The remains of an exceptionally well-preserved Hellenistic wine press were uncovered during a rescue excavation at Knossos in 1977. The architecture, stratigraphy and faunal remains from this campaign were published in BSA 89 (1994) by J. Carington Smith (the excavator) and S. Wall. The artefact assemblages from this excavation, however, have remained unstudied and unpublished until now. The current article presents the artefact assemblages from the wine press excavation and considers them within their urban context at Knossos. The key findings from this excavation relate to the Late Hellenistic wine press and its associated material, which enables us to consider both the ancient winemaking process at Knossos and the economic topography of the city in the decades around the Roman conquest of the island in 67 bc. In addition to the Late Hellenistic phase, material of Minoan, Early Iron Age–Early Archaic, earlier Hellenistic and Early Roman dates is also presented and discussed.