The smoothness index

Rizzoni, Damiano; Paini, Anna; Ciuceis, Carolina De; Agabiti-Rosei, Claudia; Salvetti, Massimo

doi:10.1097/hjh.0000000000002236

Cited by 1 publication

(1 citation statement)

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“…SI is calculated as the ratio between the average of the 24 hourly BP changes induced by a given medication and the standard deviation of hourly reductions and it represents the useful measures of the homogeneity of the antihypertensive effect over 24 hours; in fact the SI provides a superior measure of the homogeneity of BP. 35 All combination therapies have higher SI than monotherapy. Amlodipine is consistent in BP reduction throughout 24 hours because of a high trough to peak concentration (T: p = 0.85) and a high SI.…”

Section: Amlodipine: Blocks All Types Of Calcium Channelsmentioning

confidence: 99%

24-Hour Blood Pressure Control with Amlodipine: A Review of the Current Scenario

Nair

Kumar

Unni

et al. 2022

Journal of Cardiac Critical Care TSS

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Introduction Hypertension is the leading cause of cardiovascular diseases and premature death worldwide. Antihypertensive therapy using calcium channel blockers (CCBs) is one of the preferred choices to treat blood pressure (BP) and control blood pressure variability (BPV). In contrast to clinic BP, 24-hour ambulatory BP monitoring (ABPM) has evolved into an accurate and reproducible tool for the assessment and management of hypertension. Amlodipine, a longer acting dihydropyridine CCB is effective for 24 hours BP control and also minimizing BPV. The present article is the comprehensive review highlighting the efficacy of amlodipine in controlling 24-hour BP and minimizing BPV from the review of recent studies. Materials and Methods The literature search was done using PubMed, Google Scholar, and MEDLINE databases. The studies to be included for review, were identified through the keywords: “amlodipine,” “ambulatory BP monitoring (ABPM),”“blood pressure variability (BPV),” “CCBs,” and filtering articles published in English language only. Results Pharmacological evidence suggests that amlodipine has the ability to block all the subtypes of CCBs such as L-, N-, P-, Q-, R-, and T-type. Various clinical studies reported that amlodipine is a powerful, well-tolerated, and safe antihypertensive agent which is widely used either alone or as a key component of combination therapy for control of 24 hours BP. Conclusion Overall, amlodipine is a proven and effective antihypertensive drug and helpful in controlling 24-hour BP, minimizing BP variability and hence reducing the risk of cardiovascular complications.

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Section: Amlodipine: Blocks All Types Of Calcium Channelsmentioning

confidence: 99%