The spectrum of chronic inflammatory demyelinating polyneuropathy

Clinical Cases in Pediatric Peripheral Neuropathy

“…A predominantly sensory form is seen in 15% and asymmetry can be seen in just under 10% of patients. Cranial nerves can be involved in 5% of patients and CNS involvement is seen in 8% (Rotta, 2000). The overall course can be relapsing or chronic progressive (Rotta, 2000).…”

“…Cranial nerves can be involved in 5% of patients and CNS involvement is seen in 8% (Rotta, 2000). The overall course can be relapsing or chronic progressive (Rotta, 2000). The initial presentation in general is typically quite striking in children such as gait disturbance and weakness.…”

“…Just under 10% of patients will have caudal root enhancement. Elevated protein in the CSF is seen but not all patients have this (Rotta, 2000). Nearly all CIDP patients will respond to their first treatment within a week.…”

“…60% of patients will respond to IVIG, 70% to steroids, 50% to plasma exchange, and 36% to cytotoxic agents. However, it is not well delineated which of the pediatric patients will have a course of frequent relapsing and partial remitting with treatment (Rotta, 2000). It must be highlighted that early treatment will provide the best opportunity for improvement.…”

CNS Involvement in Chronic Inflammatory Demyelinating Polyneuropathy: A Visual Evoked Potential Study

“…Central nervous system (CNS) involvement has been clinically observed in 5% [1] and 8% [2] of patients and in many cases of CIDP, there is accompanying CNS demyelination with the presence of subclinical electrophysiological and magnetic resonance imaging (MRI) abnormalities [3][4][5]. In an attempt to investigate the possible existence of CNS demyelinating lesions in CIDP patients, we prospectively studied visual evoked potentials (VEPs) in 10 patients.…”