The Spectrum and Aetiology of Mycotic Infections from a Tertiary Care Hospital from Western Part of India

HIV related opportunistic fungal infections (OFIs) continue to cause morbidity and mortality in HIV infected patients. The objective for this prospective study is to elucidate the prevalence and spectrum of common OFIs in HIV/AIDS patients in north India. Relevant clinical samples were collected from symptomatic HIV positive patients (n = 280) of all age groups and both sexes and subjected to direct microscopy and fungal culture. Identification as well as speciation of the fungal isolates was done as per the standard recommended methods. CD4+T cell counts were determined by flow cytometry using Fluorescent Activated Cell Sorter Count system. 215 fungal isolates were isolated with the isolation rate of 41.1%. Candida species (86.5%) were the commonest followed by Aspergillus (6.5%), Cryptococcus (3.3%), Penicillium (1.9%), and Alternaria and Rhodotorula spp. (0.9% each). Among Candida species, Candida albicans (75.8%) was the most prevalent species followed by C. tropicalis (9.7%), C. krusei (6.4%), C. glabrata (4.3%), C. parapsilosis (2.7%), and C. kefyr (1.1%). Study demonstrates that the oropharyngeal candidiasis is the commonest among different OFIs and would help to increase the awareness of clinicians in diagnosis and early treatment of these infections helping in the proper management of the patients especially in resource limited countries like ours.

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“…(6.5%) and Cryptococcus spp. (3.3%) which is similar to the various studies as in Table 5 [ 9 – 13 ].…”

Section: Discussionsupporting

confidence: 90%

Spectrum of Opportunistic Fungal Infections in HIV/AIDS Patients in Tertiary Care Hospital in India

Kaur

Dhakad

Goyal

et al. 2016

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…which was not seen in this study. 7 Although the findings of this study match with many studies done across India, it differs significantly with some studies suggesting the role of geographical variation in clinical and mycological pattern. 7…”

Section: Discussionsupporting

confidence: 48%

“…These findings are consistent with Nageshwari et al who also isolated fungus maximally from sputum (58.92%), followed by body fluids (13.98%). 7 In this study males were most commonly affected by fungal infections with male to female ratio being 1.7:1. Similar findings were also seen in studies done by Aggarwal and Nawal et al, who in their study revealed male and female ratio to be 0.74:1 and 2.14:1 respectively.…”

Section: Discussionmentioning

confidence: 60%

Spectrum of fungal infections at a tertiary care hospital in Haryana, India

2018

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Background: In recent years, fungi have been emerging as a common infection in hospitalised patients of tertiary care centres. The climate of our country is well suited for a wide variety of fungal infections. Within the limited data available, an increased incidence of invasive candidiasis, aspergillosis and other dematiaceous fungi are reported at our tertiary care centre. This study was undertaken to know the prevalence of common fungal infections at a tertiary care hospital in a period of five years.Methods: The various clinical samples received from the patients presenting with clinically suspected fungal infections were subjected to direct microscopy with potassium hydroxide (KOH) and Gram staining. All samples were inoculated in duplicate SDA with or without antibiotics.Results: A total of 8450 suspected fungal etiology samples were received during the five years (2011-2015) included in the study. The most common sample was sputum 2502 (29.6%) followed by skin swabs 2175 (25.7%), urine 1302 (15.4%), blood 875 (10.35%) and BAL 810 (9.5%). Male to female ratio was 5:3. Candida albicans was the predominant isolate followed by non-albicans candida, Aspergillus flavus, Aspergillus fumigatus and dematiaceous fungi.Conclusions: The fungal isolates, which used to be discarded as laboratory contaminants are playing a significant role in pathogenicity of many infections. These organisms are now capable of affecting immunocompromised as well as immunocompetent individuals.

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“…Among them Candida tropicalis (26.5%) was the most predominant isolate followed by Candida glabrata (21.7 %), Candida albicans (21.7 %. ), Candida krusei (17.3%) (Table 2; Figure 2).In contrast to the present study, Gandham et al, (2013) reported that Candida albicans (75.8%) was the most prevalent species followed by C. tropicalis and other Candida species whereas the studies made by Picardi et al, (2012) in USA between 2004 and 2009, reported that Candida non-albicans strains were more frequently isolated in HIV/AIDS patients.…”

Section: Fig2 Percentage Of Opportunistic Fungal Pathogens In Hiv/aicontrasting

confidence: 53%

Clinical Profile of opportunistic bacterial and fungal pathogens in HIV/AIDS patients of Thuraiyur region of Tiruchirappalli District, Tamil Nadu, India

Rose¹,

Kumar²,

Xavier³

2017

Int.J.Curr.Res.Aca.Rev.

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Article InfoHuman Immunodeficiency Virus (HIV) infection is leading to AIDS and it is a major threat to human beings. The HIV is not an only thereat but due to associated opportunistic pathogens the major cause of morbidity and mortality is occurring in such patients. Twenty five positive symptomatic patients who are coming to ART centre of Thuraiyur region, Government Hospital of Trichy were included in the present study for finding the profile of opportunistic bacterial and fungal pathogens. Hundred biosamples were collected from 25 clinically symptomatic HIV+ patients during the month of June -December, 2014.Blood serum, sputum, oral swabs and urine samples were collected with taking all aseptic precautions. A total of 73 isolates were identified from 25 HIV infected patients. Among them, seventeen types of bacterial and four types of fungal species were identified. The predominant bacteria isolated in the study were Escherichia coli RV412 and Klebsiella pnemoniae, Escherichia coli DH5 alpha, Enterobacter cloacae MB, Klebsiella pneumonia DSM and Staphylococcus haemolyticus CHB. Similarly in fungal species the most predominant fungus is Candida tropicalis followed by Candida glabrata

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The Spectrum and Aetiology of Mycotic Infections from a Tertiary Care Hospital from Western Part of India

Cited by 5 publications

References 9 publications

Spectrum of Opportunistic Fungal Infections in HIV/AIDS Patients in Tertiary Care Hospital in India

Spectrum of Opportunistic Fungal Infections in HIV/AIDS Patients in Tertiary Care Hospital in India

Spectrum of fungal infections at a tertiary care hospital in Haryana, India

Clinical Profile of opportunistic bacterial and fungal pathogens in HIV/AIDS patients of Thuraiyur region of Tiruchirappalli District, Tamil Nadu, India

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