The Spatial Distribution of Pulvinar Neurons That Project to Two Subregions of the Inferior Parietal Lobule in the Macaque

Hardy, Sandro; Lynch, James C.

doi:10.1093/cercor/2.3.217

Cited by 64 publications

(49 citation statements)

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“…Similarly, a dorsal portion of the lateral pulvinar projects to LIP Hardy and Lynch, 1992;Baizer et al, 1993). Our results suggest that neurons in the lateral pulvinar mediate a projection from the superficial layers of the superior colliculus to LIP.…”

Section: Superior Colliculus To Lipsupporting

confidence: 53%

“…Injections of HSV1 into IPL led to dense labeling in thalamic nuclei known to be the origin of input to each cortical region (Kasdon and Jacobson, 1978;Asanuma et al, 1985;Schmahmann and Pandya, 1990;Hardy and Lynch, 1992;Baizer et al, 1993). Labeled neurons were found in other thalamic nuclei as well.…”

Section: Thalamic Labelingmentioning

confidence: 95%

“…Thalamic inputs to LIP, area 7a, and area 7b are known to be distinct Schmahmann and Pandya, 1990;Hardy and Lynch, 1992). Such segregation of the thalamic projections suggests that the subdivisions of IPL receive unique patterns of subcortical inputs as well.…”

Section: Abstract: Posterior Parietal Cortex; Lip; Area 7a; Area 7b;mentioning

confidence: 99%

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The Inferior Parietal Lobule Is the Target of Output from the Superior Colliculus, Hippocampus, and Cerebellum

et al. 2001

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The inferior parietal lobule (IPL) is a functionally and anatomically heterogeneous region that is concerned with multiple aspects of sensory processing and sensorimotor integration. Although considerable information is available about the corticocortical connections to the IPL, much less is known about the origin and importance of subcortical inputs to this cortical region. To examine this issue, we used retrograde transneuronal transport of the McIntyre-B strain of herpes simplex virus type 1 (HSV1) to identify the second-order neurons in subcortical nuclei that project to the IPL. Four monkeys (Cebus apella) received injections of HSV1 into three different subregions of the IPL. Injections into a portion of the lateral intraparietal area labeled second-order neurons primarily in the superficial (visual) layers of the superior colliculus. Injections of HSV1 into a portion of area 7a labeled many second-order neurons in the CA1 region of the hippocampus. In contrast, virus injections within a portion of area 7b labeled second-order neurons in posterior regions of the dentate nucleus of the cerebellum. These observations have some important functional implications. The IPL is known to be involved in oculomotor and attentional mechanisms, the establishment of maps of extrapersonal space, and the adaptive recalibration of eye-hand coordination. Our findings suggest that these functions are subserved by distinct subcortical systems from the superior colliculus, hippocampus, and cerebellum. Furthermore, the finding that each system appears to target a separate subregion of the IPL provides an anatomical substrate for understanding the functional heterogeneity of the IPL.

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Section: Superior Colliculus To Lipsupporting

confidence: 53%

Section: Thalamic Labelingmentioning

confidence: 95%

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The Inferior Parietal Lobule Is the Target of Output from the Superior Colliculus, Hippocampus, and Cerebellum

et al. 2001

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“…Approximately 0.6 l of each fluorescent dye was placed at each injection site. All tracers were pressure-injected (Hardy and Lynch, 1992), using a 1 or 5 l Hamilton syringe. Each injection was made over a 5 min period.…”

Section: Methodsmentioning

confidence: 99%

Subcortical Input to the Smooth and Saccadic Eye Movement Subregions of the Frontal Eye Field inCebusMonkey

Tian¹,

Lynch

1997

J. Neurosci.

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We have recently identified two functional subregions in the frontal eye field (FEF) of the Cebus monkey, a smooth eye movement subregion (FEFsem) and a saccadic subregion (FEFsac). The thalamic input to these two subregions was studied and quantified to gain more information about the influence of the cerebellum and basal ganglia on the oculomotor control mechanisms of the cerebral cortex. A recent study using transneuronal transport of virus demonstrated that there are neurons in the basal ganglia and cerebellum that project to the FEFsac with only a single intervening synapse (Lynch et al., 1994). In the present study, we concentrated on the thalamic input to the FEFsem to define possible basal ganglia-thalamuscortex and cerebellum-thalamus-cortex channels of information flow to the FEFsem. We localized the functional subregions using low threshold microstimulation, and retrogradely transported fluorescent tracers were then placed into the FEFsem and FEFsac.The neurons that project to the FEFsem are distributed in (1) the rostral portion of the ventral lateral nucleus, pars caudalis, (2) the caudal portion of the ventral lateral nucleus, pars caudalis, (3) the mediodorsal nucleus, (4) the ventral anterior nucleus, pars parvocellularis, and (5) the ventral anterior nucleus, pars magnocellularis. In contrast, the large majority of neurons that project to the FEFsac are located in the paralaminar region of the mediodorsal nucleus. The FEFsac and FEFsem thus each receive neural input from both basal ganglia-receiving and cerebellar-receiving cell groups in the thalamus, but each receives input from a unique combination of thalamic nuclei.

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“…Comparison across studies suggests that the lateral PM is more strongly related to visual processing, by virtue of its connections with posterior parietal and inferior temporal cortex (DeVito and Simmons, 1976;Mauguiere, 1985, 1987;Schmamann and Pandya, 1990;Baleydier and Morel, 1992;Hardy and Lynch, 1992;Cusick et al, 1993;Morecraft et al, 1993;Webster et al, 1993;Romanski et al, 1997), whereas the medial PM is more strongly related to auditory processing, based on preferential connections with auditory areas of the superior temporal region established in the present study and several others (Simpson, 1952;Locke, 1960;DeVito and Simmons, 1976;Trojanowski and Jacobson, 1976;Burton and Jones, 1976;Mauguiere and Baleydier, 1978;Streitfeld, 1980;Markowitsch et al, 1985;Moran et al, 1987;Pandya et al, 1994;Romanski et al, 1997). Most of the studies cited above, among others (Jones and Powell, 1970b;Trojanowski and Jacobson, 1976;Divac et al, 1977;Asanuma et al, 1985;Pandya, 1985, 1989;, have shown that the central PM has connections with auditory, somatic, visual, and multimodal cortical areas, suggesting that the central PM may subserve multimodal integrative functions more than the lateral or medial portions of the nucleus, which appear to be somewhat more modality specific.…”

Section: Medial Pulvinarmentioning

confidence: 99%

Thalamocortical connections of the parabelt auditory cortex in macaque monkeys

1998

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The auditory cortex of macaque monkeys contains a core of primary-like areas surrounded by a narrow belt of associated fields that encompass much of the superior temporal plane in these animals. Adjacent to the lateral belt on the superior temporal gyrus is a parabelt region that contains at least two subdivisions (rostral and caudal). In a previous study (Hackett et al. [1998] J. Comp. Neurol. 394:475-495), we determined that the parabelt has topographic connections with the belt areas surrounding the core, but minimal connections with the core itself. In this study, we describe the thalamocortical connections of the parabelt auditory cortex based on multiple injections of neuronal tracers into this region in each of five macaque monkeys. Injections confined to the parabelt labeled large numbers of neurons in the dorsal (MGd) and magnocellular (MGm) divisions of the medial geniculate complex (MGC), suprageniculate (Sg), limitans (Lim), and medial pulvinar (PM) nuclei. Only when injections encroached on the lateral belt cortex were substantial numbers of labeled neurons found in the ventral (MGv) division of the MGC, consistent with the absence of significant connections between the parabelt and core fields. The rostrocaudal topography of the parabelt region was maintained in the thalamocortical connections, supporting the parcellation of this region of cortex. The results suggest that the parabelt region represents a third level of auditory cortical processing, which is not influenced by direct inputs from primary cortical or subcortical auditory structures.

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The Spatial Distribution of Pulvinar Neurons That Project to Two Subregions of the Inferior Parietal Lobule in the Macaque

Cited by 64 publications

References 0 publications

The Inferior Parietal Lobule Is the Target of Output from the Superior Colliculus, Hippocampus, and Cerebellum

The Inferior Parietal Lobule Is the Target of Output from the Superior Colliculus, Hippocampus, and Cerebellum

Subcortical Input to the Smooth and Saccadic Eye Movement Subregions of the Frontal Eye Field inCebusMonkey

Thalamocortical connections of the parabelt auditory cortex in macaque monkeys

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