The spectrum of chronic lymphoproliferative disorders in Chinese people

Kwong, Yok Lam; Wong, K. F.; Chan, Li-Chong; Liang, Raymond; Chan, John K.; Wei, Dali; Chiu, E. K. W.; Chan, C. H.; Todd, Dana M.; Chan, TK

doi:10.1002/1097-0142(19940701)74:1<174::aid-cncr2820740128>3.0.co;2-0

Cited by 23 publications

(20 citation statements)

References 21 publications

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“…Despite a lower incidence of CLL in Orientals, (Wong et al 1999;Kwong et al 1994) including an elderly median presenting age and an indolent clinical course (median OS: 96 months). (Keating et al 2003) Moreover, similar to Caucasian patients, advanced Rai stage disease conferred an inferior OS.…”

Section: Discussionmentioning

confidence: 99%

Frequent DAP kinase but not p14 or Apaf-1 hypermethylation in B-cell chronic lymphocytic leukemia

et al. 2006

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Dysregulation of apoptosis, and thus the p14/DAP kinase/HDM2/p53/Apaf-1 pathway, is potentially important in carcinogenesis. Chronic lymphocytic leukemia (CLL), uncommon in the Chinese, is a disease characterized by impaired apoptosis, of the neoplastic lymphocytes. Hypermethylation of p14, DAP kinase and Apaf-1 was studied by methylationspecific polymerase chain reaction (MSP) with primers for methylated (M-MSP) and unmethylated (U-MSP) alleles in 50 diagnostic marrow samples from patients with CLL. Chinese CLL patients had an indolent course similar to Caucasians with median overall survival (OS) of 96 months, which was adversely affected by advanced Rai stage (projected 5-year OS = 72% and 39% for Rai £ 2 and Rai > 2; P = 0.01). DAP kinase was methylated in 18 (36%) patients while p14 and Apaf-1 were completely unmethylated in all the primary CLL samples. There was no correlation between DAP kinase hypermethylation and age, sex, poor-risk karyotype, lymphocyte count and Rai stage at diagnosis. Projected OS for patients with and without DAP kinase hypermethylation were 59 and 57% (P = 0.91). DAP kinase, but not p14 and Apaf-1, of the DAP kinase/p14/HDM2/p53/Apaf-1 pathway is frequently hypermethylated in CLL, but not of prognostic significance. Moreover Chinese patients with CLL share a similarly indolent clinical course, and this is the first comprehensive study on p14, DAP kinase and Apaf-1 hypermethylation in CLL.

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Section: Discussionmentioning

confidence: 99%

Frequent DAP kinase but not p14 or Apaf-1 hypermethylation in B-cell chronic lymphocytic leukemia

et al. 2006

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“…First, the overall frequency of T-LGL leukaemia was 15% in this series from a single tertiary referral centre, which is higher than that reported in our previous multicentre study of Chinese patients with chronic lymphoproliferative disorders (9%). 5 This might be attributable to a diVerence in referral patterns. However, both frequencies are higher than the figure of 2-5% in Western series.…”

Section: Discussionmentioning

confidence: 99%

“…In one Chinese series it accounted for 9% of all chronic lymphoproliferative disorders. 5 It is also thought to be relatively common in the Japanese, 6 although the exact incidence remains undefined. Oriental patients with this condition tend to present with diVerent features from occidental patients-for example, rheumatoid arthritis is very rare but pure red cell aplasia appears to be much more common.…”

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confidence: 99%

“…Oriental patients with this condition tend to present with diVerent features from occidental patients-for example, rheumatoid arthritis is very rare but pure red cell aplasia appears to be much more common. [5][6][7][8] We present the clinicopathological features of five consecutive Chinese patients with T-LGL leukaemia and report a high frequency of pure red cell aplasia in this population.…”

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Association of pure red cell aplasia with T large granular lymphocyte leukaemia

Kwong

Wong

1998

Journal of Clinical Pathology

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Aim-To define the relation between T large granular lymphocyte (T-LGL) leukaemia and pure red cell aplasia in Chinese patients. Methods-Patients with T-LGL leukaemia were identified from a consecutive series of Chinese patients with chronic lymphoproliferative disorders. The diagnosis of T-LGL leukaemia was based on typical morphological and immunophenotypical features, and confirmed by the detection of clonal T cell receptor gene rearrangement. The clinicopathological features, response to treatment, and long term follow up were also examined. Results-Five patients were identified as having T-LGL leukaemia from a consecutive series of 33 Chinese patients with chronic lymphoproliferative disorders. The median follow up time was 45 months. An obvious lymphocytosis was present in only two cases, although an increase in large granular lymphocytes in the peripheral blood was found in four. In one case, the LGL count was within the normal range. Epstein-Barr virus encoded early nuclear RNA was negative in all the cases. There was no evidence of rheumatoid arthritis, and none of the patients presented with recurrent infections. On follow up, pure red cell aplasia occurred at some stage of the disease in all the patients. This responded to treatment with cyclosporin A in two and with antithymocyte globulin in one. Two patients remained transfusion dependent. Conclusions-In contrast to Western patients, Chinese patients with T-LGL leukaemia do not appear to suVer from rheumatoid arthritis and recurrent infections, but pure red cell aplasia is a major cause of morbidity in this ethnic group. (J Clin Pathol 1998;51:672-675)

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“…15 In these countries descriptions of the disorder do not differ substantially from cases reported from the west. However, we have found that in contrast to the situation in Europe and north America, SLVL in Ghana primarily affects middle-aged women.…”

Section: Does Splenic Lymphoma With Villous Lymphocytes Show Geographmentioning

confidence: 84%

Chronic malaria and splenic lymphoma: clues to understanding lymphoma evolution

Bates

Bedu-Addo

1997

Leukemia

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In west Africa, splenic lymphoma with villous lymphocytes and hyper-reactive malarial splenomegaly have many clinical and immunological features in common suggesting an aetiopathological link. We hypothesize that in hyper-reactive malarial splenomegaly the dysregulated immune response to repeated malaria infections results in a stimulated, proliferating pool of B cells in which perturbation of cell growth and apoptosis by environmental and other factors promotes the development of SLVL. In Africa these factors are likely to include infectious agents several of which have already been associated with Bcell non-Hodgkin's lymphomas.

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The spectrum of chronic lymphoproliferative disorders in Chinese people

Cited by 23 publications

References 21 publications

Frequent DAP kinase but not p14 or Apaf-1 hypermethylation in B-cell chronic lymphocytic leukemia

Frequent DAP kinase but not p14 or Apaf-1 hypermethylation in B-cell chronic lymphocytic leukemia

Association of pure red cell aplasia with T large granular lymphocyte leukaemia

Chronic malaria and splenic lymphoma: clues to understanding lymphoma evolution

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