The sodium and potassium content of cardiac and other tissues of the ox

Davies, Francis; Davies, R. E.; Francis, E. T. B.; Whittam, R.

doi:10.1113/jphysiol.1952.sp004792

Cited by 39 publications

(13 citation statements)

References 7 publications

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“…The results with the myocardium are similar to those of others, and the results with the Purkinje tissue, while differing from those with the myocardium, are similar to those of others with other specialized cardiac tissues (9)(10)(11). Both the Purkinje and the myocardial samples were taken from the same animals and subjected simultaneously to the same procedures.…”

Section: Myocardial Tissuesupporting

confidence: 85%

“…Accepted for publication June 22, 1970. sodium within the cell and in intracellular space larger than the extracellular space (1)(2)(3)(4)(5)(6)(7)(8). There have been reports that in specialized cardiac tissues, such as sinus venosus, sinoatrial node, atrioventricular node, and bundle of His, the total tissue concentration of sodium exceeds that of potassium (9)(10)(11). These findings raise the possibility that the intracellular concentration of sodium is unusually high and the intracellular concentration of potassium is unusually low in these tissues-a condition to which their special electrophysiological properties may be related -or that the principally sodium-containing 160 VICK, HAZLEWOOD, NICHOLS extracellular space is larger, and the principally potassium-containing intracellular space is smaller, than in most other tissues.…”

mentioning

confidence: 98%

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Distribution of Potassium, Sodium, and Chloride in Canine Purkinje and Ventricular Tissues

Vick

Hazlewood

Nichols

1970

Circulation Research

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Cellular resting and action potentials and total tissue concentrations of K + , Na + , and Ch were measured in canine myocardial and Purkinje tissues. The results with myocardium were consistent with those of others: the total tissue concentration of K + was greater than that of Na + of Ch. In Purkinje tissue, the total tissue concentration of K + was relatively low, while that of Na + and of Ch was high. Extracellular space was calculated on the basis of four different assumptions about the intracellular concentration of one of the ions: (1) the intracellular concentrations of Ch is zero; (2) the electrochemical equilibrium potential of Ch equals the cellular resting potential; (3) the electrochemical equilibrium potential of K + equals the cellular maximum diastolic potential; (4) the electrochemical equilibrium potential of Na + equals the reversal of the cellular action potential. In the myocardium, the lowest estimate of extracellular space was 14 ± 2%, and the highest was 18 ± 2%. In the Purkinje tissue, the minimum extracellular space: (1) permitting adequate intracellular K + to account for the maximum diastolic potential was 45 ± 3%; (2) consistent with passive distribution of Ch was 61 ± 4%; (3) yielding low enough intracellular concentration of Na + to account for the reversal of the action potential was 63 ± 10%. These results suggest that in cardiac Purkinje tissue:(1) the extracellular space is unusually large with respect to that of myocardium and skeletal muscle; (2) intracellular activities of ions do not necessarily equal concentrations; or (3) intracellular space is not necessarily a single compartment.ADDITIONAL KEY WORDS myocardium cardiac Purkinje tissue resting potential maximum diastolic potential action potential extracellular space intracellular concentrations of ions • In skeletal muscle and myocardium, the total tissue concentration of potassium usually exceeds that of sodium. This is consistent with a higher concentration of potassium than of From the

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Section: Myocardial Tissuesupporting

confidence: 85%

mentioning

confidence: 98%

Distribution of Potassium, Sodium, and Chloride in Canine Purkinje and Ventricular Tissues

Vick

Hazlewood

Nichols

1970

Circulation Research

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“…Na and K total in intact nerves Several authors have commented previously on the high content in mammalian nervous tissue of Na and K, which is particularly striking when it is considered that nervous tissue contains only some 60-70 % water (e.g. Davies et al 1952;Harris & McLennan, 1953). In the present case, the Na plus K total amounted to 142 m-mole/kg in fresh cat nerves, which is equivalent to about 210 m-mole/kg nerve water.…”

Section: Na and K Content Of Desheathed Nervesmentioning

confidence: 99%

The distribution of Na and K in cat nerves

Krnjević¹

1955

The Journal of Physiology

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Ever since the first full statement of the membrane theory (Bernstein, 1912) it has been widely believed that the mechanism of nervous conduction depends upon certain important differences between the concentrations of electrolytes inside and outside the nerve fibre. Bernstein had no evidence on this point and he relied for his argument on what evidence was available from analyses of muscle. We now know much about the composition of the intracellular fluid of invertebrate nerves (e.g. Lewis, 1952) and one analysis has been made of the electrolyte distribution in frog nerves (Fenn, Cobb, Hegnauer & Marsh, 1934). No study of the distribution of electrolytes in mammalian nerves, however, is apparently available.Estimations of the total content of Na, K and Cl in various mammalian (1954): Na and K. The information to be derived from these values is unfortunately greatly limited by complete uncertainty about the relative proportions of intra-and extracellular fluid and the relative proportions of total intra-and extracellular Na, K, or Cl. The present paper is an analysis of the distribution of Na, K and Cl in cat nerves, based upon: (a) a comparison of the total Na, K and Cl contents of intact nerve trunks and desheathed nerve bundles; (b) studies of the diffusion of Na from desheathed nerve bundles; (c) a direct estimate of the intracellular space obtained from photomicrographs. METHODSAnimals. Most of the nerves analysed were from cats. A small number of nerves from rabbits, dogs and monkeys were also studied for comparison; the only estimations made, however, were of the total Na and K.The majority of the nerves were removed from cats which were in good condition, with their circulation intact, in the course of experiments under general anaesthesia, or in some cases, after * Beit Memorial Research Fellow.

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“…Enzyme studies have been made by some other investi gators (Yamazaki, 1929;Mommaerts et al, 1953 andKrokhina et al" 1963), the most interesting fact here is that the cholinesterase content in the conducting system is as high as in a nerve. Investi gations on the sodium and potassium content have been published by Davies et al (1952). Mallow et al (1952Mallow et al ( , 1953 and Yamazaki (1930) have analysed the fact components of the conducting system.…”

Section: Introductionmentioning

confidence: 99%

Studies of the Chemical Components of the Conducting System of the Heart

Helander¹

1965

Cardiology

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The sodium and potassium content of cardiac and other tissues of the ox

Cited by 39 publications

References 7 publications

Distribution of Potassium, Sodium, and Chloride in Canine Purkinje and Ventricular Tissues

Distribution of Potassium, Sodium, and Chloride in Canine Purkinje and Ventricular Tissues

The distribution of Na and K in cat nerves

Studies of the Chemical Components of the Conducting System of the Heart

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