The sixth sensor: A <i>Candida albicans</i> biofilm master regulator that responds to inter-kingdom interactions

Jakubovics, Nicholas S.

doi:10.1080/21505594.2017.1353864

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…Interestingly, this interaction was also not dependent on the presence of Als1 and Als3. For all these studies, significant questions remain regarding the upstream signals and signaling pathways leading to the regulation of the various genes and mechanisms (Jakubovics, 2017).…”

Section: Regulation Of the Complex Interactionmentioning

confidence: 99%

Recent Advances and Opportunities in the Study of Candida albicans Polymicrobial Biofilms

Pohl

2022

Front. Cell. Infect. Microbiol.

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It is well known that the opportunistic pathogenic yeast, Candida albicans, can form polymicrobial biofilms with a variety of bacteria, both in vitro and in vivo, and that these polymicrobial biofilms can impact the course and management of disease. Although specific interactions are often described as either synergistic or antagonistic, this may be an oversimplification. Polymicrobial biofilms are complex two-way interacting communities, regulated by inter-domain (inter-kingdom) signaling and various molecular mechanisms. This review article will highlight advances over the last six years (2016-2021) regarding the unique biology of polymicrobial biofilms formed by C. albicans and bacteria, including regulation of their formation. In addition, some of the consequences of these interactions, such as the influence of co-existence on antimicrobial susceptibility and virulence, will be discussed. Since the aim of this knowledge is to inform possible alternative treatment options, recent studies on the discovery of novel anti-biofilm compounds will also be included. Throughout, an attempt will be made to identify ongoing challenges in this area.

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Section: Regulation Of the Complex Interactionmentioning

confidence: 99%

Recent Advances and Opportunities in the Study of Candida albicans Polymicrobial Biofilms

Pohl

2022

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

The sixth sensor: A Candida albicans biofilm master regulator that responds to inter-kingdom interactions

Cited by 1 publication

References 16 publications

Recent Advances and Opportunities in the Study of Candida albicans Polymicrobial Biofilms

Recent Advances and Opportunities in the Study of Candida albicans Polymicrobial Biofilms

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