The skin microbiota as a link between rosacea and its systemic comorbidities

Thompson, Katherine G.; Rainer, Barbara M.; Kang, Sewon; Chien, Anna L.

doi:10.1111/ijd.14802

Cited by 10 publications

(14 citation statements)

References 7 publications

(14 reference statements)

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“…Chronic inflammation in rosacea patients may be systemic, and inflammation may link rosacea and cardiometabolic disease [79]. Skin microbiota may also act as a link between rosacea and its comorbidities [80]. Recognizing and screening systemic disorders in rosacea patients may be beneficial in the early diagnosis and treatment of these diseases [79,81].…”

Section: Systemic Comorbiditiesmentioning

confidence: 99%

Rosacea Treatment: Review and Update

Zhang

Tang

Wang

et al. 2020

Dermatol Ther (Heidelb)

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Rosacea is a chronic and inflammatory skin disease characterized by flushing, nontransient erythema, papules/pustules, telangiectasia, and phymatous changes. Secondary manifestations, such as itching, burning, or stinging, are often observed in patients with rosacea. In 2017, a phenotype-based approach for diagnosis and classification was recommended. With the update of the diagnosis and classification of rosacea, treatment options for patients with rosacea have attracted the attention of dermatologists. Here, we summarize the latest advances in rosacea treatment, including skin care and cosmetic treatments, topical therapies, oral therapies, laser- and light-based therapies, injection therapies, treatments for specific types of rosacea, treatments for systemic comorbidities, and combination therapies. The impact of the phenotype-based approach on rosacea treatment and future directions are also discussed.

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Section: Systemic Comorbiditiesmentioning

confidence: 99%

Rosacea Treatment: Review and Update

Zhang

Tang

Wang

et al. 2020

Dermatol Ther (Heidelb)

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“…10 These external and endogenous factors can lead to a dysregulated innate and adaptive immune response prone to excessive inflammation and vasodilation combined with neurogenic dysregulation. 23 Collectively, all of the mentioned mediators and processes orchestrate vascular and inflammatory effects that are characteristic of rosacea. Figure 1 schematizes, for better visualization, the main aspects involved in the pathophysiology of rosacea.…”

Section: Rosaceamentioning

confidence: 99%

“…10 Moreover, the activation of T helper (Th) 1, Th17, and B cells promotes inflammation due to the production of interferon-c, IL-17, and immunoglobulins. 23,36 Recent developments in the field of rosacea have suggested that patients overexpress transient receptor potential (TRP) vanilloid type (TRPV) 1, TRPV4, and TRP ankyrin 1 (TRPA) ion channels commonly found on sensory neurons and keratinocytes. These TRPs are highly stimulated by thermal, chemical, or mechanical factors.…”

Section: Rosaceamentioning

confidence: 99%

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Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems

et al. 2023

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Rosacea is a multifactorial chronic inflammatory dermatosis characterized by flushing, nontransient erythema, papules and pustules, telangiectasia, and phymatous alterations accompanied by itching, burning, or stinging, the pathophysiology of which is not yet fully understood. Conventional topical treatments usually show limited efficacy due to the physical barrier property of the skin that hinders skin penetration of the active ingredients, thereby hampering proper drug skin delivery and the respective therapeutic or cosmetic effects. New advances regarding the physiopathological understanding of the disease and the underlying mechanisms suggest the potential of new active ingredients as promising therapeutic and cosmetic approaches to this dermatosis. Additionally, the development of new drug delivery systems for skin delivery, particularly the potential of nanoparticles for the topical treatment and care of rosacea, has been described. Emphasis has been placed on their reduced nanometric size, which contributes to a significant improvement in the attainment of targeted skin drug delivery. In addition to the exposition of the known pathophysiology, epidemiology, diagnosis, and preventive measures, this Review covers the topical approaches used in the control of rosacea, including skin care, cosmetics, and topical therapies, as well as the future perspectives on these strategies.

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“…Patients with rosacea may have systemic comorbidities, including diseases of the gastrointestinal tract (e.g., gastroesophageal reflux disease, gastritis, Crohn's disease, ulcerative colitis, celiac disease, and small intestinal bacterial overgrowth [SIBO] syndrome), suggesting a link between rosacea and the gut [31][32][33]. Furthermore, the gut microbiota has been shown to influence skin homeostasis: either directly in case of intestinal barrier disruption, or indirectly through the modulation of systemic immunity or by generating shortchain fatty acids [7].…”

Section: Does the Gut Microbiota Play A Role In Rosacea?mentioning

confidence: 99%

Microbiota in Rosacea

Kim

2020

Am J Clin Dermatol

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Rosacea is a complex facial skin condition associated with abnormal inflammation and vascular dysfunction. Next to the known trigger factors, the role of microbiota in the development and aggravation of rosacea continues to raise interest. Demodex folliculorum mites, Helicobacter pylori, Staphylococcus epidermidis, Chlamydia pneumoniae, and the Demodexassociated bacterium, Bacillus oleronius are microbes that have been linked with rosacea. However, the results of studies which assessed their involvement in the disease have been inconsistent and inconclusive. Microbiological research in many different disciplines exploded in recent years as methods to analyze complex microbial communities at the taxonomic and phylogenetic levels became available. Here, we provide an update on the microorganisms implicated in rosacea and review the potential pathogenic role of microbes in the development of rosacea. Key Points Microbes have long been suspected to play a role in rosacea. Better understanding of the microbiota and its role in rosacea pathophysiology may help determine the impact of microbial dysbiosis and host reactivity in rosacea populations. Deeper knowledge of microbe-host interactions in rosacea will allow targeted patient care and aid the development of innovative therapies.

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The skin microbiota as a link between rosacea and its systemic comorbidities

Cited by 10 publications

References 7 publications

Rosacea Treatment: Review and Update

Rosacea Treatment: Review and Update

Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems

Microbiota in Rosacea

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