The small intestine and colon: scintigraphic quantitation of motility in health and disease

Kamm, Michael A.

doi:10.1007/bf00168168

Cited by 20 publications

(8 citation statements)

References 24 publications

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“…As the radiographic appearance of pseudo-obstruction may mimic mechanical obstruction, ultrasonography may help to confirm whether such an obstruction exists. Recently, scintigraphy has been suggested as a means to evaluate intestinal motility disorders (Kamm 1992).…”

Section: Discussionmentioning

confidence: 99%

Chronic idiopathic intestinal pseudo‐obstruction in an English bulldog

Dvir

Leisewitz

Lugt

2001

J of Small Animal Practice

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A case of chronic idiopathic intestinal pseudo-obstruction in an English bulldog is described. The dog was presented with chronic weight loss and vomiting. An intestinal obstruction was suspected based on clinical and radiological findings. A diagnosis of chronic idiopathic intestinal pseudo-obstruction was made on the basis of full thickness intestinal biopsies. The dog was refractory to any antiemetic therapy. Necropsy revealed marked atrophy and fibrosis of the tunica muscularis, together with a mononuclear cell infiltrate extending from the duodenum to the colon. This case was presented with clinical findings consistent with visceral myopathy in humans--namely, atony and dilatation of the whole gut--but the histological findings resembled sclerosis limited to the gastrointestinal tract.

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Section: Discussionmentioning

confidence: 99%

Chronic idiopathic intestinal pseudo‐obstruction in an English bulldog

Dvir

Leisewitz

Lugt

2001

J of Small Animal Practice

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“…[1][2][3][4][5] Therefore, a functional disorder is suggested. 6,7 Intestinal pseudo-obstruction may be primary (idiopathic) or secondary to endocrine disorders, connective tissue diseases, neurologic disorders, drugs, infections, and malignancies.…”

mentioning

confidence: 98%

“…9 The diagnosis of intestinal pseudo-obstruction is based on symptoms of intestinal obstruction; typical manometric, scintigrafic, and radiologic findings; pathologic full thickness biopsy; and exclusion of mechanical obstruction. [1][2][3][4][5]7 Depending on the amount of intestine and parts involved, the symptoms may vary. The most common symptoms are abdominal pain, vomiting, distention, constipation, and diarrhea.…”

mentioning

confidence: 99%

Sympathetic Nerve Dysfunction is Common in Patients With Chronic Intestinal Pseudo-obstruction

Mattsson¹,

Roos²,

Sundkvist

et al. 2008

Journal of Clinical Gastroenterology

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“…The orofaecal time was significantly different between three groups: rapid transit, normal, or delayed colonic transit (p<000l), but not between different types of delayed transit. (1)(2)(3)(4)(5)(6)(7)(8) 14-1 25.7 (5.9) elay 6-7 (5 9) 24-6 (8-0) 32-6 ( 8 6) 39-9 (11 9) 148-3 (47 8) practice permitting us to perform a test akin to alay 523 (11) 8-29-9 (3-2) 1417 (588) direct bolus delivery into the terminal ileum . analysed 101l colonic transit studies in a variety of colonic disorders and established several patterns of transit.…”

Section: Arrival Timesmentioning

confidence: 99%

“…A second set of analyses was performed to determine which of the recorded imaging times was the most appropriate to define the five groups of transit patterns clearly so that a simplified method could be based on these images: (1) The percentage of activity in each region of interest was compared between the five groups at 4, 6, 8, 10 hours after the ingestion on the first day, at 27, 31, 34 hours on the second day, and at 51, 55, 58 hours on the third day; (2) the geometric centre for each group was also compared at each time point; (3) activity in each region during the course of second and third day (three images each day) was compared to detect any significant difference between images on the same day.…”

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confidence: 99%

Simplified method for the measurement of segmental colonic transit time.

Notghi

Hutchinson²,

Kumar³

et al. 1994

Gut

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Segmental colonic transit has been measured in 101 patients. Two MBq of ll'Indium absorbed on resin pellets and encapsulated in an enteric coated capsule was given at 700 am. Hourly images during the first day, and three images during each subsequent day were acquired for up to three days. Using all scan and patient data the scans were categorised in one of the five patterns of colonic transit: normal, rapid, right delay, left delay, or generalised delay. The geometric centres and per cent activity at each time point was compared between the five groups of colonic transit patients to find the best time for imaging and so to distinguish the five groups. During the first day, early images did not help in diagnosis of patterns of transit, however, in the later images (six hours onwards after the ingestion of the activity) the rapid transit groups could be identified. Images at 27 and 51 hours were both required to distinguish all five groups of patients from each other. Only in the 'normal' transit patients was there some excretion of the activity during the course of the second day, otherwise there was no difference in the images taken in the course of a day (second or third day). A simplified protocol requires a minimum of three images to distinguish all five patterns of colonic transit. The activity should be ingested in the morning (7 00 am) and the first image taken at the end of the working day (8-10 hours after ingestion), the second image on the morning of the second day, and the third image during the course of the third day. This simple protocol would provide all the clinically relevant information necessary for correct classification of the colonic transit. (Gut 1994; 35: 976-981) There has been an increasing interest in the assessment of normal and abnormal large bowel function using manometric, electrophysiological, volumetric, x ray, and scintigraphic methods, some of which are invasive and most are time and labour intensive. 1-3 Radiology has established itself as the main method of measurement of colonic transit. Elaborate x ray techniques, however, have been abandoned in favour of simplified tests for routine clinical use.4 Scintigraphy is one of the least invasive of these procedures, and yet can supply clinicians with important functional information.5 6 As with many new investigations the early protocols entail extensive monitoring over prolonged time to obtain the fullest possible information.5 7 Krevsky et al has instilled radioactivity directly into the caecum.7 This permits detailed and accurate measurement of the transit through the colon. It may not be entirely physiological, however, because of intubation and it is not practical for routine clinical use. Most other studies5 6 8 have used multiple imaging during the first day followed by several images in the following three to seven days. Some centres have already used a simplified method for clinical practice,9 but there is no study that evaluates and rationalises the use of this simplified method for routine colonic transit s...

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The small intestine and colon: scintigraphic quantitation of motility in health and disease

Cited by 20 publications

References 24 publications

Chronic idiopathic intestinal pseudo‐obstruction in an English bulldog

Chronic idiopathic intestinal pseudo‐obstruction in an English bulldog

Sympathetic Nerve Dysfunction is Common in Patients With Chronic Intestinal Pseudo-obstruction

Simplified method for the measurement of segmental colonic transit time.

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