The similarity of the structure of DSM-IV criteria for major depression in depressed women from China, the United States and Europe

Kendler, Kenneth S.; Aggen, Steven H.; Li, Y.; Lewis, Cathryn M.; Breen, Gerome; Boomsma, Dorret I.; Bot, Mariska; Penninx, Brenda W. J. H.; Flint, Jonathan

doi:10.1017/s0033291714003067

Cited by 27 publications

(20 citation statements)

References 41 publications

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“…The CONVERGE sample may be imperfectly representative of MD and the anxiety disorders. Results from CONVERGE have been largely consistent with MD results from other populations, however 26, 27 , so the present analysis is expected to be generalizable to MD and comorbid anxiety disorders in other populations. The logistic regressions were unadjusted for demographic characteristics, but since the sample is largely homogenous (same ethnicity, same sex, and relatively limited age range), it’s probable that this biased the estimates minimally.…”

Section: Discussionsupporting

confidence: 69%

Classification of Anxiety Disorders Comorbid With Major Depression: Common or Distinct Influences on Risk?

2015

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Background Anxiety and depression display frequent comorbidity. Individuals with comorbid disorders also often have more extreme symptomatology than those with single disorders. This correlation between comorbidity and severity poses an interesting question: are comorbid forms of anxiety and depression essentially just more severe versions of the pure disorders? Methods In a large major depression case-control sample of individuals from the CONVERGE project, we examined the patterns of lifetime anxiety comorbidity (including generalized anxiety disorder – GAD, panic disorder and five phobia subtypes) among major depression (MD) cases (N=5,864) in this population. Binary and multinomial logistic regression was used to estimate associations between risk factors and outcomes including MD as well as latent class membership, which were compared using continuation ratios. Results We found a five-class solution to fit best, and each resulting class had a distinct pattern of association with the tested risk factors. The use of continuation ratios suggests that a class characterized by high endorsement of GAD is comparable to a more severely affected ‘pure MD’ group. The other three classes (characterized by agoraphobia, various specific phobias, and by high endorsement of all comorbid anxiety disorders, respectively) appear to differ meaningfully from MD alone. Conclusions Risk for MD resulting from environmental and psychosocial factors may also predispose individuals to GAD, and less consistently, other anxiety disorders. Presentations of MD with certain phobias display distinguishably different patterns of risk, however, and are therefore likely qualitatively distinct.

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Section: Discussionsupporting

confidence: 69%

Classification of Anxiety Disorders Comorbid With Major Depression: Common or Distinct Influences on Risk?

2015

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“…40 Previous research on structural invariance of MD measurement has been reported elsewhere, indicating that the DSM criteria perform similarly in this sample relative to European and U.S. samples. 41 Representativeness of the sample with regard to severity, chronicity, and number of depressive episodes has also been reported previously, and the mean illness duration of this sample was 9.75 years. 42 …”

Section: Methodssupporting

confidence: 74%

“…Diagnoses of depressive disorders were completed using the (Kendler et al, 2015). Representativeness of the sample with regard to severity, chronicity, and number of depressive episodes has also been reported previously, and the mean illness duration of this sample was 9.75 years (Li et al, 2012).…”

Section: Sample Ascertainmentmentioning

confidence: 77%

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Age of onset and family history as indicators of polygenic risk for major depression

et al. 2017

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Background The extent to which earlier age of onset (AO) is a reflection of increased genetic risk for major depression (MD) is still unknown. Previous biometrical research has provided mixed empirical evidence for the genetic overlap of AO with MD. If AO is demonstrated to be relevant to molecular polygenic risk for MD, incorporation of AO as a phenotype could enhance future genetic studies. Methods This research estimated the SNP-based heritability of AO in the China, Oxford and VCU Experimental Research on Genetic Epidemiology (CONVERGE) case-control sample (N = 9854, MD case n = 4,927). Common SNP heritability of MD was also examined across both high and low median-split AO groups, and best linear unbiased predictor (BLUP) scores of polygenic risk, in split-halves, were used to predict AO. Distributions of genetic risk across early and late AO were compared, and presence of self-reported family history of MD was also examined as a predictor of AO. Results AO was not significantly heritable and polygenic risk derived from the aggregated effects of common genetic variants did not significantly predict AO in any analysis. AO was modestly but significantly lower in cases with a first-degree genetic family history of MD. Conclusions Findings indicate that AO is associated with greater self-reported genetic risk for MD in cases, yet not associated with common variant polygenic risk for MD. Future studies of early MD may benefit more from the examination of important moderating variables such as early life events.

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“…Previous research on structural invariance of MDD measurement has been reported elsewhere, indicating that the DSM criteria perform similarly in this sample relative to European and U.S. samples (Kendler et al 2015). …”

Section: Methodsmentioning

confidence: 51%

Polygenic risk for severe psychopathology among Europeans is associated with major depressive disorder in Han Chinese women

et al. 2017

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Background Previous studies have demonstrated that several major psychiatric disorders are influenced by shared genetic factors. This shared liability may influence clinical features of a given disorder (e.g. severity, age at onset). However, findings have largely been limited to European samples; little is known about the consistency of shared genetic liability across ethnicities. Method The relationship between polygenic risk for several major psychiatric diagnoses and major depressive disorder (MDD) was examined in a sample of unrelated Han Chinese women. Polygenic risk scores (PRSs) were generated using European discovery samples and tested in the China, Oxford, and VCU Experimental Research on Genetic Epidemiology [CONVERGE (maximum N = 10 502)], a sample ascertained for recurrent MDD. Genetic correlations between discovery phenotypes and MDD were also assessed. In addition, within-case characteristics were examined. Results European-based polygenic risk for several major psychiatric disorder phenotypes was significantly associated with the MDD case status in CONVERGE. Risk for clinically significant indicators (neuroticism and subjective well-being) was also associated with case–control status. The variance accounted for by PRS for both psychopathology and for well-being was similar to estimates reported for within-ethnicity comparisons in European samples. However, European-based PRS were largely unassociated with CONVERGE family history, clinical characteristics, or comorbidity. Conclusions The shared genetic liability across severe forms of psychopathology is largely consistent across European and Han Chinese ethnicities, with little attenuation of genetic signal relative to within-ethnicity analyses. The overall absence of associations between PRS for other disorders and within-MDD variation suggests that clinical characteristics of MDD may arise due to contributions from ethnicity-specific factors and/or pathoplasticity.

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The similarity of the structure of DSM-IV criteria for major depression in depressed women from China, the United States and Europe

Cited by 27 publications

References 41 publications

Classification of Anxiety Disorders Comorbid With Major Depression: Common or Distinct Influences on Risk?

Classification of Anxiety Disorders Comorbid With Major Depression: Common or Distinct Influences on Risk?

Age of onset and family history as indicators of polygenic risk for major depression

Polygenic risk for severe psychopathology among Europeans is associated with major depressive disorder in Han Chinese women

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