The skin function: a factor of anti-metabolic syndrome

Zhou, Shi-Sheng; Li, Da; Zhou, Yiming; Cao, Ji-Min

doi:10.1186/1758-5996-4-15

Cited by 49 publications

(54 citation statements)

References 112 publications

(177 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, it should be considered that a disorder in the elimination of reactive oxygen species (ROS) can result in an increased level of circulating lipids and cholesterol in the blood which increases the risk of dyslipidemia and MS (29,30). Based on the results of this research, an increased level of ROS and lipid peroxidation in LP was observed, which enhanced the inflammatory response by immunological mechanism and increased the serum level of nitric oxide, malondialdehyde, and superoxide dismutase (31)(32)(33)(34).…”

Section: Discussionmentioning

confidence: 79%

The Association of Cutaneous Lichen Planus and Metabolic Syndrome: A Case-Control Study

et al. 2016

View full text Add to dashboard Cite

Background: Previous research declares that metabolic syndrome (MS) is a cluster of risk factors that contribute to a significant level of incidence of cardiovascular diseases and diabetes mellitus. Lichen Planus (LP) is a potential factor to affect dyslipidemia and other components of MS. Objectives: The aim of this research was to assess the association of MS, dyslipidemia, weight, hypertension, and diabetes mellitus with cutaneous LP. Methods: To reach the goal of this research, a case-control study was designed. The study sample included 140 participants dividing into two groups of 70. The first group was selected from cutaneous LP patients while the second group was selected randomly. The groups were matched in terms of age and gender. Results:The results of this research demonstrated that MS was present in 41 (58.6%) LP patients vs. 12 (17.1%) controls. (OR: 6.83; P value < 0.001). All metabolic syndrome criteria were significantly common among LP patients except for decreased high density of lipoprotein level. Dyslipidemia was observed in 57 (81.42%) patients vs. 25 (31.7%) controls (OR: 7.8; P value < 0.001). No statistically significant association was found between gender, the concomitant involvement of oral mucosa, hair, or nail and MS. Conclusions: Based on the results of this research, it can be concluded that cutaneous LP is in association with a significant level of risk for metabolic syndrome, dyslipidemia, diabetes mellitus, and hypertension. It can also be concluded that the investigation of cardiovascular risk factors in these patients and focusing on the modification of their lifestyle and comorbidities are the other essential issues.

show abstract

Section: Discussionmentioning

confidence: 79%

The Association of Cutaneous Lichen Planus and Metabolic Syndrome: A Case-Control Study

et al. 2016

View full text Add to dashboard Cite

show abstract

“…It has been proposed that any derangement in the elimination of ROS through sebum will increase levels of circulating lipids and cholesterol, thus increasing the risk of dyslipidemia and Metabolic syndrome. 9,11 The proposed immunological defect in endocrine dysfunction causing diabetes mellitus may also contribute to development of lichen planus.…”

Section: Introductionmentioning

confidence: 99%

A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

2017

View full text Add to dashboard Cite

Background: Lichen planus is an autoimmune, inflammatory papulosquamous disease affecting skin and mucous membrane with a possible association with the parameters of metabolic syndrome.Methods: We carried out a hospital based case control study among patients attending DVL OPD during a period of 1.5 years (January 2015 - May 2016). Study population included 40 cases of LP and 80 age and sex matched controls. Relevant history, clinical examination and blood investigations were done. Diagnosis of MS was made based on IDF criteria.Results: There was no significant association between metabolic syndrome and lichen planus (p=0.292). Although there was higher prevalence of hypertension (47.5% vs. 27.5%, p=0.029), triglyceride level (25% vs. 10%, p=0.030) and low HDLC levels (65% vs. 45%, p=0.039). We could not establish significant association between FBS and waist circumference with LP.Conclusions: Though metabolic syndrome was not significantly associated with LP, its components such as hypertension, triglycerides and low HDLC levels were significantly associated with LP as per the study. Therefore patients with LP need to be screened to rule out each of these parameters to avoid later complications.

show abstract

“…15 Vitiligonun patogenezinde yer alan serbest oksijen radikallerinin metabolik olaylar ile de ilişkili olabileceği dü-şünülmüştür. 16 Obez insanların adipoz dokusunda melanogenezisin artması bu durumu desteklemektedir. 17 İnflamatuar süreçte doğal immün sistem tarafından salınan bazı endojen antiinflamatuar mediyatörlerin proinflamatuar ve antiinflamatuar faktörler arasındaki dengeyi sağlayarak inflamasyonu kontrol edebildiği bildirilmektedir.…”

Section: Discussionunclassified

Evaluation of Serum Ghrelin Levels in Patients with Vitiligo

Demir¹,

Uçak²,

Çiçek³

et al. 2014

Turkiye Klinikleri J Dermatol

View full text Add to dashboard Cite

Ö ÖZ ZE ET T A Am ma aç ç: : Vitiligonun insülin direnci, lipid anormallikleri ve metabolik sendrom gibi metabolik bozukluklarla ilişkili olduğuna dair çeşitli çalışmalar vardır. Plazma grelin seviyeleri obez bireylerde düşük bulunmuş ve hiperinsülinemi ve insülin direnci gibi metabolik sendromun önemli bulgularından biri olarak kabul edilmiştir. Bu çalışmanın amacı, vitiligolu hastalarda serum grelin seviyelerini incelemektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya 30 vitiligolu hasta ve 30 kontrol birey alındı. Açlık kan şekeri, serum lipidleri, insulin, C-peptid ve tiroid fonksiyon testlerine bakıldı. İn-sülin direncinin ölçülmesi için ["The homeostasis model assessment of insulin resistance (HOMA-IR")] indeksi kullanıldı. Grelin seviyeleri "enzyme-linked immunosorbent assay (ELISA)" yöntemi ile üretici firmanın protokolüne uygun olarak belirlendi. B Bu ul lg gu ul la ar r: : Ortalama serum grelin seviyesi vitiligolu hastalarda (45,27±16,12 pg/mL), kontrol grubuna göre (35,89±19,37 (pg/mL) göre, istatistiksel olarak anlamlı yüksek tespit edildi (p=0,04). Serum grelin seviyesi insülin direnci olan (31,65±16,69 pg/mL)]vitiligolu hastalarda insülin direnci olmayanlara (43,55±17,99 pg/mL) göre istatistiksel olarak anlamlı düşük saptandı (p=0,02). S So on nu uç ç: : Vitiligolu hastalarda serum grelin seviyeleri kontrollere göre anlamlı yüksek tespit edildi. Bu durum serum glukoz seviyesi ve beden kitle indeksi ile korele edilemedi. Serum grelin seviyesindeki yükselmenin vitiligolu hastalardaki oksidatif stresle ilişkili olabileceği düşünüldü.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Grelin; vitiligo; insülin direnci A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : There are several publications about vitiligo being related to metabolic disturbances such as insulin resistance, lipid abnormalities, and metabolic syndrome. Plasma ghrelin levels were found to be low in obese patients and it is accepted to be one of important findings of metabolic syndrome such as hyperinsulinemia and insulin resistance. The current study aimed to investigate change in serum ghrelin levels in patients with vitiligo. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 30 patients presenting with vitiligo and 30 control subjects participated in this study. Fasting blood glucose, serum lipids, insulin, C-peptide and thyroid function tests were measured. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate insulin resistance. Ghrelin levels were determined by enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's protocol. R Re es su ul lt ts s: : The mean serum ghrelin levels in the vitiligo patient group was 45.27±16.12 pg/mL and was statistically significantly higher in the control group 35.89±19.37 pg/mL, (p=0.04). The mean serum ghrelin level in the patients with insulin resistance 31.65±16.69 pg/mL was compared to the patient without insulin resistance 43.55±17.99 pg/mL and found statistically significant lower (p=0...

show abstract

The skin function: a factor of anti-metabolic syndrome

Cited by 49 publications

References 112 publications

The Association of Cutaneous Lichen Planus and Metabolic Syndrome: A Case-Control Study

The Association of Cutaneous Lichen Planus and Metabolic Syndrome: A Case-Control Study

A prospective case control study on metabolic syndrome in lichen planus in a tertiary care centre

Evaluation of Serum Ghrelin Levels in Patients with Vitiligo

Contact Info

Product

Resources

About