The Solitary Bone Metastasis as a First Sign of Papillary Thyroid Cancer

Abstract

Context. Tumors associated with thyroid gland are relatively rare. Papillary thyroid cancer (PTC) represents the most frequent thyroid neoplasm, and it has almost in all of the cases favorable prognosis. In the largest number of the cases, PTC remains within the thyroid gland or it gives the lymphogenic metastasis in the cervical lymph nodes and, extremely rare, it results in hematogenic metastasis.Objective. To present a case of a patient who had a distant secondary deposit in pelvic bone and sacral bone as a first sign of the PTC. Subjects and Methods.A 56 year old male was presented in this report. Results. After intensive hip pain, patient was diagnosed with osteolytic lesion in sacral and left pelvic bone. After aspiration biopsy, macroscopic analysis and imunohistochemistry, diagnosis of PTC was set. Patient has undergone total thyroidectomy, two doses of radioiodine were applied and secondary deposit palliative radiotherapy as well.Conclusions. The total thyroidectomy is the first line therapy in the PTC patients for primary tumors, while the therapy for the secondary deposits requires surgical procedures combined with other means of treatment.

Skull Metastasis as the Presenting Feature of Mixed Medullary and Follicular Thyroid Carcinoma

“…Synchronous metastasis has been reported to occur in 40-75% patients of thyroid cancer, most commonly to cervical lymph nodes (2,10). Bone metastasis as the presenting feature of thyroid carcinoma is rare (11). Patients with bone metastasis have a 5 and 10-year survival of around 53% and 38% respectively, (12) which is significantly lower than the 10-year survival in PTC and FTC without metastasis (74-93% and 43-94% respectively) (13).…”