The Socalled Senile Exfoliation (Pseudoexfoliation) of the Anterior Lens Capsule, a Product of the Lens Epithelium. Fibrillopathia Epitheliocapsularis

Bertelsen, Torstein; Drablös, Per Arne; Flood, Per R.

doi:10.1111/j.1755-3768.1964.tb03676.x

Cited by 100 publications

(57 citation statements)

References 28 publications

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“…The material was composed of numerous straight, irregularly outlined fibrils measuring 80-250 A in diameter, and they appeared identical to PE fibrils as seen in sections from intraocular tissue (Bertelsen et al 1964, Ashton et al 1965, Ringvold 1970). Only few membrane-bound granules were observed among the fibrils.…”

Section: Resultsmentioning

confidence: 87%

On the Occurrence of Pseudo‐exfoliation Material in Extrabulbar Tissue From Patients With Pseudo‐exfoliation Syndrome of the Eye

Ringvold

1973

Acta Ophthalmologica

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The present communication demonstrates pseudo‐exfoliation material in the palpebral conjunctiva of patients with pseudo‐exfoliation syndrome of the eye as determined by slit lamp examination. Biopsies of the skin or the oral mucous membrane of these patients did not reveal pseudo‐exfoliation material by electron microscopic investigation. Such material was also absent in conjunctival biopsies from patients without pseudo‐exfoliation syndrome of the eye. It is concluded that the pseudo‐exfoliation material in the mucous membrane of the eyelids is obviously not transported into this region from the intraocular space, and hence the occurrence of such material in this location indicates that pseudo‐exfoliation material is synthesized both in ocular and in extrabulbar tissue in patients with pseudo‐exfoliation syndrome of the eye.

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Section: Resultsmentioning

confidence: 87%

On the Occurrence of Pseudo‐exfoliation Material in Extrabulbar Tissue From Patients With Pseudo‐exfoliation Syndrome of the Eye

Ringvold

1973

Acta Ophthalmologica

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“…110 Despite involvement of the lens capsule in PXF, anterior and posterior capsule thickness and elasticity do not appear to be different from that in eyes without PXF. 111,112 This has implications for the ability and safety of capsular support devices in PXF. Preoperatively, the presence and degree of zonule weakness should be assessed and thorough preparation for and consideration of adjunctive surgical devices done before surgery.…”

Section: Intraoperative Issuesmentioning

confidence: 99%

Pseudoexfoliation and the cataract surgeon: Preoperative, intraoperative, and postoperative issues related to intraocular pressure, cataract, and intraocular lenses

Shingleton¹,

Crandall²,

Ahmed³

2009

Journal of Cataract and Refractive Surgery

150

131

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This review provides a comprehensive assessment of intraocular pressure (IOP), phacoemulsification techniques, and intraocular lenses (IOLs) in pseudoexfoliation (PXF) eyes having cataract surgery. Pseudoexfoliation is ubiquitous and the most common cause for open-angle glaucoma worldwide. Cataracts occur with increased frequency in PXF eyes, and surgery is potentially complicated by the presence of small pupils and zonule laxity and significantly affects IOP in these eyes. Preoperative evaluation and the options for intraoperative management of cataract are presented with recommendations for the use of adjunctive pupil and zonule support devices. Postoperative complications such as capsule contraction and IOL instability are discussed and laser and surgical options to manage these special problems presented.

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“…Special emphasis was laid upon examining the lens capsule at the peripheral band and in the pre-equatorial region. The two layers which may be found here, with their characteristic pattern of granules and fibrils (Bertelsen et al 1964, Ashton et al 1965, Dark et al 1969, were identified both by light and electron microscopy. Any penetration of peroxidase into the capsule was firmly ruled out.…”

Section: Resultsmentioning

confidence: 94%

Pseudo‐exfoliation Material on the Anterior Lens Surface. Demonstration and Examination of an Interfibrillar Ground Substance

Davanger

Pedersen

1975

Acta Ophthalmologica

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Peroxidase did not penetrate into the capsule of cataractous lenses with or without pseudo‐exfoliation (PE). Neither did this tracer penetrate into the PE material itself, indicating that the PE fibrils are embedded in a ground substance which is impenetrable to peroxidase. Staining with alcian blue and ruthenium red showed that this ground substance is structurally heterogeneous. Acid mucopolysaccharides and/or glycoproteins are probably present. The fibrils are coated by a material with affinity to ruthenium red. This applies also to the fibrils of the amorphous layer. Their diameter is only about 1/3 of the fibrils of the PE material on the lens surface. Rounded membrane‐covered bodies are present, partly in groups, in the PE material. Morphologically, they resemble the mucopolysaccharide‐containing lysosomal vacuoles found in systemic mucopolysaccharidoses. Observations supporting the conception of similarities between PE material and amyloid are pointed out. The pathogenesis of the PE material is discussed.

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The Socalled Senile Exfoliation (Pseudoexfoliation) of the Anterior Lens Capsule, a Product of the Lens Epithelium. Fibrillopathia Epitheliocapsularis

Cited by 100 publications

References 28 publications

On the Occurrence of Pseudo‐exfoliation Material in Extrabulbar Tissue From Patients With Pseudo‐exfoliation Syndrome of the Eye

On the Occurrence of Pseudo‐exfoliation Material in Extrabulbar Tissue From Patients With Pseudo‐exfoliation Syndrome of the Eye

Pseudoexfoliation and the cataract surgeon: Preoperative, intraoperative, and postoperative issues related to intraocular pressure, cataract, and intraocular lenses

Pseudo‐exfoliation Material on the Anterior Lens Surface. Demonstration and Examination of an Interfibrillar Ground Substance

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