The solvent free preparation of beta-amino esters alpha,beta-unsaturated ketones and esters with domestic microwave oven

Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing

“…The glycine ethyl ester head group in 26 was synthesized as previously reported, 75 and commercially available alanine methyl ester was utilized to synthesize 27 . Library B was synthesized using EDC couplings and purified as previously reported.…”

Synthesis of tritium‐labeled levetiracetam ((2S)‐2‐(2‐oxopyrrolidin‐1‐yl)butanamide) with high specific activity

“…A suitable LEV precursor (compound 6 ; see Scheme ) was prepared for radiolabeling, which would allow for the introduction of four tritium atoms by catalytic hydrogenation. Thus, ( S )‐2‐aminobutyric acid 2 was reacted with thionyl chloride in methanol to yield the methyl ester 3 in nearly quantitative yield . The methyl ester was then transformed to the corresponding amide 4 in a microwave reaction using ammonia in methanol.…”

Green methodologies in organic synthesis: Microwave assisted solvent- and catalyst-free synthesis of enaminones and their conversion into 1,3,5-trisubstituted benzenes as well as 3-aroyl-6-substituted pyridines

“…However several authors have reported that yields are quite low according to this protocol [10]. Domestic microwave irradiation has already been described in the preparation of enaminones by Braibante et al [11,12] and by Hamelin et al [13], in both cases, either a solid support or an acid catalyst was employed as reaction promoter. Lee et al [14] reported a solvent-free microwave assisted preparation of enaminones in a microwave (MW) reactor, using catalytic HCl and an excess of the amines.…”