In this work we introduce a new measure of dispersion of the eigenvalues of a Hermitian (self-adjoint) compact operator, that we call spectral spread. Then, we obtain several inequalities for unitarily invariant norms involving the spectral spread of self-adjoint compact operators, that are related with Bhatia-Davis's and Corach-Porta-Recht's work on Arithmetic-Geometric mean inequalities, Zhan's inequality for the difference of positive compact operators, Tao's inequalities for anti-diagonal blocks of positive compact operators and Kittaneh's commutator inequalities for positive operators.