The size of human coronary arteries depending on the physiological and pathological growth of the heart the age, the size of the supplying areas and the degree of coronary sclerosis

Hort, W; Lichti, H; Kalbfleisch, H; Köhler, Friedrich; Frenzel, H; Milzner-Schwarz, U

doi:10.1007/bf00430892

Cited by 47 publications

(14 citation statements)

References 23 publications

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“…These results were in contrast to previous studies attributing enlargement of atherosclerotic coronary arteries primarily to coincidental vessel dilatation with age. 4 The natural history of carotid atherosclerosis has been investigated in several prospective ultrasound studies.5-9 Contrary to the general opinion that atherosclerosis represents a progressive or at best unchanging disease for years, plaque regression occurred in 7% of the nonstenotic lesions in our study of the development of small carotid atheroma. In this study, distinct echomorphological features and hemodynamic patterns were associated with different plaque development.6'9 However, to the best of our knowledge, no data exist on the effect of plaque progression on the vascular geometry of carotid arteries.…”

Section: Compensatory Carotid Artery Dilatation In Early Atherosclerosismentioning

confidence: 56%

Compensatory carotid artery dilatation in early atherosclerosis.

1994

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Background From pathological studies of coronary arteries, it has been recognized that progressive plaque development may be compensated for by an increase of the arterial diameter. However, the dynamics of this process have not been investigated, and it is not known whether compensatory dilatation is a general pathomechanism in human arteries.Methods and Results Using a high-resolution duplex scanner and subsequent three-dimensional plaque reconstruction, we prospectively studied the effect of carotid plaque development on the vascular geometry in 32 patients at 6-to 12-month intervals. Plaque progression in 41% (n=26) of studies was

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Section: Compensatory Carotid Artery Dilatation In Early Atherosclerosismentioning

confidence: 56%

Compensatory carotid artery dilatation in early atherosclerosis.

1994

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“…However, thus far few studies have focused on the relationship among common carotid artery (CCA) luminal enlargement, structural or morphological changes of the artery, and cardiovascular risk factors with the aid of B-mode ultrasonography, 26 -29 although it has been shown that arteries enlarge with increasing age, blood flow, and heart size 30 and that the inner diameter of the aorta increases in the presence of hypertension. 31 In particular, there have been no studies focusing on the relationships between CCA luminal enlargement and cardiovascular risk factors, such as body mass index (BMI), smoking, alcohol consumption, elevated blood lipids, fasting blood glucose (FBG), and high blood pressure, in a large general population with a wide age range.…”

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confidence: 99%

Potential of Carotid Enlargement as a Useful Indicator Affected by High Blood Pressure in a Large General Population of a Japanese City

Mannami

Baba

Ogata

2000

Stroke

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Background and Purpose-Few studies have examined whether there is a relationship between carotid arterial diameter and cardiovascular risk factors in a large general population. The aim of this study was to investigate cross-sectionally whether, in a randomly selected general large population of a Japanese city, there is a relationship between common carotid artery (CCA) diameter and conventional cardiovascular risk factors. Methods-The subjects of the present study were randomly selected from the residents of the city of Suita, located in the second largest urban area of Japan, and consisted of 2284 men and 2568 women aged 30 to 89 years. The outer and inner CCA diameters and intima-media thickness (IMT) of CCA were detected and measured by a single physician with high-resolution ultrasonography. We assessed cross-sectionally by age/sex group the relationships between IMT or CCA diameters and cardiovascular risk factors, especially blood pressure levels divided into 3 groups: the normal group of subjects had a diastolic blood pressure (DBP) Ͻ85 mm Hg and systolic blood pressure (SBP) Ͻ130 mm Hg and were not taking antihypertensive medication; the high group of subjects had DBP Ն90 mm Hg and/or SBP Ն140 mm Hg and/or were taking antihypertensive medication; and the moderate group consisted of all other subjects. Results-The outer and inner CCA diameters for the high group were significantly (PϽ0.05) enlarged in comparison with those for the moderate and normal groups in all age/sex groups of both sexes after adjustment for body mass index, pack-years of smoking, alcohol consumption, and total serum cholesterol. Multiple regression analysis showed that age, body mass index, SBP, pack-years of smoking, alcohol consumption, and IMT were positively and significantly (PϽ0.005) related to both outer and inner CCA diameters in both sexes except for between alcohol consumption and outer CCA diameter in women and showed that only serum total cholesterol level was negatively and significantly (PϽ0.01) related to inner CCA diameter in both sexes. Conclusions-Our present study showed that the outer and inner CCA diameters correlated with conventional cardiovascular risk factors, including high blood pressure and IMT. These findings suggest that the outer and inner CCA diameters may be a useful indicator of carotid atherosclerosis, particularly in relation to high blood pressure. (Stroke. 2000;31:2958-2965.)

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“…They were filled with contrast medium at physiological pressure. Thus the postmortem diameters of coronary arteries correspond well with the intravital ones after application of nitroglycerin [3]. However, tissues shrink when embedded in paraffin.…”

Section: Limitationsmentioning

confidence: 78%

“…They were obtained from 112 coronary artery segments from 65 human hearts on which postmortem coronary angiography had been performed between 1972 and 1976 with a barium sulphate Micropaque and gelatin mixture at a pressure of 100 mmHg [3]. The coronary artery segments were fixed in 4% formalin and embedded in paraffin.…”

Section: Methodsmentioning

confidence: 99%

Inner layer infarction of the coronary artery wall due to coronary thrombosis

Hort

2002

Virchows Archiv

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Cross sections of 112 coronary artery segments from 65 human hearts with coronary thromboses were investigated after postmortem coronary angiography. In almost all cases the inner layers of coronary artery walls adjacent to the obstructing thrombi or to parietal thrombi were infarcted. These infarctions followed nearly the same course as classical infarctions. From 13 hearts with segments occluded by thrombi but without atherosclerotic lesions, 19 specimens were found suitable for quantitative investigations. The 2 segments with the thinnest intima were lacking in inner layer infarctions. The other 17 specimens contained areas of inner layer necrosis of increasing diameter, depending on the thickness of the wall. In each case the media was completely preserved. The mean thickness of the noninfarcted wall tissue was 190+/-28 micro m. This noninfarcted wall tissue was supplied by vasa vasorum in the adventitia located at an average distance of approximately 40 micro m from the media. The knowledge of the supplying areas of the vasa vasorum could help us understand the pathogenesis of necroses in atherosclerotic plaques.

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The size of human coronary arteries depending on the physiological and pathological growth of the heart the age, the size of the supplying areas and the degree of coronary sclerosis

Cited by 47 publications

References 23 publications

Compensatory carotid artery dilatation in early atherosclerosis.

Compensatory carotid artery dilatation in early atherosclerosis.

Potential of Carotid Enlargement as a Useful Indicator Affected by High Blood Pressure in a Large General Population of a Japanese City

Inner layer infarction of the coronary artery wall due to coronary thrombosis

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