The Southern European Atlantic Diet and Its Supplements: The Chemical Bases of Its Anticancer Properties

Abstract

Scientific evidence increasingly supports the strong link between diet and health, acknowledging that a well-balanced diet plays a crucial role in preventing chronic diseases such as obesity, diabetes, cardiovascular issues, and certain types of cancer. This perspective opens the door to developing precision diets, particularly tailored for individuals at risk of developing cancer. It encompasses a vast research area and involves the study of an expanding array of compounds with multilevel “omics” compositions, including genomics, transcriptomics, proteomics, epigenomics, miRNomics, and metabolomics. We review here the components of the Southern European Atlantic Diet (SEAD) from both a chemical and pharmacological standpoint. The information sources consulted, complemented by crystallographic data from the Protein Data Bank, establish a direct link between the SEAD and its anticancer properties. The data collected strongly suggest that SEAD offers an exceptionally healthy profile, particularly due to the presence of beneficial biomolecules in its foods. The inclusion of olive oil and paprika in this diet provides numerous health benefits, and scientific evidence supports the anticancer properties of dietary supplements with biomolecules sourced from vegetables of the brassica genus. Nonetheless, further research is warranted in this field to gain deeper insights into the potential benefits of the SEAD’s bioactive compounds against cancer.

Phytochemical Profile, Antioxidant and Cytotoxic Potential of Capsicum annuum (L.) Dry Hydro-Ethanolic Extract

“…A recent study [ 44 ] showed the cytotoxic effects of C. annuum extracts on various tumor cell lines: breast cancer (MDA-MB-231 and MCF-7), pancreatic cancer (PANC-1, pancreatic ductal adenocarcinoma), skin cancer (A375, human melanoma), and lymphoblastic (K562, myelogenous leukemia). The highest cytotoxicity (IC 50 = 153.18 µg/mL) was recorded on PANC-1 cells.…”

Bioactivity of benzophenazine enaminone derivatives as inhibitors of ERK2 based on molecular docking and dynamics simulation studies

“…These methods were employed to predict the binding affinity of the molecules to a protein known as ERK2, which is associated with skin cancer. 31–34 It should be noted that the selection of ERK2 as the target protein for investigating benzophenazine enaminone derivatives as inhibitors is grounded in its significance in cancer, suitability for drug targeting, prior research outcomes, and specificity. This choice represents a logical and scientifically justified strategy in the endeavor to develop potential therapeutic agents for treating cancer.…”