The specificity of immune priming in silkworm, Bombyx mori, is mediated by the phagocytic ability of granular cells

Wu, Gongqing; Li, Mei; Liu, Yi; Ding, Ying; Yi, Yunhong

doi:10.1016/j.jinsphys.2015.07.004

Cited by 47 publications

(30 citation statements)

References 45 publications

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“…In invertebrates, the activation of a subset of hemocyte immune cells was expected to be the main support of innate immune memory. Following infection by a virus, a bacteria or a protozoa, insects are able to select and activate a competent subpopulation of cells with enhance capacities of lysis or phagocytosis . Hemocytes in Drosophila acquire their function through multistep events of differentiation, which involve the regulatory interaction of evolutionarily conserved transcription and epigenetic factors .…”

Section: Toward a Unifying Model For Innate Immune Memorymentioning

confidence: 99%

Innate immune memory: An evolutionary perspective

Gourbal

Pinaud

Beckers

et al. 2018

Immunological Reviews

203

157

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Over the last decades, there was increasing evidence for the presence of innate immune memory in living organisms. In this review, we compare the innate immune memory of various organisms with a focus on phylogenetics. We discuss the acquisition and molecular basis of immune memory and we describe the innate immune memory paradigm and its role in host defense during evolution. The molecular characterization of innate immunological memory in diverse organisms and host-parasite systems reconciles mechanisms with phenomena and paves the way to molecular comprehension of innate immune memory. We also revise the traditional classification of innate and adaptive immunity in jawed vertebrates. We emphasize that innate immune responses have the capacity to be "primed" or "trained", thereby exerting a yet unknown type of immunological memory upon re-infection.

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Section: Toward a Unifying Model For Innate Immune Memorymentioning

confidence: 99%

Innate immune memory: An evolutionary perspective

Gourbal

Pinaud

Beckers

et al. 2018

Immunological Reviews

203

157

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show abstract

“…Immune priming allows invertebrates to show improved survival to a pathogen following a first infection. This mechanism is now known in several insect species [30][31][32] and the freshwater snail Biomphalaria glabrata [20,33]. In the marine realm, immune priming was first examined in copepods [34].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Immune priming and portal of entry effectors improve response to vibrio infection in a resistant population of the European abalone

Dubief

Nunes

Basuyaux³

et al. 2017

Fish & Shellfish Immunology

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Since 1997, populations of the European abalone Haliotis tuberculata suffer mass mortalities attributed to the bacterium Vibrio harveyi. These mortalities occur at the spawning season, when the abalone immune system is depressed, and when temperatures exceed 17 °C, leading to favorable conditions for V. harveyi proliferation. In order to identify mechanisms of disease resistance, experimental successive infections were carried out on two geographically distinct Brittany populations: one that has suffered recurrent mortalities (Saint-Malo) and one that has not been impacted by the disease (Molène). Furthermore, abalone surviving these two successive bacterial challenges and uninfected abalone were used for several post-infection analyses. The Saint-Malo population was found to be resistant to V. harveyi infection, with a survival rate of 95% compared to 51% for Molène. While in vitro quantification of phagocytosis by flow cytometry showed strong inhibition following the first infection, no inhibition of phagocytosis was observed following the second infection for Saint-Malo, suggesting an immune priming effect. Moreover, assays of phagocytosis of GFP-labelled V. harveyi performed two months post-infection show an inhibition of phagocytosis by extracellular products of V. harveyi for uninfected abalone, while no effect was observed for previously infected abalone from Saint-Malo, suggesting that the effects of immune priming may last upwards of two months. Detection of V. harveyi by qPCR showed that a significantly greater number of abalone from the susceptible population were positive for V. harveyi in the gills, indicating that portal of entry effectors may play a role in resistance to the disease. Collectively, these results suggest a potential synergistic effect of gills and hemolymph in the resistance of H. tuberculata against V. harveyi with an important involvement of the gills, the portal of entry of the bacteria.

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“…A handful of studies have focused on specific memory in invertebrate hostpathogen interactions and found evidence for high degrees of immune priming specificity after infection with various bacterial species in Tribolium castaneum, Bombus terrestris, Bombyx mori and Drosophila melanogaster [4,[7][8][9]. Additionally, a high degree of specificity on the level of parasite genotypes (sibships) was found in a copepod host after repeated exposure to live Schistocephalus solidus tapeworm larvae [10].…”

Section: Introductionmentioning

confidence: 99%

Specificity of oral immune priming in the red flour beetle Tribolium castaneum

Futo¹,

Sell²,

Kutzer³

et al. 2017

Biol. Lett.

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Immune specificity is the degree to which a host's immune system discriminates among various pathogens or antigenic variants. Vertebrate immune memory is highly specific due to antibody responses. On the other hand, some invertebrates show immune priming, i.e. improved survival after secondary exposure to a previously encountered pathogen. Until now, specificity of priming has only been demonstrated via the septic infection route or when live pathogens were used for priming. Therefore, we tested for specificity in the oral priming route in the red flour beetle, For priming, we used pathogen-free supernatants derived from three different strains of the entomopathogen,, which express different Cry toxin variants known for their toxicity against this beetle. Subsequent exposure to the infective spores showed that oral priming was specific for two naturally occurring strains, while a third engineered strain did not induce any priming effect. Our data demonstrate that oral immune priming with a non-infectious bacterial agent can be specific, but the priming effect is not universal across all bacterial strains.

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The specificity of immune priming in silkworm, Bombyx mori, is mediated by the phagocytic ability of granular cells

Cited by 47 publications

References 45 publications

Innate immune memory: An evolutionary perspective

Innate immune memory: An evolutionary perspective

Immune priming and portal of entry effectors improve response to vibrio infection in a resistant population of the European abalone

Specificity of oral immune priming in the red flour beetle Tribolium castaneum

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