higher than that in normal thyroid tissue.…”