The simultaneous occurrence of livedoid vasculopathy and lymphocytic thrombophilic arteritis in six cases

Kelly, Robert; Gan, Christian; Ting, Sarajane; Manuelpallai, Nicholas; Wee, Edmund

doi:10.1111/ajd.14063

Cited by 2 publications

(2 citation statements)

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“…Increased incidence of serologic markers of thrombophilia has also been noted in both conditions. 1 , 10 The positive prothrombin 20210A heterozygous gene mutation was thus likely to be a pathogenic factor in this case. The presence of a dense vascular lymphocytic inflammation would also suggest that immunologic as well as thrombophilic factors are pathogenic in lymphocytic thrombophilic arteritis, although thrombophilia is a more important target therapeutically.…”

Section: Discussionmentioning

confidence: 71%

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A case of concomitant clinical and histopathologic features of lymphocytic thrombophilic arteritis and livedoid vasculopathy

Gan,

Johnson,

McAulay-Powell

et al. 2023

JAAD Case Reports

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Section: Discussionmentioning

confidence: 71%

“… 9 The simultaneous occurrence of these 2 conditions has also been noted previously in a study of 6 cases. 10 …”

Section: Discussionmentioning

confidence: 99%

A case of concomitant clinical and histopathologic features of lymphocytic thrombophilic arteritis and livedoid vasculopathy

Gan,

Johnson,

McAulay-Powell

et al. 2023

JAAD Case Reports

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Lymphocytic vasculitis in livedoid vasculopathy: A report of 137 cases

Yuan,

Liu,

Ban

et al. 2023

J Cutan Pathol

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BackgroundLivedoid vasculopathy (LV) is characterized by fibrin deposition and thrombosis in the small vessels of the superficial dermis. It is widely recognized as an occlusive disease, which is primarily treated with anticoagulation therapy.MethodsWe retrospectively analyzed the clinical and histopathological characteristics of patients diagnosed with LV at a tertiary dermatology department to explore the characteristics of lymphocytic vasculitis in LV. The frequency of vasculitis and the types of vessels involved were examined based on the diameters and elastic fiber distribution of the involved vessels. In addition, the immunophenotypes of infiltrating lymphocytes were analyzed.ResultsIn a large retrospective series including 358 LV cases, we identified 137 (38.3%) cases of lymphocytic vasculitis. Among them, 48 cases involved medium‐sized vessels, including arterioles and venules, whereas 89 cases involved only small vessels. In addition, 12 cases displayed a segmental distribution of vasculitis. The infiltrating lymphocytes were mainly T cells, with dominant cells stained positive for CD4.ConclusionsLymphocytic vasculitis forms part of the histological spectrum of LV, affecting both medium‐sized and small vessels. It is possible that the occlusion of small vessels may represent a phenomenon secondary to lymphocytic vasculitis.

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The simultaneous occurrence of livedoid vasculopathy and lymphocytic thrombophilic arteritis in six cases

Abstract: Lymphocytic thrombophilic arteritis and livedoid vasculopathy may both present with livedo racemosa and ulceration. We present 6 cases with features of both conditions, raising the possibility that they are either closely linked or are part of a spectrum of the same condition.

Cited by 2 publications

References 7 publications

A case of concomitant clinical and histopathologic features of lymphocytic thrombophilic arteritis and livedoid vasculopathy

A case of concomitant clinical and histopathologic features of lymphocytic thrombophilic arteritis and livedoid vasculopathy

Lymphocytic vasculitis in livedoid vasculopathy: A report of 137 cases

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