While studies of commerce and trade in Manila's ‘Golden Age’ are common, the impact of the city's multiethnic society on the daily lives of its inhabitants has often been harder to gauge. Based on 98 Inquisition cases, this article examines the widespread use of folk magic in colonial Manila, offering new insights into cultural interactions and inviting new reflections on the nature and extent of colonial domination. Folk magic—also known as hechicería—was an important part of cultural life within Spanish communities across the empire in the early modern period. Encompassing a variety of different practices, including the use of love charms, luck charms, spell-casting, and divination, it offered individuals opportunities to mediate their relationships, particularly with members of the opposite sex. These practices connected European folk traditions with Asian knowledge of botany, medicine, and spirituality to fulfil the needs of the Spanish community for magic. At the same time, this blending of Spanish and Asian cultures was subversive of colonial authority. Folk magic practices challenged the progression of ‘pious imperialism’ that pitted Christianity against indigenous traditions, creating spaces of cultural exchange where the balance of power between cultures was more evenly felt than often assumed.