A self-powered and neutrally buoyant sensor particle has been developed for the long-term measurement of spatially distributed process parameters in the chemically harsh environments of large vessels. One intended application is the measurement of flow parameters in stirred fermentation biogas reactors. The prototype sensor particle is a robust and neutrally buoyant capsule, which allows free movement with the flow. It contains measurement devices that log the temperature, absolute pressure (immersion depth) and 3D-acceleration data. A careful calibration including an uncertainty analysis has been performed. Furthermore, autonomous operation of the developed prototype was successfully proven in a flow experiment in a stirred reactor model. It showed that the sensor particle is feasible for future application in fermentation reactors and other industrial processes.