The speciation of vanadium in human serum

Jakusch, Tamás; Pessoa, João Costa; Kiss, Tamás

doi:10.1016/j.ccr.2011.02.022

Cited by 104 publications

(100 citation statements)

References 67 publications

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“…11,[18][19][20] Several vanadium complexes have been found to have higher insulin enhancing activities than inorganic oxovanadium(V) or oxovanadium(IV) salts, but probably this improved efficacy probably relates to the increased bioavailability of the metal ion when involved in a complex rather than to increased potency at the phosphatase enzyme active sites. [19][20][21][22][23] Among the several complexes exhibiting insulin enhancing properties, V IV O(maltolato) 2 (BMOV) and V IV O(ethylmaltolato) 2 (BEOV) have been extensively studied from the chemical and pharmacological points of view. 8,[21][22][23][24][25][26] Complexes with 3-hydroxy-4-pyrones (3,4-HP) have also been extensively studied.…”

Section: Introductionmentioning

confidence: 99%

“…[19][20][21][22][23] Among the several complexes exhibiting insulin enhancing properties, V IV O(maltolato) 2 (BMOV) and V IV O(ethylmaltolato) 2 (BEOV) have been extensively studied from the chemical and pharmacological points of view. 8,[21][22][23][24][25][26] Complexes with 3-hydroxy-4-pyrones (3,4-HP) have also been extensively studied. 19,[24][25][26][27][28][29] Replacement of the O atom of the pyrone ring by a N or N-R group yields pyridinone derivatives, and both families of compounds maintain the (O − , O − ) binding set, forming quite stable complexes with many metal ions.…”

Section: Introductionmentioning

confidence: 99%

“…22,23,40,[43][44][45][46][47][48][49][50] Transferrin (hTF) is a single-chain glycoprotein containing around 630 amino acids which are arranged in two similar lobes, and is important for iron transportation. It is present in human blood plasma in about 37 μM concentration.…”

Section: Introductionmentioning

confidence: 99%

“…In fact hTF can bind strongly to a range of other metal ions, as is the case of V IV O 2+ . 23,43,[48][49][50] Human serum albumin (HSA) is a globular protein consisting of a single polypeptide chain of 585 amino acids. It is the most abundant protein in plasma, accounting for ∼60% of total plasma protein, with a concentration of ca.…”

Section: Introductionmentioning

confidence: 99%

“…Strong evidence has been provided to support that most of the vanadium in the serum is bound to hTF, even in the absence of HCO 3 − . 22,23,40,43,[48][49][50][51][52][53][54][55][56][57] The results indicate that two vanadium ions are bound to the metal-ion-free apo-hTF, at the usual specific Fe III binding sites. Under the physiological conditions, particularly in the hypothetical situation where the vanadium concentration is higher than ca.…”

Section: Introductionmentioning

confidence: 99%

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A novel VIVO–pyrimidinone complex: synthesis, solution speciation and human serum protein binding

Gonçalves¹,

Tomaz

Correia³

et al. 2013

Dalton Trans.

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The pyrimidinones mhcpe, 2-methyl-3H-5-hydroxy-6-carboxy-4-pyrimidinone ethyl ester (mhcpe, 1), 2,3-dimethyl-5-benzyloxy-6-carboxy-4-pyrimidinone ethyl ester (dbcpe, 2) and N-methyl-2,3-dimethyl-5-hydroxy-6-carboxyamido-4-pyrimidinone (N-MeHOPY, 3), are synthesized and their structures determined by single crystal X-ray diffraction. The acid-base properties of 1 are studied by potentiometric and spectrophotometric methods, the pK a values being 1.14 and 6.35. DFT calculations were carried out to determine the most stable structure for each of the H 2 L + , HL and L − forms (HL = mhcpe) and assign the groups involved in the protonation-deprotonation processes. The mhcpe − ligand forms stable complexes with V IV O 2+ in the pH range 2 to 10, and potentiometry, EPR and UV-Vis techniques are used to identify and characterize the V IV O-mhcpe species formed. The results are consistent with the formation of V IV O,

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A novel VIVO–pyrimidinone complex: synthesis, solution speciation and human serum protein binding

Gonçalves¹,

Tomaz

Correia³

et al. 2013

Dalton Trans.

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Interaction of [V^IVO(acac)₂] with Human Serum Transferrin and Albumin

Correia

Chorna

Cavaco

et al. 2017

Chemistry An Asian Journal

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[VO(acac) ] is a remarkable vanadium compound and has potential as a therapeutic drug. It is important to clarify how it is transported in blood, but the reports addressing its binding to serum proteins have been contradictory. We use several spectroscopic and mass spectrometric techniques (ESI and MALDI-TOF), small-angle X-ray scattering and size exclusion chromatography (SEC) to characterize solutions containing [VO(acac) ] and either human serum apotransferrin (apoHTF) or albumin (HSA). DFT and modeling protein calculations are carried out to disclose the type of binding to apoHTF. The measured circular dichroism spectra, SEC and MALDI-TOF data clearly prove that at least two VO-acac moieties may bind to apoHTF, most probably forming [V O(acac)(apoHTF)] complexes with residues of the HTF binding sites. No indication of binding of [VO(acac) ] to HSA is obtained. We conclude that V O-acac species may be transported in blood by transferrin. At very low complex concentrations speciation calculations suggest that [(VO)(apoHTF)] species form.

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Correlation of Insulin‐Enhancing Properties of Vanadium‐Dipicolinate Complexes in Model Membrane Systems: Phospholipid Langmuir Monolayers and AOT Reverse Micelles

Sostarecz

Gaidamauskas

Distin

et al. 2014

Chemistry A European J

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We explore the interactions of V(III) -, V(IV) -, and V(V) -2,6-pyridinedicarboxylic acid (dipic) complexes with model membrane systems and whether these interactions correlate with the blood-glucose-lowering effects of these compounds on STZ-induced diabetic rats. Two model systems, dipalmitoylphosphatidylcholine (DPPC) Langmuir monolayers and AOT (sodium bis(2-ethylhexyl)sulfosuccinate) reverse micelles present controlled environments for the systematic study of these vanadium complexes interacting with self-assembled lipids. Results from the Langmuir monolayer studies show that vanadium complexes in all three oxidation states interact with the DPPC monolayer; the V(III) -phospholipid interactions result in a slight decrease in DPPC molecular area, whereas V(IV) and V(V) -phospholipid interactions appear to increase the DPPC molecular area, an observation consistent with penetration into the interface of this complex. Investigations also examined the interactions of V(III) - and V(IV) -dipic complexes with polar interfaces in AOT reverse micelles. Electron paramagnetic resonance spectroscopic studies of V(IV) complexes in reverse micelles indicate that the neutral and smaller 1:1 V(IV) -dipic complex penetrates the interface, whereas the larger 1:2 V(IV) complex does not. UV/Vis spectroscopy studies of the anionic V(III) -dipic complex show only minor interactions. These results are in contrast to behavior of the V(V) -dipic complex, [VO2 (dipic)](-) , which penetrates the AOT/isooctane reverse micellar interface. These model membrane studies indicate that V(III) -, V(IV) -, and V(V) -dipic complexes interact with and penetrate the lipid interfaces differently, an effect that agrees with the compounds' efficacy at lowering elevated blood glucose levels in diabetic rats.

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The speciation of vanadium in human serum

Cited by 104 publications

References 67 publications

A novel VIVO–pyrimidinone complex: synthesis, solution speciation and human serum protein binding

A novel VIVO–pyrimidinone complex: synthesis, solution speciation and human serum protein binding

Interaction of [V^IVO(acac)₂] with Human Serum Transferrin and Albumin

Correlation of Insulin‐Enhancing Properties of Vanadium‐Dipicolinate Complexes in Model Membrane Systems: Phospholipid Langmuir Monolayers and AOT Reverse Micelles

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The speciation of vanadium in human serum

Cited by 104 publications

References 67 publications

A novel VIVO–pyrimidinone complex: synthesis, solution speciation and human serum protein binding

A novel VIVO–pyrimidinone complex: synthesis, solution speciation and human serum protein binding

Interaction of [VIVO(acac)2] with Human Serum Transferrin and Albumin

Correlation of Insulin‐Enhancing Properties of Vanadium‐Dipicolinate Complexes in Model Membrane Systems: Phospholipid Langmuir Monolayers and AOT Reverse Micelles

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Interaction of [V^IVO(acac)₂] with Human Serum Transferrin and Albumin