The Sir David Cuthbertson Medal Lecture 1992

Park, Kenneth G. M.

doi:10.1079/pns19930080

Cited by 14 publications

(2 citation statements)

References 36 publications

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“…However, it should be noted that L-arginine can exert some side effects when it is supplemented in high, supraphysiological doses [33,34] and in longterm time period [35,36]. Higher oral doses of Larginine-HCl (>9 g/day) are occasionally associated with nausea, gastrointestinal discomfort, and diarrhea for some subjects [33,34].…”

Section: L-arginine In Dietary Sources: Nutraceutical Aspectsmentioning

confidence: 99%

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L-Arginine in Nutrition: Multiple Beneficial Effects in the Etiopathology of Diabetes

Korac¹

2013

J. Nutr. Ther.

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L-arginine is a nutritionally important amino acid that controls a wide spectrum of cellular functions and physiological processes, acting by itself or through its various metabolites. There are several factors that determine overall L-arginine homeostasis: dietary supplementation, endogenous de novo synthesis, whole-body protein turnover and its extensive metabolism. The destiny of L-arginine is determined by the complex network of enzymes and pathways differentially expressed according to health and disease status. Diabetes is characterized by reduced concentrations of L-arginine in plasma and many tissues, and failure of its metabolic effects. Emerging data suggest that oral supplementation of L-arginine exerts multiple beneficial effects on the complex etiological and pathophysiological basis of diabetes including: i)-cell function and mass and ii) obesity and peripheral insulin resistance. This review emphasizes important aspects of L-arginine action which classifies this amino acid as a promising therapeutic approach in the treatment of diabetes.

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Section: L-arginine In Dietary Sources: Nutraceutical Aspectsmentioning

confidence: 99%

“…In addition, there are few pathophysiological states where L-arginine might be applied with caution including myocardial infarction [41], asthma [42,43], viral infections (i.e. cold sores, genital herpes) [44], cancer [35,45,46], renal failure and liver disease [36,37,47].…”

Section: L-arginine In Dietary Sources: Nutraceutical Aspectsmentioning

confidence: 99%

L-Arginine in Nutrition: Multiple Beneficial Effects in the Etiopathology of Diabetes

Korac¹

2013

J. Nutr. Ther.

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Arginine Silicate Inositol Complex Accelerates Cutaneous Wound Healing

Durmuş

Tuzcu

Özdemir

et al. 2016

Biol Trace Elem Res

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Arginine silicate inositol (ASI) complex is a composition of arginine, silicon, and inositol that has been shown to have beneficial effects on vascular health. This study reports the effects of an ASI ointment on wound healing in rats. A full-thickness excision wound was created by using a disposable 5 mm diameter skin punch biopsy tool. In this placebo-controlled study, the treatment group's wound areas were covered by 4 or 10 % ASI ointments twice a day for 5, 10, or 15 days. The rats were sacrificed either 5, 10, or 15 days after the wounds were created, and biopsy samples were taken for biochemical and histopathological analysis. Granulation tissue appeared significantly faster in the ASI-treated groups than in the control groups (P < 0.05). The mean unhealed wound area was significantly smaller, and the mean percentage of total wound healing was significantly higher in ASI-treated wounds than in the control wounds. Hydroxyproline, collagen, and matrix metalloproteinases were measured in the granulated tissue and found to be affected. Inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS), collagen, matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and various cytokines (TNF-α and IL-1β) measured in this study showed a significant fall in expression level in ASI-treated wounds. The results suggest that topical application of ASI ointment (especially 4 % concentration) has beneficial effects on the healing response of an excisional wound.

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