The Spectrum of Breast Diseases in Nigeria North Central: A Histopathological Survey

Eke, B; Ojo, BA; Akaa, P. Denen; Ahachi, Chukwukadibia N.; Soo, Chung Eul; Adekwu, Amali

doi:10.9734/jamps/2017/32384

Cited by 4 publications

(10 citation statements)

References 9 publications

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“…The most common quadrant involved was upper outer, which included 34.5% of the carcinomas, followed by central quadrant (25.5%), which was comparable to the studies by Anushree et al [14] (upper outer 30% and central 17%), and Jangid et al [13] (upper outer 30.19%). Among the various histological types, the most common in our study was IDC NST (86.4%), which corresponds with studies by Anushree et al [14] (60%), Yogalakshmi et al [11] (77%), Eke et al [15] (88.6%) and Nandam et al [12]. 90.9% cases showed tumor size more than 2 cm, which was close to Ambroise et al study (91.5%) [16].…”

Section: Discussionsupporting

confidence: 91%

Histopathological Spectrum of Breast Carcinoma in a Tertiary Care Centre and its Association with ABO Blood Grouping and Rh Typing

Mitila

Subramanian

Srinivasan

et al. 2021

JPRI

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Background: Globally, breast cancer contributes to 27.7% of the newly diagnosed cases of cancer among women. Early screening and timely diagnosis of the lesions of breast help in alleviating the anxiety among patients. Histopathology is the gold standard in diagnosing the lesions, assessing the adequacy of treatment, and in disease prognosis. Studies have shown that ABO blood type has been associated with risk and survival for several malignancies. However, data for an association with breast cancer are inconsistent. Aim: To study the histopathological spectrum breast carcinomas and to investigate the presence of a possible association between breast cancer in women and ABO blood group and Rh factor. Materials and Methods: This retrospective descriptive study was done for a period of 4 years on 110 mastectomy specimens histopathologically diagnosed as breast cancers, and clinico-pathological data collected and analysed with records from the Department of Pathology, Saveetha Medical College. Association of breast cancer with ABO blood grouping and Rh typing was studied. Results: Left breast was involved in most cases (96.4%). The mean age was 50.86 years, with 41-50 years age group showing peak incidence. Infiltrating breast carcinoma, no special type (89.6%) was the most common histological type. ER and PR positivity was seen in 46.4% and 41.8% of cases respectively. A statistically significant association was seen between hormone receptor status and histological grade. 39.1% cases belonged to O blood group, and Rh positivity was seen in 96.4% of the cases. No association was found between breast cancer and ABO/Rh blood grouping.

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Section: Discussionsupporting

confidence: 91%

Histopathological Spectrum of Breast Carcinoma in a Tertiary Care Centre and its Association with ABO Blood Grouping and Rh Typing

Mitila

Subramanian

Srinivasan

et al. 2021

JPRI

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“…At the national level, only the South-West, South-South and North-Central Nigeria had cases of Paget's disease. Its prevalence in Ogun State (South-West) was higher than that recorded in Delta State (South-South) [13] but lower than that reported in Benue State, North-Central [15]. The prevalence of medullary carcinoma in this study was higher than that reported in Maiduguri [18] and Warri [13] but lower than that reported in Lagos [10], Benin [14] and Zaria [20].…”

Section: Discussioncontrasting

confidence: 73%

“…In this study, the prevalence of breast cancer among other human cancers was lower (40.9%) than the value recorded in Abuja (50.8%) [22] and Osun State (53.2%) [23] and higher than the value reported in Kwara State (22.4%) [24], Borno State (13.9%) [18] and Benue State (8.1%) [15], but comparable with the value recorded in Oyo State (40.8%) [22]. This suggests that females in South-West Nigeria are relatively at a higher risk of developing breast cancer than any other region in Nigeria.…”

Section: Discussioncontrasting

confidence: 71%

“…This suggests that individuals in Ogun State are at low risk of developing medullary carcinoma than its neighbouring South-West State (Lagos State).. Mucinous Carcinoma is a mucin containing breast cancer surrounded by tumor cells [36]. Our study showed low prevalence of mucinous carcinoma in Ogun State compared with that found in other States in Nigeria [10,11,[13][14][15]18,20].…”

Section: Discussionmentioning

confidence: 51%

“…This is in contrast to the findings of Abdulrahman et al [27] who reported highest breast cancer presentations (two-third) among premenopausal women in Africa and among postmenopausal women in Europe. More so, the mean age of breast cancer presentations in Ogun State (50.3%) was higher than that recorded in any Nigerian States [11][12][13][14][15][16][17][18][19][20] and Africa [28].…”

Section: Discussionmentioning

confidence: 88%

See 2 more Smart Citations

Epidemiology of Female Breast Cancer in Ogun State: Intra- and Inter-regional Discuss

Okoye¹,

Erinle²,

Atulomah³

et al. 2017

ujcm

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This study determined the prevalence of breast cancer in relation to age, reproductive status and population of Ogun State. Out of a total of 816 human cancer presentations observed between 2012 and 2016, 334 (40.9%) female breast cancer (with age range= 23 to 95 years and mean age= 50.3 years) were retrospectively reviewed. Result revealed five breast cancer types: Invasive ductal carcinoma (IDC), ductal carcinoma in situ (DCIS), Paget cell disease, medullary carcinoma and mucinous carcinoma. Invasive ductal carcinoma was the predominant breast cancer type (94.9%) while year 2016 had the highest number of breast cancer presentations (47%) at p<0.001). Result also showed that age range of 41-50 years and 61-70 years had the highest prevalence and incidence of breast cancer, respectively (p<0.001). Reproductive age (23-45 years) had the highest frequency of invasive ductal carcinoma and Paget cell disease when compared with other age groups (p<0.001). Result also showed interesting differences in prevalence of breast cancer types in Ogun State compared with other regions.

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Prevalence of basal-like phenotype in triple-negative invasive breast carcinomas and a review of the literature

Obioha,

Kudamnya,

Akpanudo

et al. 2024

AUJMSR

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Objectives: The study is aimed at analyzing the clinico-pathological features and immunohistochemical expression of basal-like phenotype in triple-negative breast carcinomas (TNBC) as well as stratifying of invasive breast carcinomas into main molecular subtypes and correlating the Basal-like breast carcinoma subtype with the size of tumor, grade and age of patient in the University of Uyo Teaching Hospital, Uyo, Akwa Ibom State, Nigeria. Material and Methods: This study was a descriptive cross-sectional hospital-based, that was carried out in the Histopathology Department of the University of Uyo Teaching Hospital, Uyo, Akwa Ibom State, Nigeria, using paraffin-embedded tissue blocks of invasive carcinomas of breast received between July 01, 2016, and August 31, 2018, subject to re-histological assessment and IHC staining for various breast carcinoma markers, including estrogen receptor (ER), progesterone receptor (PR), human epidermal receptor-2 (HER-2), Ki67, epidermal growth factor receptor (EGFR), and CK5/6. The age of patients and tumor size was accessed from the records of the department. The data were analyzed by descriptive and inferential statistics using the Statistical Package for the Social Sciences version 16. Results: A total of 79 histologically confirmed invasive breast carcinomas in females were analyzed. The age range of the patients was 24–76 years, with a mean age of 43.96 ± 9 years. The majority of the invasive carcinomas were of no special type (91.1%). ER, PR, and HER-2 were positive in 53.2%, 32.9%, and 12.7% of cases, respectively. Phenotypic classification based on immunohistochemistry showed that the Luminal A subtype was the predominant subtype, accounting for 45.3% of cases, while Luminal B, HER-2 enriched, basal-like, and unclassified were 13.3%, 5.3%, 17.3%, and 18.7%, respectively. Triple-negative breast carcinomas (TNBCs) accounted for 36.0% of the cases. The frequency of basal-like breast carcinoma in TNBCs was 48.1%. Conclusion: Our study confirmed that the Luminal A subtype of breast carcinomas was the commonest, and there was an appreciable number of the basal-like breast carcinoma subtype in Uyo, with a frequency of 48.1% among the TNBCs.

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The Spectrum of Breast Diseases in Nigeria North Central: A Histopathological Survey

Cited by 4 publications

References 9 publications

Histopathological Spectrum of Breast Carcinoma in a Tertiary Care Centre and its Association with ABO Blood Grouping and Rh Typing

Histopathological Spectrum of Breast Carcinoma in a Tertiary Care Centre and its Association with ABO Blood Grouping and Rh Typing

Epidemiology of Female Breast Cancer in Ogun State: Intra- and Inter-regional Discuss

Prevalence of basal-like phenotype in triple-negative invasive breast carcinomas and a review of the literature

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