The Skeletal Muscle of Sheep Affected with Scrapie

Hulland, T. J.

doi:10.1016/s0368-1742(58)80027-2

Cited by 15 publications

(2 citation statements)

References 14 publications

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“…The fact that muscles differ in their potential for muscle fiber size change in emaciation, including that seen in scrapie [21,22], was known earlier and, in fact, was the basis of selection of the four muscles sampled routinely. It was surprising to discover that of the four muscles sampled, only the longissimus muscle had a readily available potential for early fiber enlargement as emaciation began.…”

Section: Discussionmentioning

confidence: 99%

Histochemical and Morphometric Evaluation of Skeletal Muscle of Cachectic Sheep

Hulland

1981

Vet Pathol

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Abstract. Skeletal muscle of sheep was examined histochemically in an attempt to define muscle fiber populations capable of distinctive biological behavior. ATPase at alkaline and acid pH, NADH-TR, and succinic dehydrogenase showed at least 12 fiber types, but only three often enough to be considered biologically important muscle fiber populations. The proportions of the three major types altered during early life, but not perceptibly during adult life. Proportions of Type I and Type I1 fibers were different, sometimes significantly, from breed to breed.Histochemical techniques and morphometric analyses of fiber cross-sectional area were used to study muscle fiber changes in moderate to marked cachectic atrophy. Progressive reduction of gross muscle volume was attended by complex interrelationships between the two major muscle fiber types, including alternate episodes of atrophy and hypertrophy, resulting in marked inequality of mean fiber size between the fiber types. The patterns appeared to be different but characteristic for each muscle. The usual pattern of cachectic atrophy shows atrophy resistance of Type I fibers, but here a Type 11-dominant atrophy also was seen. It is concluded that the large muscle fibers often seen in advanced cachectic atrophy are those Type I fibers that are more labile in both atrophy and hypertrophy than most.

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Section: Discussionmentioning

confidence: 99%

Histochemical and Morphometric Evaluation of Skeletal Muscle of Cachectic Sheep

Hulland

1981

Vet Pathol

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“…They concluded that 'there is no sound evidence that scrapie is due to an infection of the central nervous system'. Detailed study of the muscles (Hulland, 1958) has, however, failed to substantiate lesions, and it appears that a muscular dystrophy was present as an incidental disease in the original material, though Beck et al (1964) found a few lesions of the original type they described.…”

Section: B Pathological Changesmentioning

confidence: 97%

Scrapie: a review of its relation to human disease and ageing.

Field¹

1976

Journal of Medical Genetics

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Familial Neurological Disease Associated With Spongiform Encephalopathy

Rosenthal¹,

Keesey²,

Crandall³

et al. 1976

Archives of Neurology

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In a family in whom susceptibility to neurological diseases was transmitted in autosomal dominant fashion, the diseases affecting different family members ranged from subacute and chronic dementias to various motor system abnormalities without dementia. The propositus suffered a typical clinical course of Creutzfeldt-Jakob disease. Neuropathological observations revealed spongiform encephalopathy. A first cousin had a chronic dementia; no spongiform changes were present at autopsy. Both patients had PAS-positive, eosinophilic plaques throughout the brain. Muscle biopsy of the propositus revealed some changes suggestive of "ragged-red" myopathy. The heterogeneity of disease and the inheritance pattern in this family suggests that general susceptibility to neurological disease is a genetic trait.

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The Skeletal Muscle of Sheep Affected with Scrapie

Cited by 15 publications

References 14 publications

Histochemical and Morphometric Evaluation of Skeletal Muscle of Cachectic Sheep

Histochemical and Morphometric Evaluation of Skeletal Muscle of Cachectic Sheep

Scrapie: a review of its relation to human disease and ageing.

Familial Neurological Disease Associated With Spongiform Encephalopathy

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