The spectrum of computerized tomography (CT) findings in central nervous system (CNS) infection due to Cryptococcus neoformans var. gattii in immunocompetent children

Corrêa, Maria do Perpétuo Socorro Costa; Severo, Luiz Carlos; Oliveira, Flávio de Mattos; Irion, Klaus; Londero, A. T.

doi:10.1590/s0036-46652002000500010

Cited by 22 publications

(16 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the State of Pará, it an infantile cryptococcal meningitis frequency of 18.6% was verified for 43 cases diagnosed from 2003 to 2007 6 and 24.3% in 78 cases diagnosed from 1992 to 1998 in the same state 3 . A frequency of 33% of cases in children was observed in the State of Amazonas 7 and 21% in the State of Piaui 8 .…”

Section: Introductionmentioning

confidence: 87%

See 1 more Smart Citation

Cryptococcus gattii molecular type VGII as agent of meningitis in a healthy child in Rio de Janeiro, Brazil: report of an autochthonous case

Pinto

Pone

et al. 2010

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Cryptococcus gattii causes meningoencephalitis in immunocompetent hosts, occurring endemically in some tropical and subtropical regions. Recently, this fungus was involved in an outbreak in Vancouver Island and British Columbia (Canada). In this temperate region, the VGII type is predominant. The paper describes an autochthonous case of meningoencephalitis by C. gattii VGII in a previously health child in Rio de Janeiro, considered nonendemic region of Brazil. The fungus was identified by biochemical tests and the molecular type was determined by URA5-RFLP. The present report highlights the need for clinical vigilance for primary cryptococcal meningitis in nonendemic areas.

show abstract

Section: Introductionmentioning

confidence: 87%

“…In a study of tomographic alterations in 11 children with meningitis by C. gattii in the State of Pará, Brazil, all cases presented hypodense nodules, most of them located in the basal ganglia 6 . The same study also described hydrocephalus and diffuse cortical atrophy.…”

Section: Introductionmentioning

confidence: 99%

Cryptococcus gattii molecular type VGII as agent of meningitis in a healthy child in Rio de Janeiro, Brazil: report of an autochthonous case

Pinto

Pone

et al. 2010

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

“…In Brazil, symptoms of headache, fever nuchal rigidity, nausea, and vomiting were common (219,221,256). Cranial CT scans of 11 children with CNS disease revealed hypodense nodules in all patients, cerebral atrophy in 9, hydrocephalus in 6, and hydrocephalus with cerebral atrophy in 5 (220). Meningoencephalitis is also characteristic of most pediatric cases in PNG (218).…”

Section: Clinical Manifestations In Childrenmentioning

confidence: 96%

“…In contrast, concurrent pulmonary and cerebral cryptococcomas and hydrocephalus were more frequently associated with C. gattii independent of host status (27,29). Correa et al reported hypodense nodules on cerebral CT scans, often in the basal ganglia, in all 11 immunocompetent children studied (220). Obstructive hydrocephalus has been described in 17 to 50% of C. gattii infections (27-29, 130, 251).…”

Section: Neurological Infection (I) Computerized Tomographymentioning

confidence: 99%

Cryptococcus gattii Infections

2014

View full text Add to dashboard Cite

SUMMARY Understanding of the taxonomy and phylogeny of Cryptococcus gattii has been advanced by modern molecular techniques. C. gattii probably diverged from Cryptococcus neoformans between 16 million and 160 million years ago, depending on the dating methods applied, and maintains diversity by recombining in nature. South America is the likely source of the virulent C. gattii VGII molecular types that have emerged in North America. C. gattii shares major virulence determinants with C. neoformans , although genomic and transcriptomic studies revealed that despite similar genomes, the VGIIa and VGIIb subtypes employ very different transcriptional circuits and manifest differences in virulence phenotypes. Preliminary evidence suggests that C. gattii VGII causes severe lung disease and death without dissemination, whereas C. neoformans disseminates readily to the central nervous system (CNS) and causes death from meningoencephalitis. Overall, currently available data indicate that the C. gattii VGI, VGII, and VGIII molecular types more commonly affect nonimmunocompromised hosts, in contrast to VGIV. New, rapid, cheap diagnostic tests and imaging modalities are assisting early diagnosis and enabling better outcomes of cerebral cryptococcosis. Complications of CNS infection include increased intracranial pressure, severe neurological sequelae, and development of immune reconstitution syndrome, although the mortality rate is low. C. gattii VGII isolates may exhibit higher fluconazole MICs than other genotypes. Optimal therapeutic regimens are yet to be determined; in most cases, initial therapy with amphotericin B and 5-flucytosine is recommended.

show abstract

“…PAULA et al 69 in a study of the cryptococcosis agent, in 40 cases not associated to infection by HIV, demonstrated the proportion of gattii of about 33% while in AIDS patients this rate is below 1% 51,58,62 . CORREA et al 22 have observed alterations, through tomographical images, in 11 immunocompetent children with infection of the central nervous system (CNS) by gattii variety. In a study carried out in Rio de Janeiro City, patients with AIDS exposed to spores of C. neoformans species in a home environment have presented a risk to cryptococcosis two times more than non-exposed AIDS patients 66 .…”

mentioning

confidence: 99%

Cryptococcosis: a review of the brazilian experience for the disease

Pappalardo

Melhem

2003

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

SUMMARYCryptococcosis is a systemic mycosis caused by Cryptococcus neoformans. The disease occurs in patients with cellular immunodeficiency. The incidence of cryptococcosis arises with AIDS, and mycosis is one of the opportunistic infections that defines AIDS. After the HAART era the occurrence of cryptococcosis decreased all over the world, but it still continues to be a prevalent disease in Brazil. Thus, we consider this paper to be very important as a result of our reviewing of Brazilian literature regarding some relevant aspects of that disease.

show abstract

The spectrum of computerized tomography (CT) findings in central nervous system (CNS) infection due to Cryptococcus neoformans var. gattii in immunocompetent children

Cited by 22 publications

References 12 publications

Cryptococcus gattii molecular type VGII as agent of meningitis in a healthy child in Rio de Janeiro, Brazil: report of an autochthonous case

Cryptococcus gattii molecular type VGII as agent of meningitis in a healthy child in Rio de Janeiro, Brazil: report of an autochthonous case

Cryptococcus gattii Infections

Cryptococcosis: a review of the brazilian experience for the disease

Contact Info

Product

Resources

About