The Spectrum of Cholestatic Hepatic Disease

Stauffer, Maurice H.

doi:10.1001/jama.1965.03080100047011

Cited by 50 publications

(21 citation statements)

References 10 publications

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“…It has also been suggested that bile duct carcinoma may be a complication of, or specifically associated with, ulcerative colitis (Boden et al, 1959;Rankin, 1962), and further recent reports appear to support this view (Edwards and Truelove, 1964;Palmer, Kirsner, Goldgraber, and Fuentes, 1964;Stauffer et al, 1965). The three cases recorded in the present paper strengthen the association whatever its nature.…”

supporting

confidence: 77%

“…Obstructive jaundice in patients with ulcerative colitis is usually due to pericholangitis, which develops without blockage to the major bile ducts, and may or may not be accompanied by cirrhosis (Kleckner, Stauffer, Bargen, and Dockerty, 1952;Boden, Rankin, Goulston, and Morrow, 1959;Stauffer, Sauer, Dearing, and Baggenstoss, 1965). The main hepatic lesion in such cases consists of portal and periportal inflammation in which, it has been suggested, the inflammatory changes may originate in either the terminal radicles of the portal vein or the biliary epithelium (Boden et al, 1959;McCarthy and Read, 1962).…”

mentioning

confidence: 99%

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Liver in ulcerative colitis: obstructive jaundice due to bile duct carcinoma.

Rankin¹,

Skyring²,

Goulston³

1966

Gut

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supporting

confidence: 77%

mentioning

confidence: 99%

Liver in ulcerative colitis: obstructive jaundice due to bile duct carcinoma.

Rankin¹,

Skyring²,

Goulston³

1966

Gut

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“…Of 27 cases reported previously, most were found incidentally by autopsy, during cholecystectomy concomitantly performed with colectomy due to UC, or at a late stage requiring liver transplantation. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Although previous authors have warned that gallbladder lesions also develop with a high incidence in PSC patients, such recognition seems not to be remembered sufficiently. 17 This is probably the first report of early GBC in a PSC and UC patient that was found before the operation and curatively resected.…”

Section: Discussionmentioning

confidence: 99%

“…Our literature survey found only 27 GBCs in PSC patients. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] …”

Section: Introductionmentioning

confidence: 99%

Early gallbladder carcinoma associated with primary sclerosing cholangitis and ulcerative colitis

Yamamoto

Uki

Takeuchi

et al. 2003

Journal of Gastroenterology

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Patients troubled with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC) are at high risk for cholangiocarcinoma, whereas cancer of the gallbladder (GBC) is rarely reported to develop in that population. A Japanese man aged 62 years with a 14-year history of PSC and UC had been found to have a protruding lesion of the gallbladder by screening sonography. The preoperative examination suggested the lesion to be GBC at an early stage. Pathology examination after cholecystectomy proved that the lesion was papillary adenocarcinoma localized in the mucosal layer. Although the prognosis of GBC is poor, the outcome of cholecystectomy against early GBC is relatively good. Early detection of the tumor is required for a better prognosis of patients with GBC. According to the review of the literature, PSC and UC patients are regarded as a high-risk group not only for cholangiocarcinoma but also GBC. It is advocated that clinicians perform repeated radiographic examinations including sonography for patients with PSC and UC even if the diseases are being controlled.

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“…Cirrhosis seems to be a more common complication of ulcerative colitis and most reported series of liver dysfunction include some cirrhotic patients and so cannot be compared with the present study [9], Nevertheless, biochemical changes without cirrhosis may occur and may fluctuate with changes in disease activity [28] or remain static. Our findings agree with those of Cohen et al [6] and Perrett et al [23] that liver dysfunction in Crohn's disease does not correlate with disease activity.…”

Section: Discussionmentioning

confidence: 92%

The Incidence and Significance of Liver Dysfunction in Crohn’s Disease

Dyer¹,

Dawson²

1972

Digestion

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26% of 62 patients with Crohn’s disease had elevated serum levels of alkaline phosphatase and 58% of 38 patients showed impaired excretion of BSP; all the patients with hyperphosphatasaemia also showed increased BSP retention. There was no correlation of these tests with other indices of liver function which tended to be normal and no correlation with activity of the disease, duration of symptoms, age of the patient or the serum levels of albumin and cholesterol. Biochemical abnormalities due to liver dysfunction are common and should not be attributed to malabsorption.

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The Spectrum of Cholestatic Hepatic Disease

Cited by 50 publications

References 10 publications

Liver in ulcerative colitis: obstructive jaundice due to bile duct carcinoma.

Liver in ulcerative colitis: obstructive jaundice due to bile duct carcinoma.

Early gallbladder carcinoma associated with primary sclerosing cholangitis and ulcerative colitis

The Incidence and Significance of Liver Dysfunction in Crohn’s Disease

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