The SNP rs3746444 within mir-499a is associated with breast cancer risk in Iranian population

Kabirizadeh, Shahrzad; Azadeh, Mansoureh; Mirhosseini, Mahboubeh; Ghaedi, Kamran; Tanha, Hamzeh Mesrian

doi:10.1016/j.jocit.2016.08.003

Cited by 14 publications

(15 citation statements)

References 17 publications

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“…As for this research, ANRIL showed a negative association with miR-499a, and PDCD4 was a target of miR-499a. miR-499a polymorphism was associated with the progression of several cancers, such as oral squamous cell carcinoma [39], breast cancer [40] and hepatocellular carcinoma [41]. The genetic polymorphism of miR-499 A>G (rs3746444) is also associated with the risk of ischemic stroke in a Chinese people [42].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Overexpression of lncRNA ANRIL aggravated hydrogen peroxide-disposed injury in PC-12 cells via inhibiting miR-499a/PDCD4 axis-mediated PI3K/Akt/mTOR/p70S6K pathway

Guo

Gao

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Spinal cord injury (SCI) is a grievous neurology-related disorder that causes many devastating symptoms. This research planned to dig the function and latent mechanisms of long noncoding RNA (lncRNA) ANRIL on hydrogen peroxide (H 2 O 2)-disposed injury in PC-12 cells. The PC-12 cells were disposed with H 2 O 2 for 24 h to construct the SCI model. H 2 O 2-disposed PC-12 cells was assessed by detecting cell viability, migration, invasion, apoptosis and autophagy. The level of ANRIL in H 2 O 2-disposed PC-12 cells was analysed, afterwards, the impacts of ANRIL silencing on H 2 O 2-disposed PC-12 cell injury was determined. The regulatory association between ANRIL and miR-499a, between miR-499a and PDCD4, as well as PDCD4 and PI3K/Akt/mTOR/p70S6K signals were investigated. H 2 O 2 produced PC-12 cell injury and promoted the level of ANRIL. Silencing of ANRIL inhibited H 2 O 2-disposed PC-12 cell injury through promoting cell viability, migration, invasion and inhibiting apoptosis and autophagy. Moreover, miR-499a was upregulated after silencing of ANRIL, and inhibition of miR-499a reversed the effects of silencing of ANRIL on H 2 O 2-disposed PC-12 cell injury. Also, PDCD4 was a target of miR-499a. Furthermore, ANRIL silencing alleviated the H 2 O 2-disposed injury in PC-12 cells possible by activating PI3K/Akt/mTOR/p70S6K signals, which was mediated by miR-499a/PDCD4 axis. Our results indicate that high level of ANRIL may sharpen the degree of SCI via targeting miR-499a/PDCD4 axis to regulate the briskness of PI3K/Akt/mTOR/p70S6K signals.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Overexpression of lncRNA ANRIL aggravated hydrogen peroxide-disposed injury in PC-12 cells via inhibiting miR-499a/PDCD4 axis-mediated PI3K/Akt/mTOR/p70S6K pathway

Guo

Gao

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…In particular, ADH7 expression levels gradually increased with an increase in patient age, while CYP26B1 expression gradually declined with a decrease in patient age, indicating that ADH7 and CYP26B1 are correlated with the differential progression of cervical cancer between different age groups. It has been revealed that miR-499a influences the tumorigenesis of several different types of cancer, including breast cancer (43) and hepatocellular carcinoma (44). In addition, miR-499a contributes to the migration and proliferation of hepatitis B virus-associated hepatocellular carcinoma (HCC) cells (45).…”

Section: Discussionmentioning

confidence: 99%

ADH7, miR‑3065 and LINC01133 are associated with cervical cancer progression in different age groups

et al. 2020

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The aim of the present study was to identify potential therapeutic targets that serve crucial roles in the progression of cervical cancer. Clinical data, RNA sequencing (RNAseq)-counts and micro (mi)RNA data regarding cervical squamous cell carcinoma were retrieved from The Cancer Genome Atlas, and analyses were performed using the University of California Santa Cruz database. RNAseq and miRNA data were stratified into 3 groups (according to the patients' age), and genes were re-annotated and preprocessed prior to Mfuzz time clustering analysis. Subsequently, enrichment analyses were performed in order to identify differentially expressed mRNAs (DEmRNAs) and a protein-protein interaction analysis network was constructed. miRNA-gene, miRNA-lncRNA, and long non-coding (lnc)RNA-mRNA pairs were collected and the lncRNA-miRNA-mRNA competing endogenous (ce)RNA network was established. Further enrichment analyses were performed in order to identify crucial mRNAs in the ceRNA network. Finally, survival and drug association analyses were implemented. A total of 269 DEmRNAs [including alcohol dehydrogenase 7 (ADH7), vestigial-like family member 3 (VGLL3) and cytochrome P450, family 26, subfamily B, polypeptide 1 (CYP26B1)], 274 DElncRNAs (including LINC01133) and 16 DEmiRNAs (including miR-3065 and miR-330) were identified. There were 102 lncRNAs, 15 miRNAs, 15 mRNAs and 522 interaction pairs in the ceRNA network. In particular, ADH7 was regulated by miR-3065, and miR-3065 interacted with LINC01133 in the ceRNA network. Furthermore, ADH7 and CYP26B1 were enriched in the retinoic acid metabolic process and the retinol metabolism pathway. ADH7 and VGLL3 were significantly associated with the cervical cancer survival rate. ADH7, VGLL3, CYP26B1, miR-3065, miR-330, miR-499a and LINC01133 play pivotal roles in the progression of cervical cancer in different age groups.

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“…Many epidemiological studies have examined the association between miRNA SNPs and cancer susceptibility [ 22 ]. In BC, several case-control studies and meta-analyses have evaluated the association between the miRNA gene polymorphisms and disease risk in European [ 24 , 25 , 26 , 27 , 28 , 29 ], Asian [ 30 , 31 ], Arab [ 32 ], Jewish [ 33 ], and Iranian populations [ 34 ]. With the exception of two studies, one in a Brazilian [ 35 ] and the other in Chilean population published by our group [ 36 ], the contribution of miRNA gene variants to BC risk among South American women remains unexplored.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the genetic variability is ethnicity-specific and appears to influence not only the risk but also the type of BC that develops in an individual. In this study, we selected SNPs in three miRNAs (rs3746444 in pre-miR-499, rs12975333 in pre-miR-125a, and rs2043556 in miR-605), based on the evidence in the literature for a relationship with BC risk [ 23 , 24 , 31 , 34 , 37 , 38 , 39 ]. Another four miRNAs (pre-miR-16, pre-miR-182, pre-miR-192, and pre-miR-146a) were also selected for analysis, as these miRNAs are known to target BRCA1/2 genes [ 40 , 41 , 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population

Morales

Mayo

Gulppi

et al. 2018

Genes

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Breast cancer (BC) is one of the most frequent tumors affecting women worldwide. microRNAs (miRNAs) single-nucleotide polymorphisms (SNPs) likely contribute to BC susceptibility. We evaluated the association of five SNPs with BC risk in non-carriers of the BRCA1/2-mutation from a South American population. The SNPs were genotyped in 440 Chilean BRCA1/2-negative BC cases and 1048 controls. Our data do not support an association between rs2910164:G>C or rs3746444:A>G and BC risk. The rs12975333:G>T is monomorphic in the Chilean population. The pre-miR-605 rs2043556-C allele was associated with a decreased risk of BC, both in patients with a strong family history of BC and in early-onset non-familial BC (Odds ratio (OR) = 0.5 [95% confidence interval (CI) 0.4–0.9] p = 0.006 and OR = 0.6 [95% CI 0.5–0.9] p = 0.02, respectively). The rs4541843-T allele is associated with increased risk of familial BC. This is the first association study on rs4541843 and BC risk. Previously, we showed that the TOX3-rs3803662:C>T was significantly associated with increased risk of familial BC. Given that TOX3 mRNA is a target of miR-182, and that both the TOX3 rs3803662-T and pri-miR-182 rs4541843-T alleles are associated with increased BC risk, we evaluated their combined effect. Risk of familial BC increased in a dose-dependent manner with the number of risk alleles (p-trend = 0.0005), indicating an additive effect.

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The SNP rs3746444 within mir-499a is associated with breast cancer risk in Iranian population

Cited by 14 publications

References 17 publications

RETRACTED ARTICLE: Overexpression of lncRNA ANRIL aggravated hydrogen peroxide-disposed injury in PC-12 cells via inhibiting miR-499a/PDCD4 axis-mediated PI3K/Akt/mTOR/p70S6K pathway

RETRACTED ARTICLE: Overexpression of lncRNA ANRIL aggravated hydrogen peroxide-disposed injury in PC-12 cells via inhibiting miR-499a/PDCD4 axis-mediated PI3K/Akt/mTOR/p70S6K pathway

ADH7, miR‑3065 and LINC01133 are associated with cervical cancer progression in different age groups

Genetic Variants in pre-miR-146a, pre-miR-499, pre-miR-125a, pre-miR-605, and pri-miR-182 Are Associated with Breast Cancer Susceptibility in a South American Population

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