The Sorption of Soluble Dyes by Gelatin.

Abstract

Communication No. 811 from the Kodak Research Laboratories.* This is shown not only by the observations on the "washing out'' of comparable dyes noted in this paper but also by investigations now in process on the diffusion of cyanine dyes in gelatin jellies.

The Influence of Formulation and Manufacturing Process Parameters on the Characteristics of Lyophilized Orally Disintegrating Tablets

“…The 2-dimensional porous structure of the freeze-dried tablets of the formulation adjusted to pH 8, appeared to exhibit greater average pore diameter (100–140 μm) and thinner average pore wall thickness (20 μm) ( Figure 2a , b ), compared to the freeze-dried tablets of the control formulation (average pore diameter of 90 μm, and average pore wall thickness of 40 μm), as shown in Figures 3a and 3b . This observation can be attributed to the swelling behavior of gelatin at pH 8 [ 10 ] that results in the formation of larger pores with thinner walls.…”

“…A pH-swelling curve for lime processed gelatin (type B) has been reported [10]. The results showed that adjusting the pH away from the isoelectric point resulted in a significant swelling of the material.…”

“…Interestingly, studies investigating molecular variations in gelatin configuration have shown that various factors such as pH and salt concentration influence its packing and solubility. A pH-swelling curve for lime processed gelatin (type B) has been reported [ 10 ]. The results showed that adjusting the pH away from the isoelectric point resulted in a significant swelling of the material.…”

Thermo-reversibility, ergodicity and surface charge–temperature dependent phase diagram of anionic, cationic and neutral co-gels of gelatin–BSA complexes

“…At neutral pH, therefore, the protein maintains a well-dened overall conformation. 61 When the mixture of BSA and gelatin was prepared at different pH (¼3, 5, 7) at room temperature, the mixture remained homogeneous, but turned into a gel-like phase over a period of time. At acidic (pH ¼ 3) and basic (pH ¼ 7) gelatin coil repel each other, and BSA will appear to be expanded, and assume basic form (E and B forms) to the full extent so network in that condition will be of low visco-elasticity.…”

“…55,56 The B isomerization is supposed to be a structural uctuation, a loosening of the molecule with loss of rigidity, particularly affecting the Nterminal region and thereby impacting ligand binding ability. [59][60][61] The stable structure of gelatin as it is found under "normal" conditions is that of long tightly coiled chain. In this state the gelatin is close to its isoelectric point (IEP), and the pH is around 4.8.…”