The simulation of multiphase flow field in implantable blood pump and analysis of hemolytic capability

Li, Tieyan; Liang, Y. T.; Hong, Fang-wen; Liu, Deng-Cheng; Fan, Huimin; Liu, Zhongmin

doi:10.1016/s1001-6058(11)60402-3

Cited by 13 publications

(15 citation statements)

References 14 publications

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Section: Introductionmentioning

confidence: 99%

“…Continuous-flow cardiac assist pumps have been successfully used to treat end-stage heart failure patients as destination therapy, bridge-to-transplantation or bridgeto-recovery [1][2][3]. However, hemolysis reduction is still a significant design challenge for blood pumps [2,3]. Even though the impeller geometry plays an essential role in the overall performance of a centrifugal blood pump [4], the volute structure is equally critical for assuring steady flow lines and good kinetic energy to potential energy conversion for achieving greater hydraulic performance and a lower hemolysis risk [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Computational fluid dynamics (CFD) has been broadly used for the design and optimization of rotary blood pumps [9][10][11]. This method is a reliable technique to investigate the overall flow characteristics, and to simplify the development period of the device, reducing the time and cost of experimentation [2,3]. As the blood damage potential has recently been incorporated into these CFD analyses, various numerical models have been adopted by several research groups to estimate the hemolysis and optimize the design of rotary blood pumps [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Numerical investigation of volute tongue design on hemodynamic characteristics and hemolysis of the centrifugal blood pump

2021

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In the design of rotary blood pumps, the optimization of design parameters plays an essential role in enhancing the hydrodynamic performance and hemocompatibility. This study investigates the influence of the volute tongue angle as a volute geometric parameter on the hemodynamic characteristics of a blood pump. A numerical investigation on five different versions of volute designs is carried out by utilizing a computational fluid dynamics (CFD) software ANSYS-FLUENT. The effect of volute tongue angle is evaluated regarding the hydrodynamic performance, circumferential pressure distribution, the radial force, and the blood damage potential. A series of volute configurations are constructed with a fixed radial gap (5%), but varying tongue angles ranging from 10 to 50°. The relative hemolysis is assessed with the Eulerian based empirical power-law blood damage model. The pressure-flow rate characteristics of the volute designs at a range of rotational speeds are obtained from the experimental measurements by using the blood analog fluid. The results indicate an inverse relationship between hydraulic performance and the tongue angle; at higher tongue angles, a decrease in performance was observed. However, a higher tongue angle improves the net radial force acting on the impeller. The pump achieves the optimized performance at 20° of the tongue angle with the relatively high hydrodynamic performance and minor blood damage risk.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Numerical investigation of volute tongue design on hemodynamic characteristics and hemolysis of the centrifugal blood pump

2021

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“…According to the analysis of [10][11][12][13][14][15][16][17][18], the finite element method has advantages in calculation accuracy and reliability compared with other methods. Considering the design requirements and the feasibility of the calculation process, the design variables are a series of discrete variable values.…”

Section: Introductionmentioning

confidence: 99%

A Study on the Influencing Factors and Optimization Design of Combined Push‐Pull Magnetic Drive Coupling

Gao

Chaoqun

Feng

et al. 2019

Mathematical Problems in Engineering

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In order to study the effect of geometrical parameters of magnetic drive coupling on magnetic torque and magnetic eddy current loss, based on the basic theory of electromagnetic field, the influence factors of magnetic performance of combined push-pull magnetic drive coupling are analyzed and optimized by means of finite element numerical calculation and orthogonal experiment. The optimal geometrical parameter scheme of magnetic drive coupling was obtained, and the magnetic performance of the optimal geometrical parameter model was studied experimentally. The geometrical parameters of the optimal scheme of magnetic drive coupling are internal radius of magnet r = 80 mm, thickness of permanent magnet tm = 8 mm, axial length Lb = 144 mm, and thickness of yoke iron ti = 10 mm. The research shows that the optimization design method proposed in this paper is reliable in the design of magnetic drive coupling and can provide some theoretical reference for the design of magnetic drive coupling and the optimization of magnetic torque and magnetic eddy current loss.

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“…Fraser et al investigated the effect of shear stress and exposure time on hemolysis index in centrifugal and axial ventricular assist devices (VADs) numerically, and the results showed hemolysis in axial VADs was higher; finally, they concluded that the reason for the increase of hemolysis was longer exposure time at higher shear stress. Li et al simulated the flow field and hemolysis of an axial flow blood pump employing a multiphase model, in which shear stress distribution was used to evaluate hemolysis and a qualitative hemolysis model was proposed; moreover, hemolysis experimental validation was conducted using bovine blood.…”

mentioning

confidence: 99%

Investigation of High‐Speed Erythrocyte Flow and Erythrocyte‐Wall Impact in a Lab‐on‐a‐Chip

Zheng

Zhang

et al. 2016

Artificial Organs

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To better understand erythrocyte high-speed motion, collision characteristics, and collision-induced hemolysis probability in rotary blood pumps, a visual experimental investigation of high-speed erythrocyte flow and erythrocyte-wall collision in a lab-on-a-chip was performed. The erythrocyte suspension was driven by a microsyringe pump connected to the microchip, and the erythrocyte flow and erythrocyte-wall impact process were observed and imaged by an optical microscope and a high-speed camera. Two types of microchips with different impact surfaces (flat and curved) were employed. The motion and deformation features before and after collision were studied in detail. The results show that erythrocytes not only move along the flow direction in the flow plane but also rotate and roll in three-dimensional space. Erythrocytes keep discoid shape during the movement in the straight channel, but their deformations during collision are mainly classified into two types: erythrocyte structure is still stable and the erythrocyte performance can be ensured to a certain extent in the TypeA deformation, while the TypeB deformation makes the membrane more likely to fracture on the stretched side, increasing the probability of hemolysis. Furthermore, the movements and deformations of the erythrocytes after collision are analyzed and classified into two types: bouncing and slipping. Moreover, a simulation method for the flow in microchip was performed and validated through a comparison of the streamlines and experimental erythrocytes tracks, which can be further employed to predict the high-speed blood flow, associated with collision process in mechanical blood pump.

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The simulation of multiphase flow field in implantable blood pump and analysis of hemolytic capability

Cited by 13 publications

References 14 publications

Numerical investigation of volute tongue design on hemodynamic characteristics and hemolysis of the centrifugal blood pump

Numerical investigation of volute tongue design on hemodynamic characteristics and hemolysis of the centrifugal blood pump

A Study on the Influencing Factors and Optimization Design of Combined Push‐Pull Magnetic Drive Coupling

Investigation of High‐Speed Erythrocyte Flow and Erythrocyte‐Wall Impact in a Lab‐on‐a‐Chip

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