The SNP rs1883832 in CD40 Gene and Risk of Atherosclerosis in Chinese Population: A Meta-Analysis

Abstract

BackgroundThe complications of atherosclerosis such as coronary and cerebrovascular disease, are the most prevalent causes of mortality and morbidity worldwide. A single nucleotide polymorphism (SNP) rs1883832 (-1C/T) in CD40 gene has been recently suggested to contribute to the susceptibility to atherosclerosis in Chinese population; however, previous genetic association studies yielded inconsistent results.MethodsA meta-analysis of eligible studies reporting the association between rs1883832 and atherosclerosis in Chinese population was carried out.ResultsPooling 7 eligible case-control studies involving 2129 patients and 1895 controls demonstrated a significant association between rs1883832 and atherosclerosis under dominant model [odds ratio (OR) = 1.631, 95% confidence interval [CI] [1.176, 2.260] in Chinese population with evident heterogeneity. Meta-regression analysis indicated that the heterogeneity could be completely explained by disease category. In subgroup analysis, rs1883832 conferred ORs of 2.866 (C/C versus T/T, 95%CI [2.203, 3.729]) and 1.680 (C/T versus T/T, 95%CI [1.352, 2.086]) for coronary artery disease (CAD) under co-dominant model without heterogeneity. Similar results were obtained for acute coronary syndrome (ACS) (C/C versus T/T, 3.674, 95%CI [2.638, 5.116]; C/T versus T/T, 1.981, 95%CI [1.483, 2.646]). The other genetic models including dominant, recessive and additive models, yielded consistent results without heterogeneity for CAD and ACS, respectively. However, a protective role was found for C allele in ischemic stroke (IS) under recessive model (0.582, 95%CI [0.393, 0.864]) and additive model (0.785, 95%CI [0.679, 0.909]) with reduced heterogeneity.ConclusionsThis meta-analysis provided evidence of association of rs1883832 C allele with an overall increased risk of atherosclerosis but distinct effect of C allele on CAD (including ACS) and IS in Chinese population, respectively.

Association of six CpG-SNPs in the inflammation-related genes with coronary heart disease

“…CD40 is considered to determine T cell responses to antigen presentation and B cells immunoglobulin isotype switching, which plays a key role in the inflammatory and prothrombotic processes by bonding with CD40 ligand (CD40L) in atherosclerosis [ 37 ]. Previous study provided evidence of association of CD40 rs1883832 with an overall increased risk of CHD in Chinese population [ 38 ]. In the current study, a similar result was drawn that CD40 rs1800686-A allele contributed to CHD risk.…”

The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease

“…Genetic studies have identified correlations between singlenucleotide polymorphism (SNP) in the CD40 gene and atherosclerotic risk, in particular the -1T>C SNP in the Kozak consensus sequence of the CD40 gene (rs1883832) [43][44][45][46][47]. A meta-analysis of 7 studies identified a significant correlation between rs1883832 and atherosclerotic CVD in Chinese populations [45]. Recently, Sultan et al extended these findings to the Caucasian population and also studied the functional consequences of this SNP in endothelial cells [43].…”

Genetic Variants of CD40 Gene Are Associated with Coronary Artery Disease and Blood Lipid Levels

“…Studies showed that polymorphisms in CD40 may influence individuals' susceptibility to the development of cardiovascular events [ 18 , 26 ]. Studies had reported the relationship between rs1883832 at CD40 locus and acute coronary syndrome [ 27 , 28 ]. In this study, we selected two different tag SNPs (rs1535045 and rs4239702) at the CD40 locus to analyze the relationship between the two different tag SNPs and CAD in Chinese Han population.…”