The spatial and temporal trends of severe periodontitis burden in Asia, 1990–2019: A population‐based epidemiological study

Abstract

Background To investigate the long‐term and spatial patterns of incidence, prevalence, and disability‐adjusted life year (DALY) rates of severe periodontitis in Asia from 1990 to 2019, and to estimate the associations between disease burden and socioeconomic development using the Socio‐Demographic Index (SDI). Methods Data were obtained from the global burden of disease study 2019. The average annual percent change (AAPC) was calculated to reflect temporal trends, spatial autocorrelation analysis was conducted to estimate the spatial characteristics, and spatial panel models were used to investigate the association between SDI and severe periodontitis burden. Results For Asia as a whole, the crude rates increased by 1.10% per year for incidence, 1.42% per year for prevalence, and 1.41% per year for DALY from 1990 to 2019. The age‐standardized incidence, prevalence and DALY rates increased by 0.18%, 0.22%, and 0.23% per year, respectively. Spatially, the hot spots of age‐standardized incidence, prevalence and DALY rates were located in Southern Asia, besides, these rates all showed increasing trends in most countries, and the increases were clustered in Southeastern Asia. Further, SDI showed a negative association with incidence (coef = −14.44; 95% CI: −24.63, −4.25) and prevalence (coef = −40.09; −51.81, −28.36), and a positive association with DALY rates (coef = 0.31; 0.23; 0.38). Conclusions Severe periodontitis poses a serious public health challenge in Asian countries with increasing temporal trends and substantial spatial inequalities. Effective geographically targeted public health interventions and strategies are needed to address the growing burden associated with severe periodontitis.

E7-Conjugated Bio-Inspired Microspheres as a Biological Barrier for Guided Tissue Regeneration

“…Similar to the NFG-MS, the E7-NFG-MS consisted entirely of nanofibers with an average diameter of 230 ± 42 nm (Figure 2A), which is in the same range as that of natural collagen fibers in bone ECM. The E7-NFG-MS had a high porosity of 93.2 ± 0.1% and a low apparent density of 0.092 ± 0.001 g/ cm 3 , which provides sufficient space for ECM deposition and nutrient exchange and minimizes the generation of degradation byproducts when the microspheres are used as injectable scaffolds (Figure 2B,C). The degradation rate of E7-NFG-MS was slightly slower than that of NFG-MS, possibly owing to the E7 peptide covering the enzymatic degradation sites on the surfaces of the microspheres (Figure 2D).…”

“…Severe periodontitis is the sixth most prevalent disease worldwide, affecting more than one billion people worldwide . Moreover, the prevalence of periodontitis is expected to increase as the population ages, presenting a significant public health challenge . Periodontitis is commonly treated through conventional therapies (e.g., scaling and root planning, antibiotics, and flap surgery) to remove local pathogenic factors like plaque and tartar, eliminate inflammation, and ultimately alleviate or halt the progression of the disease .…”

“… 2 Moreover, the prevalence of periodontitis is expected to increase as the population ages, presenting a significant public health challenge. 3 Periodontitis is commonly treated through conventional therapies (e.g., scaling and root planning, antibiotics, and flap surgery) to remove local pathogenic factors like plaque and tartar, eliminate inflammation, and ultimately alleviate or halt the progression of the disease. 4 Although these therapies can be effective, they do not address the problem of periodontal tissue loss, and the function of the periodontium remains compromised, which undermines the long-term efficacy of the treatments.…”

Nanochemistry of gold: from surface engineering to dental healthcare applications

“…2 In Asia, severe periodontitis saw a steady annual increase in incidence, prevalence, and disability-adjusted life years from 1990 to 2019, emerging as a primary contributor to adult tooth loss. 3 Periodontal tissue is critical in defending against oral cavity microorganisms and maintaining chewing function. Moreover, periodontal disease and oral pathogens have intricate connections to various health concerns, including cancer, diabetes, cardiovascular diseases, adverse pregnancy outcomes, and Alzheimer's disease (AD).…”

Association between Periodontitis and HbA1c Levels in Non-Diabetic Patients: A Systematic Review and Meta-Analysis

“…Additionally, it is the most common cause of natural tooth loss in adults [2]. The prevalence of periodontitis is nearly 50% among adults worldwide, and this proportion is even higher (70%) among those over 65 years of age, which is a cause of concern in terms of global health and the economic burden [3][4][5]. Furthermore, periodontitis can elevate systemic inflammatory pressure and impact systemic health [6][7][8][9].…”