The social and the psychological impact of endometriosis on the Romanian urban population

Baciu, Iulia; Irimie-Ana, Alecsandra; Panaitescu, Anca Maria; Peltecu, Gheorghe; Gică, Corina; Gică, Nicolae

doi:10.22543/7674.81.p120126

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…Chronic pain, fertility challenges, and reduced quality of life associated with endometriosis can lead to psychological distress and mood swings [28]. The bidirectional relationship between mood swings and endometriosis could potentially exacerbate symptom severity and impact disease progression [29,30]. These ndings emphasize the importance of integrating psychological support and mental health interventions in the management of endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between mood swing and gynecological disorders: a Mendelian randomization study

Bian,

Li,

Shang

et al. 2023

Preprint

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Background Increasing number of observational studies have associated mood instability to common female diseases, but the underlying causal relationship remains unclear. In this work, Mendelian randomization (MR) analysis was applied to explore the genetically predicted causal relationship of mood swings and several prevalent gynecological disorders. Methods Instrumental variables (IVs) of mood swings were selected from UK Biobank (UKB), with 204,412 cases and 247,207 controls being incorporated. The genetic variants for female disorders were obtained from genome-wide association studies (GWASs) and FinnGen consortium. To avoid biases caused by racial difference, only European population was included here. Five strong analytical methodologies were used to increase the validity of the results, the most substantial of which was the inverse variance weighting (IVW) method. Pleiotropy, sensitivity, and heterogeneity were assessed to strengthen the findings. Results We found mood swings was significantly positively associated with risk of endometrial cancer (OR = 2.60 [95%CI = 1.36, 4.95], P = 0.0037), cervical cancer (OR = 1.01[95%CI = 1.00,1.02], P = 0.0213) and endometriosis (OR = 2.58 [95%CI = 1.18, 5.60], P = 0.0170) by IVW method. However, there was no causal relationship between mood swing and ovarian cancer. No pleiotropy and heterogeneity existed and sensitivity tests were passed. Conclusion This study reveals genetically predicted causal relationships between mood swing and the risk of endometrial cancer, cervical cancer and endometriosis in European populations through MR analysis, which makes up for observational research's inherent limitations.

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Section: Discussionmentioning

confidence: 99%

Causal relationship between mood swing and gynecological disorders: a Mendelian randomization study

Bian,

Li,

Shang

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Causal Relationship Between Mood Swing and Gynecological Disorders: A Mendelian Randomization Study

Bian,

Li,

Shang

et al. 2024

IJWH

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Background Gynecological disorders are a wide range of health problems affecting the female reproductive system, which poses substantial health challenges worldwide. Increasing number of observational studies have associated mood instability to common female diseases, but the underlying causal relationship remains unclear. In this work, Mendelian randomization (MR) analysis was applied to explore the genetically predicted causal relationship of mood swings and several prevalent gynecological disorders. Methods Instrumental variables (IVs) of mood swings were selected from UK Biobank (UKB), with 204,412 cases and 247,207 controls being incorporated. The genetic variants for female disorders were obtained from genome-wide association studies (GWASs) and FinnGen consortium. To avoid biases caused by racial difference, only European population was included here. Five strong analytical methodologies were used to increase the validity of the results, the most substantial of which was the inverse variance weighting (IVW) method. Pleiotropy, sensitivity, and heterogeneity were assessed to strengthen the findings. Results We found mood swings was significantly positively associated with risk of endometrial cancer (OR= 2.60 [95% CI= 1.36, 4.95], P= 0.0037), cervical cancer (OR= 1.01[95% CI= 1.00,1.02], P= 0.0213) and endometriosis (OR= 2.58 [95% CI= 1.18, 5.60], P= 0.0170) by IVW method. However, there was no causal relationship between mood swing and ovarian cancer. No pleiotropy and heterogeneity existed and sensitivity tests were passed. Conclusion This study reveals that mood swing may serve as a genetically predicted causal risk factor for endometrial cancer, cervical cancer, and endometriosis in the European population, while no such association was observed for ovarian cancer. These findings make up for observational research’s inherent limitations and may improve patient outcomes in the field of gynecological health. However, the study’s focus on European populations may limit the applicability of these results globally.

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Impact of COVID-19 on Endometriosis Patients: An Integrative Review

Behboodi Moghadam,

Namazi

2025

CWHR

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Background: During the Covid-19 pandemic, people's lives worldwide have undergone extensive changes. The pandemic has worsened the condition of patients with chronic diseases like women with endometriosis. Objective: This study aims to summarize available evidence on the impact of the COVID-19 pandemic on physical symptoms, mental health, and medical care of patients with endometriosis. Methods: In the present integrative review using PRISMA guidelines, related articles published from December 2019 to July 2023 in databases including MEDLINE, Science Direct, Scopus, and Google Scholar in the English language were extracted. Results: After evaluating the criteria for inclusion and exclusion, a total of 23 articles were chosen and examined. This study represents an open window to investigate the impact of COVID-19 on women with endometriosis. The COVID-19 pandemic has affected the symptoms, mental well-being, and medical care of women with endometriosis. Conclusions: There is a perceived necessity to provide supportive care for patients during pandemic restrictions. Remote work has had an unanticipated advantage, and it is recommended that women with endometriosis continue to work from home after COVID-19 to maintain their workplace effectiveness.

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The social and the psychological impact of endometriosis on the Romanian urban population

Cited by 3 publications

References 16 publications

Causal relationship between mood swing and gynecological disorders: a Mendelian randomization study

Causal relationship between mood swing and gynecological disorders: a Mendelian randomization study

Causal Relationship Between Mood Swing and Gynecological Disorders: A Mendelian Randomization Study

Impact of COVID-19 on Endometriosis Patients: An Integrative Review

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