With the rapid development of urbanization, the blind expansion of urban space has led to a series of social problems. In this process, the degree of urban function mixing affects the urbanization development level, making it particularly important to study the degree of coupling coordination between the two aspects. In this paper, taking Beijing as an example, we use urban point of interest (POI) data and taxi GPS trajectory data to calculate the urban POIs’ spatial entropy and taxis’ temporal entropy, based on the information entropy. We use the POIs’ spatial entropy and taxis’ temporal entropy to measure the urban function mixing degree. Also, the model of coupling coordination degree is used to measure the degree of coupling coordination between the urban function mixing degree and the urbanization development level. The results indicate the following: First, the POIs’ spatial entropy and taxis’ temporal entropy have significant regional imbalances. On the whole, both show a declining pattern when moving from the central urban area to the outer suburbs. The urban function mixing degree and urbanization development level are also higher in the central urban area than in the outer suburbs. Second, the coupling coordination among the urbanization development level, POIs’ spatial entropy, and taxis’ temporal entropy is distributed unevenly across various regions, which means that the three types of coupling coordination are in balanced development in the central urban area, but in unbalanced development in the outer suburbs. Third, from the perspective of spatial correlation characteristics, the higher is the degree of spatial agglomeration, the higher are the urban function mixing degree and urbanization development level, and the higher is the coupling coordination degree among the urbanization development level, POIs’ spatial entropy, and taxis’ temporal entropy. Therefore, relevant departments should plan the construction of urban functional areas reasonably, according to the degree of coupling coordination between the urban function mixing degree and the urbanization development level in different regions, so as to realize the healthy and sustainable development of a city.