The simultaneous assessment of glycosylated hemoglobin, fasting plasma glucose and oral glucose tolerance test does not improve the detection of type 2 diabetes mellitus in Colombian adults

López‐López, José; Garay, Jennifer; Wandurraga-Sánchez, Edwin Antonio; Camacho, Paul Anthony; Higuera-Escalante, Fernando; Cohen, Daniel D.; López‐Jaramillo, Patricio

doi:10.1371/journal.pone.0194446

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Lopez-Lopez et al [37] investigated the effect of simultaneously measuring HbA1c, fasting glucose values and a 2-hour glucose values in detecting new T2DM. They concluded that measuring both fasting and 2-hour glucose values showed the highest proportion of patients with new T2DM.…”

Section: Discussionmentioning

confidence: 99%

Dysglycemia and increased left ventricle mass in normotensive patients admitted with a first myocardial infarction: prognostic implications of dysglycemia during 14 years of follow-up

Pararajasingam

Løgstrup

Høfsten

et al. 2019

BMC Cardiovasc Disord

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Background Left ventricle mass (LVM) can be influenced by various conditions including hypertension and/or inherent cardiomyopathies. Dysglycemia is also thought to exert an anabolic effect on heart tissue by hyperinsulinemia and thereby promoting increased LVM. The primary aim of this study was to assess the influence of dysglycemia on LVM evaluated by an oral glucose tolerance test (OGTT) in patients admitted with a first myocardial infarction (MI) without hypertension. The secondary aim was to assess the impact of dysglycemia on major adverse cardiovascular events (MACE) and all-cause mortality during long-term follow-up. Methods Patients admitted with a first MI without known history of hypertension were included. All patients without previously known type 2 diabetes mellitus (T2DM) had a standardized 2-hour OGTT performed and were categorized as: normal glucose tolerance (NGT), impaired fasting glucose (IFG)/impaired glucose tolerance (IGT) and newly detected T2DM (new T2DM). LVM was measured by echocardiography using Devereaux formula and indexed by body surface area. Multivariate linear regression analysis was used to assess the impact of confounders (dysglycemia by OGTT, known T2DM, age, sex and type of MI) on LVM. Cox proportional hazard model was used to assess the impact of dysglycemia on all-cause mortality and a composite endpoint of MACE (all-cause mortality, MI, revascularisation due to stable angina, coronary artery bypass graft, ischemic stroke or hemorrhagic stroke). Results Two-hundred-and-five patients were included and followed up to 14 years. In multivariate regression analysis, LVM was only significantly increased in patients categorized as new T2DM (β = 25.3; 95% CI [7.5–43.0]) and known T2DM (β = 37.3; 95% CI [10.0-64.5]) compared to patients with NGT. Patients with new T2DM showed higher rates of MACE and all-cause mortality compared to patients with IFG/IGT and NGT; however no significantly increased hazard ratio was detected. Conclusions Dysglycemia is associated with increasing LVM in normotensive patients with a first acute myocardial infarction and the strongest association was observed in patients with new T2DM and patients with known T2DM. Dysglycemia in normotensive patients with a first MI is not an independent predictor of neither MACE nor all-cause mortality during long-term follow-up compared to normotensive patients without dysglycemia. Electronic supplementary material The online version of this article (10.1186/s12872-019-1084-5) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Dysglycemia and increased left ventricle mass in normotensive patients admitted with a first myocardial infarction: prognostic implications of dysglycemia during 14 years of follow-up

Pararajasingam

Løgstrup

Høfsten

et al. 2019

BMC Cardiovasc Disord

View full text Add to dashboard Cite

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Is HbA1c a reliable diagnostic marker for diabetes mellitus in patients with iron deficiency anaemia?: A cross sectional study

Sharma¹,

Kalra²,

Arora³

et al. 2020

IJCBR

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The high prevalence of diabetes in the rural population of India required an early and accurate diagnostic tool. There were several techniques standardized and recommended by the American Diabetes Association. Some of the techniques were plasma glucose, oral glucose tolerance test, and HbA1c. The efficacy of HbA1c is questionable in individuals having a low haemoglobin content. This situation is further aggravated due to high anaemic individuals in rural population. This study was therefore designed for analyzing the efficacy of HbA1c in diagnosing diabetes in anaemic individuals. The experiment involves the enrolment of individuals who are diabetic. Further, these individuals were divided into anaemic and non-anaemic individuals. Here, anaemic individuals were termed as cases and non-anaemic individuals were termed as controls. Samples were collected from both the cases and controls and analyzed for fasting plasma glucose, serum iron and direct TIBC, HbA1c levels, and oral glucose tolerance test. The results obtained in this study shows that the HbA1c levels were lower in the anaemic individuals as compared to the non-anaemic diabetic individuals. There was a positive correlation between Hb level and HbA1c level in an individual, thus indicating that an increase in the Hb level will cause an increase in the HbA1c level in diabetic individuals. The study provides a baseline that HbA1c can’t be considered as a reliable tool for diagnosing diabetes in anaemic individuals. Further extensive studies are required to strengthen these findings with respect to a larger population.

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The simultaneous assessment of glycosylated hemoglobin, fasting plasma glucose and oral glucose tolerance test does not improve the detection of type 2 diabetes mellitus in Colombian adults

Cited by 2 publications

References 23 publications

Dysglycemia and increased left ventricle mass in normotensive patients admitted with a first myocardial infarction: prognostic implications of dysglycemia during 14 years of follow-up

Dysglycemia and increased left ventricle mass in normotensive patients admitted with a first myocardial infarction: prognostic implications of dysglycemia during 14 years of follow-up

Is HbA1c a reliable diagnostic marker for diabetes mellitus in patients with iron deficiency anaemia?: A cross sectional study

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