The sox gene Dichaete is expressed in local interneurons and functions in development of the Drosophila adult olfactory circuit

Melnattur, Krishna; Berdnik, Daniela; Rusan, Zeid M.; Ferreira, Christopher J.; Nambu, John R.

doi:10.1002/dneu.22038

Cited by 3 publications

(3 citation statements)

References 62 publications

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“…The odd paired (opa) protein is important during embryonic segmentation, midgut formation and adult head morphogenesis 22 . The Dichaete (D) has important role in many developmental processes like neurogenesis, hindgut development, segmentation, and proper adult structure formation [23][24][25] . The cluster 11 with negative peak at the zoea I stage do not have any signi cantly expressed TFs or enrichment processes.…”

Section: Tfs Searching and Clustering Of Expression Pro Lesmentioning

confidence: 99%

Brief description of the molecular aspects of Paralithodes camtschaticus larval development

Boyko,

Dolmatov,

Girich

et al. 2024

Preprint

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The transcriptome of the red king crab Paralithodes camtschaticus was sequenced at four developmental stages—zoea I, zoea IV, glaucothoe, juvenile—on an Illumina sequencer. Based on our RNA-seq data and the paired-end reads from 112 libraries obtained by other researchers earlier, we have achieved the currently most complete transcriptome assembly for P. camtschaticus with the best basic statistical parameters. The analysis of enrichment processes at different stages showed, that in the early larvae adaptation to elevated temperature and hypoxia do not function. Thus, it is important to maintain optimal condition for the normal larval development and reducing mortality. As results of expression profiles clustering and transcription factor searching, we found that most of them are associated with the development of various organs, metamorphosis, and immune respone. The data obtained by us provide an additional basis for a deeper study of the mechanisms of the biphasic life cycle in decapods and can be used in commercial Kamchatka crab breeding programs.

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Section: Tfs Searching and Clustering Of Expression Pro Lesmentioning

confidence: 99%

Brief description of the molecular aspects of Paralithodes camtschaticus larval development

Boyko,

Dolmatov,

Girich

et al. 2024

Preprint

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“…Although research to reveal the development and function of LNs has just begun, the contribution of LNs to PN dendrites targeting has been recently suggested (Melnattur et al, 2013). In the Dichaete mutant brain, PN dendrites target different or ectopic glomeruli.…”

Section: Ln Influences On Pn Dendrite Targetingmentioning

confidence: 99%

Development of olfactory projection neuron dendrites that contribute to wiring specificity of the Drosophila olfactory circuit

et al. 2014

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The antennal lobe (AL) of Drosophila is the first olfactory processing center in which olfactory input and output are spatially organized into distinct channels via glomeruli to form a discrete neural map. In each glomerulus, the axons of a single type of olfactory receptor neurons (ORNs) synapse with the dendrites of a single type of projection neurons (PNs). The AL is an ideal place to study how the wiring specificity between specific types of ORNs and PNs is established during development. During the past two decades, the involvement of diverse molecules in the specification and patterning of ORNs and PNs has been reported. Furthermore, local interneurons-another component of glomeruli-have been recently catalogued and their functions have been gradually dissected. Although there is accumulating knowledge about the involvement of these three cell types in the wiring specificity of the olfactory system, in this review, we focus especially on the development of PN dendrites.

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“…Dichaete functions in the development of the CNS by regulating numerous genes ( 141 – 143 ). In the adult fly brain, dichaete is expressed in glia and neurons of the olfactory circuit but there is no data on memory formation at this time ( 144 ).…”

Section: Introductionmentioning

confidence: 99%

From Learning to Memory: What Flies Can Tell Us about Intellectual Disability Treatment

2015

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Intellectual disability (ID), previously known as mental retardation, affects 3% of the population and remains without pharmacological treatment. ID is characterized by impaired general mental abilities associated with defects in adaptive function in which onset occurs before 18 years of age. Genetic factors are increasing and being recognized as the causes of severe ID due to increased use of genome-wide screening tools. Unfortunately drug discovery for treatment of ID has not followed the same pace as gene discovery, leaving clinicians, patients, and families without the ability to ameliorate symptoms. Despite this, several model organisms have proven valuable in developing and screening candidate drugs. One such model organism is the fruit fly Drosophila. First, we review the current understanding of memory in human and its model in Drosophila. Second, we describe key signaling pathways involved in ID and memory such as the cyclic adenosine 3′,5′-monophosphate (cAMP)–cAMP response element binding protein (CREB) pathway, the regulation of protein synthesis, the role of receptors and anchoring proteins, the role of neuronal proliferation, and finally the role of neurotransmitters. Third, we characterize the types of memory defects found in patients with ID. Finally, we discuss how important insights gained from Drosophila learning and memory could be translated in clinical research to lead to better treatment development.

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The sox gene Dichaete is expressed in local interneurons and functions in development of the Drosophila adult olfactory circuit

Cited by 3 publications

References 62 publications

Brief description of the molecular aspects of Paralithodes camtschaticus larval development

Brief description of the molecular aspects of Paralithodes camtschaticus larval development

Development of olfactory projection neuron dendrites that contribute to wiring specificity of the <i>Drosophila</i> olfactory circuit

From Learning to Memory: What Flies Can Tell Us about Intellectual Disability Treatment

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