The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure

Vincent, Jean Louis; Moreno, Rui P.; Takala, Jukka; Willatts, Sheila M.; Mendon�a, A. De; Bruining, H. A.; Reinhart, C. K.; Pm, Suter; Thijs, L. G.

doi:10.1007/s001340050156

Cited by 484 publications

(495 citation statements)

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“…Organ dysfunction was assessed using the Sequential Organ Failure Assessment (SOFA) score19. The SOFA score was recorded before DL, and at 6, 24, 72 and 168 h thereafter.…”

Section: Methodsmentioning

confidence: 99%

Decompressive laparotomy for abdominal compartment syndrome

Waele

Kimball

Malbrain

et al. 2016

British Journal of Surgery

101

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BackgroundThe effect of decompressive laparotomy on outcomes in patients with abdominal compartment syndrome has been poorly investigated. The aim of this prospective cohort study was to describe the effect of decompressive laparotomy for abdominal compartment syndrome on organ function and outcomes.MethodsThis was a prospective cohort study in adult patients who underwent decompressive laparotomy for abdominal compartment syndrome. The primary endpoints were 28‐day and 1‐year all‐cause mortality. Changes in intra‐abdominal pressure (IAP) and organ function, and laparotomy‐related morbidity were secondary endpoints.ResultsThirty‐three patients were included in the study (20 men). Twenty‐seven patients were surgical admissions treated for abdominal conditions. The median (i.q.r.) Acute Physiology And Chronic Health Evaluation (APACHE) II score was 26 (20–32). Median IAP was 23 (21–27) mmHg before decompressive laparotomy, decreasing to 12 (9–15), 13 (8–17), 12 (9–15) and 12 (9–14) mmHg after 2, 6, 24 and 72 h. Decompressive laparotomy significantly improved oxygenation and urinary output. Survivors showed improvement in organ function scores, but non‐survivors did not. Fourteen complications related to the procedure developed in eight of the 33 patients. The abdomen could be closed primarily in 18 patients. The overall 28‐day mortality rate was 36 per cent (12 of 33), which increased to 55 per cent (18 patients) at 1 year. Non‐survivors were no different from survivors, except that they tended to be older and on mechanical ventilation.ConclusionDecompressive laparotomy reduced IAP and had an immediate effect on organ function. It should be considered in patients with abdominal compartment syndrome.

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“…Organ dysfunction was assessed using the Sequential Organ Failure Assessment (SOFA) score19. The SOFA score was recorded before DL, and at 6, 24, 72 and 168 h thereafter.…”

Section: Methodsmentioning

confidence: 99%

Decompressive laparotomy for abdominal compartment syndrome

Waele

Kimball

Malbrain

et al. 2016

British Journal of Surgery

101

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“…Under this new definition, sepsis refers to infection (including suspected infection) accompanying organ dysfunction with a SOFA score of two or higher 454. However, no pediatric SOFA score system currently exists.…”

Section: Cq19: Pediatric Considerationsmentioning

confidence: 99%

“…When assessing organ dysfunction based on SOFA score,454 the normal upper limit threshold value for pediatric patients is adjusted to 0 points, and the following four items are multiplied by several numerical values according to the SOFA score454 (Table 6). The appropriateness of this method must be verified in the future.…”

Section: Cq19: Pediatric Considerationsmentioning

confidence: 99%

“…However, this new definition only applies to adult patients, and to date there has been no movement by any nation towards establishing a definition specific to pediatric patients. Meanwhile, there have been no concrete efforts to accumulate and analyze clinical data from pediatric sepsis patients, making it difficult to propose a new definition of sepsis that also conforms to the Sequential Organ Failure Assessment (SOFA) criteria for adult sepsis patients 454. As such, currently, the description of “infection‐induced systemic inflammatory response syndrome (SIRS)” based on the criteria and definition proposed by Goldstein et al .…”

Section: Introductionmentioning

confidence: 99%

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The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

Nishida

Ogura

Egi

et al. 2018

Acute Medicine & Surgery

157

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Background and PurposeThe Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG 2016), a Japanese‐specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 in Japanese. An English‐language version of these guidelines was created based on the contents of the original Japanese‐language version.MethodsMembers of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ), and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two‐thirds (>66.6%) majority vote of each of the 19 committee members.ResultsA total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J‐SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation and its supporting evidence were also added to each recommendation statement. We conducted meta‐analyses for 29 CQs. Thirty seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for 5 CQs.ConclusionsBased on the evidence gathered, we were able to formulate Japanese‐specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non‐specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals.

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“…Sepsis is defined as life‐threatening organ dysfunction caused by a dysregulated host response to infection. Organ dysfunction was identified as an acute change in total Sequential Organ Failure Assessment score2 (SOFA) of ≥2 as a consequence of the infection (Table 1). …”

Section: Introductionmentioning

confidence: 99%

Mechanisms of sepsis‐induced immunosuppression and immunological modification therapies for sepsis

Ono

Tsujimoto

Hiraki

et al. 2018

Annals of Gastroent Surgery

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Surgical injury can be a life‐threatening complication, not only due to the injury itself, but also due to immune responses to the injury and subsequent development of infections, which readily result in sepsis. Sepsis remains the leading cause of death in most intensive care units. Unfavorable outcomes of several high‐profile trials in the treatment of sepsis have led researchers to state that sepsis studies need a new direction. The immune response that occurs during sepsis is characterized by a cytokine‐mediated hyper‐inflammatory phase, which most patients survive, and a subsequent immunosuppressive phase. Therefore, therapies that improve host immunity might increase the survival of patients with sepsis. Many mechanisms are responsible for sepsis‐induced immunosuppression, including apoptosis of immune cells, increased regulatory T cells and expression of programmed cell death 1 on CD4+ T cells, and cellular exhaustion. Immunomodulatory molecules that were recently identified include interleukin‐7, interleukin‐15, and anti‐programmed cell death 1. Recent studies suggest that immunoadjuvant therapy is the next major advance in sepsis treatment.

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The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure

Cited by 484 publications

References 0 publications

Decompressive laparotomy for abdominal compartment syndrome

Decompressive laparotomy for abdominal compartment syndrome

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

Mechanisms of sepsis‐induced immunosuppression and immunological modification therapies for sepsis

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