The skin microbiome drives immune maturation and exacerbation of both skin and airway inflammation

Ubags, Niki; Trompette, Aurélien; Nibbering, Britt; Pernot, Julie; Pattaroni, Céline; Rapin, Alexis; Nicod, Laurent; Marsland, Benjamin J.

doi:10.1183/23120541.lungscienceconference-2019.pp228

Cited by 1 publication

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“…4 In addition, it has been mentioned that these dermal microbiotas could have some influence on the activation and reaction of the immune system. 5 UV radiation biological interference in humans alters since the wavelength ranges with different subdivisions as A, B, and C. UV light could be beneficial and harmful for humans. 6,7 There are pieces of evidence about the role of UV radiation in skin damage.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Microbiome Role in Skin Protection Against UV Irradiation Via Network Analysis

et al. 2020

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Introduction: Diverse microbiotas which have some contributions to gene expression reside in human skin. To identify the protective role of the skin microbiome against UV exposure, proteinprotein interaction (PPI) network analysis is used to assessment gene expression alteration. Methods: A microarray dataset, GEO accession number GSE117359, was considered in this respect. Differential expressed genes (DEGs) in the germ-free (GF) and specific pathogen-free (SPF) groups are analyzed by GEO2R. The top significant DEGs were assigned for network analysis via Cytoscape 3.7.2 and its applications. Results: A total of 28 genes were identified as significant DEGs and the centrality analysis of the network indicated that only one of the seven hub-bottlenecks was from queried genes. The gene ontology analysis of Il6, Cxcl2, Cxcl1, TNF, Il10, Cxcl10, and Mmp9 showed that the crucial genes were highly enriched in the immune system. Conclusion: The skin microbiome plays a significant role in the protection of skin against UV irradiation and the role of TNF and IL6 is prominent in this regard.

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