The small scale functional topology of movement control: Hierarchical organization of local activity anticipates movement generation in the premotor cortex of primates

Bardella, Giampiero; Pani, Pierpaolo; Brunamonti, Emiliano; Giarrocco, Franco; Ferraina, Stefano

doi:10.1016/j.neuroimage.2019.116354

Cited by 13 publications

(69 citation statements)

References 67 publications

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“…the number of modules on which it acts as a driver. In Go trials (left) the topology documented a more centralized (in terms of VD out ) organization compared to the Stop trials (right), confirming previous observations 18 . With the insights provided by the TE analysis, the emerging picture is of a network changing not only in the overall organization but also in the role of the components.…”

Section: Resultssupporting

confidence: 83%

“…The arrow for each connection indicates the direction (in/out) for the information path. In Go trials (top) the topology documented a more centralized (in terms of V D out ) organization (star-like topology) compared to the Stop trials (bottom), confirming previous observations 18 . Indeed, in a recent study on correlation networks during the same task we showed that the presence of a star-like topology in the PMd network is the hallmark of the incoming movement.…”

Section: Local Spiking Activities Can Be Grouped In Classes Providing Different Contribution To the Network Information Dynamicssupporting

confidence: 84%

“…Lastly, our findings clearly show that hierarchical control is not only external but is also implemented locally by a specific neuronal class (the Common_drivers) over the others. Throughout the years, much evidence has been brought to support the idea that the brain is hierarchically organized both globally and locally on a spatial 18,[53][54][55][56][57][58][59][60][61][62][63][64] (for a detailed review see Hilgetag et al, 2020 65 ) and temporal scale [66][67][68][69][70][71] . As far as we know, this is the first work that deeply investigates the local hierarchy of a single cortical area known to have a crucial role in the motor system.…”

Section: A Race With More Than Two Horses Is In Act In Pmd When Movements Are Successfully Suppressedmentioning

confidence: 99%

“…Here, aiming to contribute to the understanding of the role of the dorsal premotor (PMd) cortex in arm motor control [8][9][10] we studied the local spiking activity (SA) derived from a multi-electrode array and implemented a combined information-theory and topological approach to describe how the collective activity of mesoscopically-defined local modules is linked to motor decision-making. Indeed, it has been shown that neurons express more their contribution to complex behavioural functions either when observed as coordinated functional ensembles [11][12][13][14][15][16][17][18][19] or described as common responses to the input they receive (e.g., the visual stimulus orientation columns 20 ). A paradigmatic example is the interaction between fixation and movement neurons in the epochs preceding saccade generation 13,14 .…”

Section: Introductionmentioning

confidence: 99%

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Response inhibition in premotor cortex corresponds to a complex reshuffle of the mesoscopic information network

Bardella

Giarrocco

Andujar

et al. 2021

Preprint

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Despite recent works have investigated functional and effective cortical networks in animal models, the dynamical information transfer among functional modules underneath cognitive control is still largely unknown. Here we addressed the issue by using transfer entropy and graph theory methods on neural activities recorded from a multielectrode (96 recording sites) array in the dorsal premotor cortex of rhesus monkeys. We focused our analysis on the decision time of a stop-signal (countermanding) task. When comparing trials with successful inhibition to those with generated movement we found evidence of heterogeneous interacting modules described by 4 main classes, hierarchically organized. Interestingly, the hierarchical organization resulted different in the two type of trials. Our results suggest that motor decisions are based on the local re-organization of the premotor cortical network

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Section: Resultssupporting

confidence: 83%

Section: Local Spiking Activities Can Be Grouped In Classes Providing Different Contribution To the Network Information Dynamicssupporting

confidence: 84%

Section: A Race With More Than Two Horses Is In Act In Pmd When Movements Are Successfully Suppressedmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Response inhibition in premotor cortex corresponds to a complex reshuffle of the mesoscopic information network

Bardella

Giarrocco

Andujar

et al. 2021

Preprint

Self Cite

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show abstract

“…In nature, a lot of practical complex networks such as intelligent networks, food webs, and neural networks can be boiled down to the interaction between nodes and edges, which has aroused many researchersʼ interests in interdisciplinary sciences and applied sciences [1][2][3]. us, modeling and controlling of complex networks have become burning issues due to their potential demand in broad fields [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Layered Synchronization and Identification of Uncertain Delayed Hierarchical Networks

Chai

Zhang

2021

Mathematical Problems in Engineering

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This paper investigates the layered synchronization and identification of uncertain delayed hierarchical networks, featured by highlights in three aspects: first, the presentation of a multilayered delayed network model, which can be regarded as a 3D stereochemical structure in compliance with the ever-developing trend of hierarchical network modeling structure; second, the design of a multi-identification scheme combined with uncertain delayed hierarchical networks, which matches the unknown and hierarchical properties of the proposed networks; and third, the construction of a layered control method of Lyapunov function, which synthesizes the factors of the unknown, time delay and hierarchy. Based on these points, the laws of layered synchronization between drive hierarchical networks (DHNs) and response hierarchical networks (RHNs) are derived, the dual identification criteria for monitoring topological structures and identifying system parameters, respectively, are provided, and the hierarchical multiformity of the proposed method is validated through abundant numerical simulations in the end.

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Neuronal dynamics of signal selective motor plan cancellation in the macaque dorsal premotor cortex

Giarrocco

Bardella

Giamundo

et al. 2021

Cortex

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Primates adopt various strategies to interact with the environment. Yet, no study has examined the effects of behavioral strategies with regard to how movement inhibition is implemented at the neuronal level. We modified a classical approach to study movement control (stop-task) by adding an extra signal-termed the Ignore signal-which influenced movement inhibition only under a specific strategy. We simultaneously recorded multisite neuronal activity from the dorsal premotor (PMd) cortex of macaque monkeys during a task and applied a statespace approach. As a result, we found that movement generation is characterized by neuronal dynamics that evolve between subspaces. When the movement is halted, this evolution is arrested and inverted. Conversely, when the Ignore signal is presented, inversion of the evolution is observed briefly and only when a specific behavioral strategy is adopted. Moreover, neuronal signatures during the inhibitory process were predictive of how PMd processes inhibitory signals, allowing the classification of the resulting behavioral strategy. Our data corroborate the PMd as a critical node in movement inhibition. .

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The small scale functional topology of movement control: Hierarchical organization of local activity anticipates movement generation in the premotor cortex of primates

Cited by 13 publications

References 67 publications

Response inhibition in premotor cortex corresponds to a complex reshuffle of the mesoscopic information network

Response inhibition in premotor cortex corresponds to a complex reshuffle of the mesoscopic information network

Layered Synchronization and Identification of Uncertain Delayed Hierarchical Networks

Neuronal dynamics of signal selective motor plan cancellation in the macaque dorsal premotor cortex

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