The sour side of vitamin C might mediate neuroprotective, anticonvulsive and antidepressant-like effects

Bonnet, Udo

doi:10.1016/j.mehy.2019.109320

Cited by 15 publications

(9 citation statements)

References 53 publications

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“…Moreover, vitamin C is present in the brain in high concentrations, participating in processes such as neuronal differentiation, maturation, and survival, dopamine and norepinephrine biosynthesis, neurotransmission modulation, and neuronal protection against glutamate toxicity [105,110]. However, by contrast to most mammals that produce vitamin C from glucose in the liver, humans cannot synthesize it due to the lack of L-gulonolactone enzyme and are dependent on dietary sources [105,111].…”

Section: Antioxidants For Neuroprotectionmentioning

confidence: 99%

Antioxidant Therapies for Neuroprotection—A Review

Teleanu

Chircov

Grumezescu

et al. 2019

JCM

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Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between the production and accumulation of ROS and the ability of the body to neutralize and eliminate them. In the brain, oxidative stress exhibits significant effects, due to its increased metabolical activity and limited cellular regeneration. Thus, oxidative stress is a major factor in the progressive loss of neurons structures and functions, leading to the development of severe neurodegenerative disorders. In this context, recent years have witnessed tremendous advancements in the field of antioxidant therapies, with a special emphasis for neuroprotection. The aim of this paper is to provide an overview of the oxidative stress and antioxidant defense mechanisms and to present the most recent studies on antioxidant therapies for neuroprotection.

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Section: Antioxidants For Neuroprotectionmentioning

confidence: 99%

Antioxidant Therapies for Neuroprotection—A Review

Teleanu

Chircov

Grumezescu

et al. 2019

JCM

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“…Ascorbic acid (AA) or vitamin C is water-soluble hexanoic sugar acid required for the normal healthy functioning and repair of every tissue type, mainly due to its function as a key endogenous antioxidant and a cofactor for enzymatic reactions [138,139]. Many animals can produce AA from glucose in the liver.…”

Section: Ascorbic Acid (Aa): Structure-functionmentioning

confidence: 99%

“…From the neuronal perspective, AA can act both as a neuromodulator [201][202][203] and a neuroprotectant [139,178,180]. The modulation of neurotransmission by AA is known to occur at cholinergic, catecholaminergic, and glutamatergic synapses, wherein it can influence neurotransmitter release, binding, and uptake, and serves as a cofactor for their biosynthesis [204].…”

Section: Aa In the Brainmentioning

confidence: 99%

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(Ascorb)ing Pb Neurotoxicity in the Developing Brain

Ahmad

Liu

2020

Antioxidants

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Lead (Pb) neurotoxicity is a major concern, particularly in children. Developmental exposure to Pb can alter neurodevelopmental trajectory and has permanent neuropathological consequences, including an increased vulnerability to further stressors. Ascorbic acid is among most researched antioxidant nutrients and has a special role in maintaining redox homeostasis in physiological and physio-pathological brain states. Furthermore, because of its capacity to chelate metal ions, ascorbic acid may particularly serve as a potent therapeutic agent in Pb poisoning. The present review first discusses the major consequences of Pb exposure in children and then proceeds to present evidence from human and animal studies for ascorbic acid as an efficient ameliorative supplemental nutrient in Pb poisoning, with a particular focus on developmental Pb neurotoxicity. In doing so, it is hoped that there is a revitalization for further research on understanding the brain functions of this essential, safe, and readily available vitamin in physiological states, as well to justify and establish it as an effective neuroprotective and modulatory factor in the pathologies of the nervous system, including developmental neuropathologies.

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“…Second, enhancing the spinal descending inhibitory pathway is another possible mechanism of vitamin C to reduce HZ-associated pain [ 37 ]. One critical mechanism of neuropathic pain in spontaneous pain is disinhibition, which is mediated by the spinal descending inhibitory pathway [ 38 ].…”

Section: Literature Reviewmentioning

confidence: 99%

Intravenous Administration of Vitamin C in the Treatment of Herpes Zoster-Associated Pain: Two Case Reports and Literature Review

Liu

Wang

Xiong

et al. 2020

Pain Research and Management

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Background. Herpes zoster (HZ) is an acute inflammatory neurocutaneous disease caused by the reactivation of varicella-zoster virus. It is estimated that the incidence of postherpetic neuralgia following HZ is 10–20%. The leading risk factors of the prognosis are aging and immunity dysfunction. Vitamin C plays a pivoted role in enhancing white blood cell function. Epidemiological evidence and clinical studies have indicated an association between pain and suboptimal vitamin C status. At present, vitamin C has been used as an additional option in the treatment of HZ-associated pain. Despite the current controversy, case reports and randomized controlled studies have indicated that both acute- and postherpetic neuralgia can be dramatically alleviated following intravenous vitamin C infusions. Case Presentation. Two patients (male aged 72 and female 78 years) with HZ did not respond well to antiviral therapy and analgesics. Skin lesions in the right groin and front thigh healed after early antiviral therapy, but the outbreak of pain persisted in the male patient. The female patient presented to our clinic with clusters of rashes in the right forehead with severe edema of her right upper eyelid. Because nerve blockade could not be conducted for both patients, intravenous infusion of vitamin C was applied and resulted in an immediate remission of the breakthrough pain in the male patient and cutaneous lesions in the female patient. Conclusions. The use of vitamin C appears to be an emerging treatment alternative for attenuating HZ and PHN pain. Hence, we recommend the addition of concomitant use of intravenously administered vitamin C into therapeutic strategies in the treatment of HZ-associated pain, especially for therapy-resistant cases. Furthermore, animal studies are required to determine analgesic mechanisms of vitamin C, and more randomized clinical trials are essential to further determine the optimal dose and timing of administration of vitamin C.

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The sour side of vitamin C might mediate neuroprotective, anticonvulsive and antidepressant-like effects

Cited by 15 publications

References 53 publications

Antioxidant Therapies for Neuroprotection—A Review

Antioxidant Therapies for Neuroprotection—A Review

(Ascorb)ing Pb Neurotoxicity in the Developing Brain

Intravenous Administration of Vitamin C in the Treatment of Herpes Zoster-Associated Pain: Two Case Reports and Literature Review

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