The Sociodemographic and Risk Factors for Keratoconus: Nationwide Matched Case-Control Study in Taiwan, 1998-2015

Lin, Ken‐Kuo; Js, Lee; Hou, Chiun‐Ho; Chen, Weimin; Hsiao, Ching-Hsi; Chen, Yun-Wen; Yeh, Chih-Ting; See, Lai‐Chu

doi:10.1016/j.ajo.2020.09.040

Cited by 28 publications

(27 citation statements)

References 48 publications

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“…Fourth, the sample sizes for the four ocular diseases were small, especially for patients with refractive error, KC, and AMD. For KC, the male: female ratio (60:40) in this study was similar to that of the KC population in Taiwan (59.7:40.8), but the mean age in this study (37.9 years) was older than that of the KC population in Taiwan (29.7 years) [ 46 ]. For senior cataracts, the mean age (68.3 years) and the male: female ratio (45.9:54.1) in this study were similar to those of the cataract population in Taiwan (69.6 years, 46.5:53.5) [ 47 ].…”

Section: Discussionmentioning

confidence: 62%

Chinese Version of the Vision-Related Quality of Life (NEI-VFQ-25) among Patients with Various Ocular Disorders: A Pilot Study

Lin

Hou

et al. 2022

Medicina

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Background and Objectives: Subjective visual function is currently becoming an increasing appreciation in assessing the health-related quality of life. This study aimed to assess the vision-related quality of life (VRQOL) among patients with refractive errors, keratoconus, senile cataract, and age-related macular degeneration (AMD) using the Chinese version of the National Eye Institute Visual Function Questionnaire 25 (NEI-VFQ-25). Materials and Methods: The questionnaire of NEI-VFQ-25 was filled out in a clinical setting or by telephone/mail. Univariate and multivariate analyses were used to determine which factors are associated with the NEI-VFQ-25. Results: From June 2018 to January 2019, 28 patients with refractive error, 20 patients with keratoconus, 61 with senile cataracts, and 17 with AMD completed the questionnaire NEI-VFQ-25. There were significant differences in the NEI-VFQ-25 subscale of general vision (p = 0.0017), ocular pain (p = 0.0156), near activities (p = 0.0002), vision-specific social functioning (p = 0.007), vision-specific mental health (p = 0.0083), vision-specific dependency (p = 0.0049), color vision (p < 0.0001), peripheral vision (p = 0.0065), and total score (p < 0.0001) among four disease groups, respectively. The multiple linear regression revealed that the best-corrected visual acuity (BCVA) and disease group were important factors of the total NEI-VFQ-25. After adjusting for BCVA, patients with AMD had a worse total NEI-VFQ-25 score than patients with refractive error, keratoconus, or senile cataracts. Conclusions: Among the patients with four ocular disorders and a broad vision spectrum from normal, partial sight, low vision to legal blindness, the BCVA of their better eye was the most important factor in the VRQOL.

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Section: Discussionmentioning

confidence: 62%

Chinese Version of the Vision-Related Quality of Life (NEI-VFQ-25) among Patients with Various Ocular Disorders: A Pilot Study

Lin

Hou

et al. 2022

Medicina

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“…This may pose a problem in clinical practice. Keratoconus has been associated with atopic dermatitis, Down syndrome, sleep apnea syndrome, and eye rubbing [29][30][31][32][33]. Future research should aim to further increase KKI specificity by considering other parameters and contributing factors.…”

Section: Discussionmentioning

confidence: 99%

Screening of Keratoconus Using Autokeratometer and Keratometer Keratoconus Index

et al. 2021

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The keratometer keratoconus index (KKI) is a diagnostic index for the risk of keratoconus calculated from autokeratometer test values. We partially modified the KKI equation and assessed it without limiting the target age and severity of keratoconus. This retrospective study included 179 eyes of 99 patients with keratoconus and 468 eyes from 235 normal controls. In the modified KKI, oblique astigmatism or against-the-rule astigmatism was defined as ≥1D astigmatism. KKI diagnostic power was analyzed in subgroups of <50 and ≥50-year-old patients, and at different keratoconus stages. Although the sensitivity of modified KKI was comparable with that of original KKI (92.7% vs. 95.5%), modified KKI specificity was significantly higher (79.7% vs. 68.6%) (p = 0.0001). Using the modified KKI, sensitivity reached 100% (4/4) and specificity, 63.5% (33/52), in ≥50-year-old patients, while overall sensitivity in keratoconus ≥stage 2 was 100% (30/30). In conclusion, the modified KKI proved to be effective in keratoconus screening at all stages. However, it should be noted that false-positive frequency is higher in ≥50-year-old patients.

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“…A meta-analysis of one cohort and four case–control studies showed a significant association between KC and OSA (pooled OR: 1.841, p = 0.009) [ 107 ]. See et al conducted a nationwide population-based matched case–control study and found no significant association between KC and SA [ 108 ]. Topographic and biomechanical corneal variations (corneal volume, corneal elevation, and minimum radius) [ 109 ], as well as greater pleomorphism and polymegathism of the corneal endothelium [ 110 ], were found in severe OSA when compared to healthy subjects.…”

Section: Osa-associated Complications In Anterior Segment Of Eyementioning

confidence: 99%

Ocular Complications of Obstructive Sleep Apnea

Liu

Chiu

Wang

et al. 2021

JCM

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Obstructive sleep apnea (OSA), the most common form of sleep-disordered breathing, is characterized by repetitive episodes of paused breathing during sleep, which in turn induces transient nocturnal hypoxia and hypercapnia. The high prevalence of OSA and its associated health consequences place a heavy burden on the healthcare system. In particular, the consequent episodic oxygenic desaturation/reoxygenation series and arousals from sleep in patients with OSA have the potential to trigger oxidative stress, elevated systemic inflammatory responses, and autonomic dysfunction with sympathetic activation. Given these adverse side-effects, OSA is highly correlated to many eye diseases that are common in everyday ophthalmic practices. Some of these ocular consequences are reversible, but they may permanently threaten a patient’s vision if not treated appropriately. Here, this article seeks to review the ocular consequences and potential pathophysiologic associations in patients with OSA. Understanding these OSA-related eye diseases may help clinicians provide comprehensive care to their patients.

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The Sociodemographic and Risk Factors for Keratoconus: Nationwide Matched Case-Control Study in Taiwan, 1998-2015

Cited by 28 publications

References 48 publications

Chinese Version of the Vision-Related Quality of Life (NEI-VFQ-25) among Patients with Various Ocular Disorders: A Pilot Study

Chinese Version of the Vision-Related Quality of Life (NEI-VFQ-25) among Patients with Various Ocular Disorders: A Pilot Study

Screening of Keratoconus Using Autokeratometer and Keratometer Keratoconus Index

Ocular Complications of Obstructive Sleep Apnea

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