The Specific Gravity of the Urine as a Test of Kidney Function

Lashmet, F. H.

doi:10.1001/jama.1930.02710500001001

Cited by 7 publications

(3 citation statements)

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“…The concentration test of Lashmet and Newburgh (1930) 2 The subject remains in bed four days, during the first three of which he is on a special diet. The diet consists of 45 grams of protein, 106 grams of fat, and 180 grams of carbohydrate.…”

Section: Concentration Testsmentioning

confidence: 99%

“…We did this by means of small weighing bottles as described by Moore and Van Slyke (1930). When protein was present in significant amounts the observed specific gravity was corrected by subtraction of the increment in gravity due to the protein, as was done by Lashmet and Newburgh (1930).3 Their more recent (1932) correction curve corresponds to the equation: Sp. Gr.…”

Section: Concentration Testsmentioning

confidence: 99%

“…Two forms of the concentration test (Addis and Shevky (1922); Lashmet and Newburgh (1930)) and one of the combined concentration and dilution test (Lundsgaard (1920)) have been used in this clinic for comparison with the blood urea clearance. In addition to our results with these tests we have charted the data of Ong (1932) and of Bruger and Mosenthal (1932).…”

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confidence: 99%

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The Significance of Concentration and Dilution Tests in Bright's Disease

Alving¹,

Slyke²

1934

J. Clin. Invest.

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The first quantitative evidence that nephritis diminishes the ability to excrete urine of either high concentration or high dilution was apparently furnished by Koranyi (1899) and his collaborators, K6vesi and RothSchulz (1900), by means of the freezing point method. Regular application to studies of renal function, however, appears to have first begun in Volhard's (1918) clinic, where the " concentration and dilution " test has been in use since about 1908. In this test the renal function is estimated from the ability to excrete a urine of large volume and low specific gravity after drinking 1.5 liter of water (dilution test), and urine of high specific gravity after a subsequent period in which no fluid is drunk (concentration test). Modifications of these tests or their combination have been made by various authors. They have been reviewed by Pratt (1926) (with his own observations on 58 patients), by Mosenthal (1930), by Lashmet and Newburgh (1930), and with especial completeness by Volhard and Becher (1929). The simplicity of these tests, and their consequent wide application, render it desirable to define as exactly as possible the meaning of their results.In order to obtain information for this purpose we have made graphic statistical comparisons of results of concentration tests with results of the urea clearance test, the clinical significance of which has previously been established (Van Slyke, Stillman, M6ller, et al. (1930) (1930)) and one of the combined concentration and dilution test (Lundsgaard (1920)) have been used in this clinic for comparison with the blood urea clearance. In addition to our results with these tests we have charted the data of Ong (1932) and of Bruger and Mosenthal (1932). The different concentration and dilution tests, as used by the writers and the above authors, were applied as follows. Concentration testsThe concentration test of Addis and Shevky (1922). The subject abstains from fluids of all sorts from after breakfast on one day until he rises from bed on the morning of the following day. During the last 12 hours of the dry period (from 8 p.m. to 8 a.m.) the urine is collected, and the specific gravity of this specimen is measured. The Addis-Shevky test prescribes no preparatory period on a special diet.In applying this method to albuminous urines we have subtracted from the observed specific gravity a correction for the effect of the protein, in the manner described below for the Lashmet-Newburgh test. The gravities given in our charts are the corrected values. The urinometer used has been found accurate to within 0.001.Addis and Shevky have found that in normal individuals, previously on ordinary diets, the average specific gravity of urine obtained as above described was 1.032, that 95 per cent of normal subjects on ordinary diets showed values of 1.028 or above, and 100 per cent above 1.026.The concentration test of Lashmet and Newburgh (1930) 2 The subject remains in bed four days, during the first three of which he is on a special diet. The diet consists of 45 g...

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Section: Concentration Testsmentioning

confidence: 99%

Section: Concentration Testsmentioning

confidence: 99%