The skin barrier function gene <i><scp>SPINK</scp>5</i> is associated with challenge‐proven IgE‐mediated food allergy in infants

Ashley, Sarah; Tan, Hern‐Tze Tina; Vuillermin, Peter; Dharmage, Shyamali C.; Tang, Mimi L.K.; Koplin, Jennifer J.; Gurrin, Lyle C.; Lowe, Adrian J.; Lodge, Caroline; Ponsonby, Anne–Louise; Molloy, John; Martin, Pamela E.; Matheson, Melanie C.; Saffery, Richard; Allen, Katrina J.; Ellis, Justine A.; Martino, David

doi:10.1111/all.13143

Cited by 65 publications

(41 citation statements)

References 37 publications

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“…19 In our study, children born in Asia who subsequently migrated to Australia had a lower risk of food allergy and eczema compared with to differences in allergy rates between growing up in Asia and those growing up in Australia. However, in our previous population-based study in Victoria, we found that parental country of birth was highly correlated (more than 93.0%) with genetically determined Asian or Caucasian ancestry.…”

Section: The Association Between Demographic Factors and Anaphylaximentioning

confidence: 60%

“…However, in our previous population-based study in Victoria, we found that parental country of birth was highly correlated (more than 93.0%) with genetically determined Asian or Caucasian ancestry. 19 In our study, children born in Asia who subsequently migrated to Australia had a lower risk of food allergy and eczema compared with to differences in allergy rates between growing up in Asia and those growing up in Australia. 24 While both eczema and food allergy were around twice as common in Australian-born Asian children as in non-Asian children, the prevalence of asthma was not similarly increased, suggesting a different pathogenesis between asthma and other allergic diseases.…”

Section: The Association Between Demographic Factors and Anaphylaximentioning

confidence: 60%

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Asian children living in Australia have a different profile of allergy and anaphylaxis than Australian‐born children: A State‐wide survey

Wang

Allen

Suaini

et al. 2018

Clin Experimental Allergy

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Section: The Association Between Demographic Factors and Anaphylaximentioning

confidence: 60%

Section: The Association Between Demographic Factors and Anaphylaximentioning

confidence: 60%

Asian children living in Australia have a different profile of allergy and anaphylaxis than Australian‐born children: A State‐wide survey

Wang

Allen

Suaini

et al. 2018

Clin Experimental Allergy

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“…Included studies were of varying sample sizes with the smallest study having 30 food allergy Caucasian cases and 35 nonallergic Caucasian controls, while the largest study was a GWAS with 2197 European subjects (671 with food allergy, 144 nonallergic nonsensitized controls and 1382 European controls of uncertain phenotype) . The majority (n = 11) of included studies were conducted in only “Caucasian,” “European” or “White” populations, whereas 11 studies were carried out in predominantly Caucasian populations alongside other ethnicities (“Asians,” “Mixed” and “African American”) . Four others were carried out in Japanese populations, one was carried out in a Taiwanese population, and there were five studies where ethnicity was not mentioned …”

Section: Resultsmentioning

confidence: 99%

Genetic determinants of paediatric food allergy: A systematic review

Suaini

Wang

Soriano

et al. 2019

Allergy

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Background The genetic determinants of food allergy have not been systematically reviewed. We therefore systematically reviewed the literature on the genetic basis of food allergy, identifying areas for further investigation. Methods We searched three electronic databases (MEDLINE, EMBASE and PubMed) on 9 January 2018. Two authors screened retrieved articles for review according to inclusion criteria and extracted relevant information on study characteristics and measures of association. Eligible studies included those that reported an unaffected nonatopic control group, had genetic information and were carried out in children. Results Of the 2088 studies retrieved, 32 met our inclusion criteria. Five were genome‐wide association studies, and the remaining were candidate gene studies. Twenty‐two of the studies were carried out in a predominantly Caucasian population with the remaining 10 from Asian‐specific populations or unspecified ethnicity. We found FLG, HLA, IL10, IL13, as well as some evidence for other variants (SPINK5, SERPINB and C11orf30) that are associated with food allergy. Conclusions Little genetic research has been carried out in food allergy, with FLG, HLA and IL13 being the most reproducible genes for an association with food allergy. Despite promising results, existing genetic studies on food allergy are inundated with issues such as inadequate sample size and absence of multiple testing correction. Few included replication analyses or population stratification measures. Studies addressing these limitations along with functional studies are therefore needed to unravel the mechanisms of action of the identified genes.

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“…28 Genetic mutations in the SPINK5 gene, which encodes a serine peptidase inhibitor Kazal-type 5 essential for skin regeneration, were challenge-proven to be associated with IgE-mediated food allergy in children. 29 Preliminary results suggest that the polymorphism variant rs9325071 led to increased skin permeability as measured by transepidermal water loss. There is recent evidence suggesting that genetic variants related to adult lung function are associated with lung function and asthma in 10-year-old children.…”

Section: G Ene Ti C S Of Allerg I C D Is E a S E S And A S Thmamentioning

confidence: 96%

Highlights and recent developments in airway diseases in EAACI journals (2018)

Bousquet

Akdiş

Grattan

et al. 2019

Allergy

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The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Pediatric Allergy and Immunology, and Clinical and Translational Allergy. EAACI's major goals include supporting the promotion of health, in which the prevention of allergy and asthma plays a critical role, and disseminating the knowledge of allergic disease to all stakeholders. In 2018, the remarkable progress in the identification of basic mechanisms of allergic and respiratory diseases as well as the translation of these findings into clinical practice were observed. Last year's highlights include publication of EAACI guidelines for allergen immunotherapy, many EAACI Position Papers covering important aspects for the specialty, better understanding of molecular and cellular mechanisms, identification of biomarkers for disease prediction and progress monitoring, novel prevention and intervention studies, elucidation of mechanisms of multimorbidities, introduction of new drugs to the clinics, recently completed phase three clinical studies, and publication of a large number of allergen immunotherapy studies and meta‐analyses.

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The skin barrier function gene SPINK5 is associated with challenge‐proven IgE‐mediated food allergy in infants

Abstract: We report, for the first time, association between SPINK5 variant rs9325071 and challenge-proven IgE-mediated food allergy.

Cited by 65 publications

References 37 publications

Asian children living in Australia have a different profile of allergy and anaphylaxis than Australian‐born children: A State‐wide survey

Asian children living in Australia have a different profile of allergy and anaphylaxis than Australian‐born children: A State‐wide survey

Genetic determinants of paediatric food allergy: A systematic review

Highlights and recent developments in airway diseases in EAACI journals (2018)

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