The Sjögren Syndrome and Tear Function Profile

Bijsterveld, O. P. Van

doi:10.1007/978-1-4615-5359-5_134

Cited by 3 publications

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“…The tear film alterations responsible for the development of dry eye are probably complex, involving not only tear quantity but also tear quality. A severely reduced production of tear fluid is fundamental, since most patients have extremely low results when examined by the Schirmer-1 test (Prause et al 1982;van Bijsterveld & Mackor 1989;Bjerrum 1996). A disturbance of the quality of the mucus layer composition seems, however, also to be involved in the development of dry eye in 1aeSS, since many patients have a severely reduced tear film stability as shown by the tear film break-up time test (Norn 1991;Bjerrum 1996).…”

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confidence: 99%

Tear fluid analysis in patients with primary Sjögren's syndrome using lectin probes, A comparative study of patients with primary Sjögren's syndrome, patients with other immune inflammatory connective tissue diseases and controls

Bjerrum

1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To study and compare the glycoprotein composition of tear fluid from patients with primary Sjögren's syndrome, patients with other connective tissue diseases and control individuals. Methods: SDS polyacrylamide gel electrophoresis followed by Coomassie staining or Western blotting and overlaying with ten different lectins. Results: The frequency of many glycoprotein bands discovered was significantly decreased in primary Sjögren's syndrome compared with controls and patients with other connective tissue diseases. The reduction was most pronounced in the 14-68 kDa molecular weight range. Conclusions: A decrease in the production rate and/or a change in the glycosylation pattern of the tear glycoproteins was found in patients with primary Sjög-ren's syndrome. The changes discovered, however, were not specific enough to be useful as a diagnostic test.

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confidence: 99%