The single-nucleotide polymorphism rs743572 of CYP17A1 shows significant association with polycystic ovary syndrome: a meta-analysis

Xu, Xiqiao; Hu, Kaiyue; Shi, Hao; Yu, Yiping; Xu, Jiawei; Sun, Yingpu

doi:10.1016/j.rbmo.2021.06.012

Cited by 7 publications

(7 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The CYP17A1 gene's most extensively examined SNP is rs743572 [10]. This polymorphism produces in two variant genotypes, "CC" and "CT," as a result of the substitution of T for C in the 5′ untranslated region [12] While some researchers noticed the opposite, others ended up to the conclusion that these two CYP17A1 gene variants might be connected to a higher risk of PCOS [11].…”

Section: Discussionmentioning

confidence: 99%

The CYP17A1 single-nucleotide polymorphism rs743572 in Iraqi polycystic ovary syndrome patients

Albedairy,

Aljawad,

AL-Shammari

et al. 2024

Preprint

View full text Add to dashboard Cite

Polycystic ovarian syndrome (PCOS) has been found to be one of the most prevalent endocrine disorders among women of reproductive age. Genetic factors play a crucial role in the pathogenesis of PCOS. CYP17A1 gene coded for (steroid-17-α hydroxylase/17, 20 lyase) is responsible for androgenesis. This study was aimed to investigate the relationship of CYP17A1 polymorphism with polycystic ovarian syndrome susceptibility from Iraqi women. A case-control association study involving 83 healthy participants and 80 PCOS patients was carried out. Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, the restriction endonuclease MSpAI was used to genotype the SNP rs743572 (T/C) polymorphism on genomic DNA. The statistical analysis was conducted to identify the CYP17A1 polymorphism in PCOS. The most frequent genotypes in patients and control were (T/T) and (T/C) respectively, while (T) the most frequent allele in both patients and control. The inheritance of this SNP in PCOS was under codominant, additive and dominant models. Ultimately, it has been demonstrated that the C allele provided protection. The ‘TT’ genotype was associated with PCOS patients. Further studies need to include more samples to find out the effect of this SNP on PCOS patients.

show abstract

Section: Discussionmentioning

confidence: 99%

The CYP17A1 single-nucleotide polymorphism rs743572 in Iraqi polycystic ovary syndrome patients

Albedairy,

Aljawad,

AL-Shammari

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The present study indicates that rs743572 may independently predict AA-related toxicity. Xu and coworkers reported an elevated risk of polycystic ovary syndrome in Caucasian women carrying the rs743572 C/C genotype [ 17 ]. Lower levels of androstenedione and free testosterone have been reported in rs743574-2 C/C subjects [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Abigene, a Prospective, Multicentric Study of Abiraterone Acetate Pharmacogenetics in Metastatic Castration-Resistant Prostate Cancer

et al. 2023

View full text Add to dashboard Cite

Abiraterone acetate (AA) is the first-in-class of drugs belonging to the second-generation of agents inhibiting androgen neosynthesis in advanced prostate cancer. A cumulative experience attests that germinal gene polymorphisms may play a role in the prediction of anticancer agent pharmacodynamics variability. In the present prospective, multicentric study, gene polymorphisms of CYP17A1 (AA direct target) and the androgen transporter genes SLCO2B1 and SLCO1B3 (potential modulators of AA activity) were confronted with AA pharmacodynamics (treatment response and toxicity) in a group of 137 advanced prostate cancer patients treated in the first line by AA. The median follow-up was 56.3 months (95% CI [52.5–61]). From multivariate analysis, rs2486758 C/C (CYP17A1) and PSA (≥10 ng/mL) were associated with a shorter 3-year biological PFS (HR = 4.05, IC95% [1.46–11.22]; p = 0.007 and HR = 2.08, IC95% [1.31–3.30]; p = 0.002, respectively). From a multivariate analysis, the rs743572 (CYP17A1) and performance status were independently associated with significant toxicity (OR = 3.78 (IC95% [1.42–9.75]; p = 0.006 and OR = 4.54; IC95% [1.46–13.61]; p = 0.007, respectively). Host genome characteristics may help to predict AA treatment efficacy and identify patients at risk for toxicity.

show abstract

“…Cytochrome CYP17 can regulate the activities of 17α-hydroxylase and 17, 20 lyase steroids. These two enzymes play an important role in the synthesis of steroid hormones [ 44 ]. Hydroxysteroid dehydrogenases (HSD3Bs and HSD17Bs) belong to the short-chain dehydrogenase/reductase family.…”

Section: Discussionmentioning

confidence: 99%

Dibutyl Phthalate Adsorbed on Multiwalled Carbon Nanotubes Causes Fetal Developmental Toxicity in Balb/C Mice

Qin

Peng

et al. 2023

Toxics

View full text Add to dashboard Cite

This study investigated whether using multiwalled carbon nanotubes (MWCNTs) as a carrier for dibutyl phthalate (DBP) could delay the degradation rate of DBP in mice and increase its estrogen-like interference effect. Pregnant Balb/C mice were divided into four groups and exposed to different treatments via tail-vein injection every 3 days until gestational day 20. The female and male mice were then sacrificed for toxicological study. The results showed that the combination of MWCNTs and DBP resulted in a higher fetal mortality rate than if the mice were exposed to MWCNTs or DBP alone. H&E staining showed that the estrous period of the exposed mice was delayed, the development of oocytes was blocked in the combination group, the number of spermatogenic cells decreased, and the quality of sperm decreased. Our experiment showed that the expression levels of the genes involved in sex hormone synthesis in the testis and ovaries were significantly increased after combined treatment compared with the MWCNT group (p < 0.01). The study suggests that DBP degradation is delayed when absorbed on MWCNTs, which increases its estrogen-like interference and interferes with fetal development, ultimately leading to increased fetal mortality.

show abstract

The single-nucleotide polymorphism rs743572 of CYP17A1 shows significant association with polycystic ovary syndrome: a meta-analysis

Cited by 7 publications

References 50 publications

The CYP17A1 single-nucleotide polymorphism rs743572 in Iraqi polycystic ovary syndrome patients

The CYP17A1 single-nucleotide polymorphism rs743572 in Iraqi polycystic ovary syndrome patients

Abigene, a Prospective, Multicentric Study of Abiraterone Acetate Pharmacogenetics in Metastatic Castration-Resistant Prostate Cancer

Dibutyl Phthalate Adsorbed on Multiwalled Carbon Nanotubes Causes Fetal Developmental Toxicity in Balb/C Mice

Contact Info

Product

Resources

About