The Specific Feature of Cytokines Regulation by Pathology of Thyroid Disease (Review)

A, Gryaznova M; Khamnueva, L. Yu.

doi:10.26787/nydha-2226-7425-2017-19-7-33-39

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…It should be noted that the authors of some studies indicate a decrease of the production of TNF-α at diffuse toxic goiter or production close to normal (Saprina et al 2012). At the same time, Gryaznova and Khamnueva (2017) have noted a pronounced hypercytokinemia in patients with a hypothyroidism in a setting of autoimmune thyroiditis. Treatment for 4-6 months had virtually no effect on cytokine levels, despite the normalization of TSH and fT4 levels as well as the relief of clinical manifestations.…”

Section: Discussionmentioning

confidence: 97%

Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?

Shcherba

Krynytska

Корда

2021

Endocrine Regulations

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Objective. The aim of the present study was to investigate the presence of inflammatory mediators in rats with only periodontitis and periodontitis in a setting of hyper- and hypo-thyroidism and to analyze the correlative linkages between inflammatory mediators and thyroid hormones. Methods. White male 12–14 weeks old inbred rats (n=48) weighing 180–200 g were employed in the experiment. They were randomly divided into the following groups: Group I – control group, Group II – group with a model of periodontitis, Group III – group with a periodontitis in a setting of hyperthyroidism, and Group IV – group with periodontitis in a setting of hypothyroidism. The presence of tumor-necrosis factor-α (TNF-α) and interleukins IL-1β and IL-10 in the periodontal homogenate supernatant was studied by a solid-phase enzyme-linked immunosorbent assay. Results. It was shown that experimental lipopolysaccharide (LPS)-induced periodontitis is accompanied by hyperproduction of pro-inflammatory cytokines (TNF-α, IL-1β) and reduction of anti-inflammatory cytokines (IL-10), whereas TNF-α underwent to maximum changes. Thyroid dysfunction exacerbates cytokine imbalance and severity of inflammation in experimental LPS-induced periodontitis, especially pronounced at hyperthyroidism, as evidenced by the predominance of TNF-α and IL-1β levels in the periodontal homogenate supernatant by 38.5% (р<0.01) and 75.6% (p<0.001), respectively, hyperthyroid over the euthyroid, and by 20.1% (p<0.05) and 24.1% (p<0.05), respectively, over the hypothyroid rats. Conclusions. Thyroid dysfunction, especially hyperthyroidism, may play an important role in the pro-inflammatory response in periodontitis. Hyperproduction of inflammatory mediators in thyroid dysfunction can induce a noticeable damage in the whole apparatus of the periodontium, thereby causing progression of periodontitis.

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Section: Discussionmentioning

confidence: 97%

Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?

Shcherba

Krynytska

Корда

2021

Endocrine Regulations

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Influence of hypoxic therapy on the content of individual cytokines in women with autoimmune thyroiditis

Ignatenko,

Maylyan,

Lesnichenko

et al. 2023

Kazan Med J

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Background. The high prevalence of autoimmune thyroiditis and the insufficient effectiveness of hormone replacement therapy dictate the need to explore alternative methods of treating the disease. These methods include interval hypoxic therapy, but its effect on the cytokine profile in autoimmune thyroiditis has not been studied enough. Aim. To study the effect of interval hypoxic therapy in combination with hormone replacement therapy on cytokine status in autoimmune thyroiditis and hypothyroidism. Material and methods. 136 women with primary diagnosed autoimmune thyroiditis and hypothyroidism were examined. Half of them (n=68) received only hormone replacement therapy for 12 months. The rest of the women (n=68), along with sodium levothyroxine, underwent sessions of interval hypoxic therapy (every 3 months for 10 days according to the formula 555). The concentrations of interleukins-4, -6, -8, -10 and tumor necrosis factor in blood serum were determined. To compare the results in groups, KruskalWallis rank univariate analysis and Dunn's test were used. The Wilcoxon t-test was used to compare two related samples. Results. Both isolated hormone therapy and its combination with hypoxic therapy did not affect the concentrations of interleukins-4, -8, -10 and tumor necrosis factor in the blood serum of women with initially diagnosed autoimmune thyroiditis and hypothyroidism. However, hypoxic therapy caused a decrease (p=0.0001) in the initially elevated concentration of interleukin-6 to the level of the control group, which did not happen with the isolated intake of levothyroxine sodium. Conclusion. The combination of sodium levothyroxine with hypoxic therapy causes a decrease in the level of interleukin-6, which is elevated in women with newly diagnosed autoimmune thyroiditis and hypothyroidism.

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Cytokines and Thyroid Markers in Blood Serum in Women With Autoimmune Thyroiditis in the Course of Treatment

Ignatenko

Maylyan

Kapanadze³

2022

Crimea Journal of Experimental and Clinical Medicine

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The study involved 147 women aged 31-47 with newly diagnosed AIT and hypothyroidism in the dynamics of replacement therapy with levothyroxine (before and after 6 months). The control group consisted of 63 conditionally healthy women, examined once at the beginning of the study. In peripheral blood serum, the concentrations of TNF-α, IL-1β, IL-4, IL-6, IL-8, IL-10, IL-17A, RANKL, OPG, TSH and TPOAb were determined. It was found that the initially increased values (p<0,001) of IL-1β and IL-6 remained in patients after substitu- tion therapy at higher levels than in the control group (p<0,001). The tendency to an increase in the levels of IL-10 (p=0,056) and IL-17A (p=0,067) revealed at the beginning of therapy was leveled out (p>0,05) by the end of the ob- servation. TNF-α values did not significantly differ from those of the control group both at baseline and after 6 months (p=0,166 and p=0,184, respectively). The concentrations of IL-4 (p=0,376 and p=0,179, respectively), IL-8 (p=0,102 and p=0,116, respectively) and OPG (p=0,988 and p=0,661, respectively) remained at the level of the results of healthy women before and after treatment. RANKL concentrations before treatment were elevated (p=0,029), having lost their significant significance after therapy (p=0,096). The initially decreased values of the OPG/RANKL index (p=0,017) also did not differ on repeated examination from the indicators of the control group (p=0,253). After 6 months of taking levo- thyroxine in women with AIT, a significant (p<0,001) decrease in initially elevated TSH levels to the values characteris- tic of the control group was recorded against the background of a significant (p<0,001) increase in the concentrations of initially elevated autoimmune antibodies (p<0,001). When examining women with AIT and confirmed hypothyroidism, it was found that replacement therapy with levothyroxine for 6 months did not significantly affect the production of most of the studied cytokines against the back- ground of a decrease in the initially increased TSH values to the values of the control group and a significant increase in the initially increased TPOAb.

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The Specific Feature of Cytokines Regulation by Pathology of Thyroid Disease (Review)

Cited by 5 publications

References 13 publications

Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?

Does thyroid dysfunction influence inflammatory mediators in experimental periodontitis?

Influence of hypoxic therapy on the content of individual cytokines in women with autoimmune thyroiditis

Cytokines and Thyroid Markers in Blood Serum in Women With Autoimmune Thyroiditis in the Course of Treatment

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