The spectrum of congenital heart diseases in down syndrome

Al-Mendalawi,

doi:10.15537/smj.2016.11.16359

Cited by 3 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Germany, the most frequently observed type of CHD in DS cases is AVSD (51.2%), followed by VSD (25.1%), TOF (6.7%), and ASD (8.9%)[ 7 ]. In Asia, VSD is the most common type of CHD associated with DS, accounting for 43%, followed by AVSD (15.4%), ASD (13.4%), and TOF (13.4%)[ 8 ]. The reasons for these regional differences remain unclear.…”

Section: Discussionmentioning

confidence: 99%

Down syndrome child with multiple heart diseases: A case report

Kong,

Li,

et al. 2023

World J Cardiol

View full text Add to dashboard Cite

BACKGROUND Down syndrome, also known as trisomy 21 syndrome, is commonly associated with congenital heart disease, and can often result in early formation of pulmonary hypertension. The development of pulmonary hypertension can result from factors such as intracardiac and macrovascular shunts, and upper airway obstruction or hypoplasia of lung tissue. Individuals with Down syndrome and congenital heart disease have a significantly lower average life expectancy, with surgical intervention being the most viable treatment option to improve longevity. CASE SUMMARY We report the case of a 13-year-old boy with Down syndrome presenting with atrial septal defect and patent ductus arteriosus along with severe pulmonary hypertension. The electrocardiogram shows sinus rhythm and right ventricular hypertrophy. The echocardiogram shows an atrial septal defect with interrupted echo in the interatrial septum, measuring 0.813 cm in length. The patient was initially refused to be offered surgical treatment by many hospitals due to the high surgical risk and pulmonary artery resistance. After discussing the patient’s diagnosis and treatment options, we ultimately recommended surgical treatment. However, the patient and their family declined this recommendation and chose to be discharged. During the follow-up period of 6 mo, there were no significant improvements or deteriorations in the patient’s condition. CONCLUSION In conclusion, this case highlights the challenges faced by individuals with Down syndrome and congenital heart disease complicated by severe pulmonary hypertension. Timely intervention and a multidisciplinary approach are crucial for improving prognosis and life expectancy. Further research is needed to enhance our understanding and develop effective interventions for this population.

show abstract

Section: Discussionmentioning

confidence: 99%

Down syndrome child with multiple heart diseases: A case report

Kong,

Li,

et al. 2023

World J Cardiol

View full text Add to dashboard Cite

show abstract

“…DS is linked to various chromosomal causes with morphological, biochemical, and physiological consequences (Alaama et al., 2015). In addition to intellectual disability and developmental delays, DS is associated with congenital cardiac abnormalities in more than 50% of newborns, an increased risk of both congenital and acquired thyroid disease, and a higher incidence of conditions such as hearing loss, diabetes, leukemia (Al‐Aama et al., 2012; AlAaraj et al., 2019; Bergström et al., 2016; Manickam et al., 2016), obesity, gastrointestinal disorders, and obstructive sleep apnea syndrome (Basil et al., 2016; Lagan et al., 2020; Saadah et al., 2012). Individuals with DS show varying levels of intellectual disability, and Alzheimer's disease is a significant concern among adults with the condition (Fortea et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

Quality of life in children with Down syndrome and its association with parent and child demographic characteristics: Parent‐reported measures

Alrayes,

Issa,

Alghubayshi

et al. 2023

Molec Gen & Gen Med

View full text Add to dashboard Cite

BackgroundThis study aims to explore the association between the quality of life (QoL) in children with Down syndrome (DS) and its relationship with demographic characteristics of both parents and children. The investigation encompasses five domains: physical and psychological well‐being, autonomy and parental relationship, social well‐being, and peers, as well as school and the learning environment.MethodAn online questionnaire, the KIDSCREEN‐27, was used to measure the QoL of 112 families with DS in Saudi Arabia, referred to as “Parent‐Reported Measures.” Descriptive statistics were analyzed using the Statistical Package for Social Sciences.ResultsThe study found that the QoL of children with DS showed high scores in the psychological well‐being, autonomy, parental relations, school, and learning environment domains. However, the physical and social well‐being and peer domains had lower scores, although still considered “good scores.” Family income had a positively significant influence on all QoL domains. Specifically, higher family income was associated with better QoL outcomes, except for social well‐being. Parental age was found to influence psychological well‐being, while parental education and the relationship between the parent and child influenced social well‐being. Lastly, the child's gender was found to have an impact on the school and learning environment domain.ConclusionThe study highlights the importance of understanding the impact of the demographic variability of children with DS and their parents on the QoL of their children. It emphasizes the need to address the needs of families with lower incomes and the importance of parental education and relationships with their children in improving social well‐being. The findings could aid policymakers and healthcare providers in improving the QoL for families with children who have DS.

show abstract

“…Various types of congenital heart disease (CHD) are frequently diagnosed in children with DS, with an incidence of 40-50% [2]. A much higher prevalence of CHD, almost 86.8%, has been found in Saudi Arabia [3]. Cardiac comorbidities have a significant effect on morbidity and mortality outcomes of DS patients [4], and affect their quality of life [5].…”

Section: Introductionmentioning

confidence: 99%

The Outcome of Congenital Cardiac Surgery in Patients with Down Syndrome: Single-Center Experience

Alnajjar,

Salem,

Baangood

et al. 2023

HSF

View full text Add to dashboard Cite

Objectives: This study aimed to describe the outcomes of Down syndrome patients who underwent cardiac surgery for congenital heart defects and to develop risk prediction models for in-hospital mortality, recurrent hospital admission, and the need for catheter intervention among a cohort of patients. Methods: This single-centre retrospective cohort study included consecutive Down syndrome patients who underwent cardiac surgery for congenital heart defects between January 2018 and December 2021. We reviewed the electronic medical records. Two hundred patients fulfilled the eligibility criteria with complete data reporting. The patients' perioperative data and outcomes were recorded. Results: Females constituted 56.5%. Most (78.5%) patients showed accepted recovery. The incidence of all-cause in-hospital mortality was 3.0%. The rates of the need for a second operation, heart failure management, and permanent pacemaker insertion were 3.0%, 2.0%, and 2.5%, respectively. Only 8 (4.0%) patients stayed in the hospital for a long duration after chylothorax or tracheostomy (if intubated more than 2 weeks). The model had an accuracy of 99% and included the intraoperative transesophageal echocardiography (TEE) abnormalities (residual heart lesions) (adjusted odds ratio [AOR]: 26.541, p = 0.033), the duration of mechanical ventilation following the operation (AOR: 1.152, p = 0.009), and the occurrence of postoperative heart block (AOR: 76.447, p = 0.005). Conclusion: Surgical treatment of congenital heart defects in Down syndrome patients had good outcomes with accepted recovery (without intra-hospital or during follow-up mortality or morbidity) of 78.5% and a 3% incidence of in-hospital mortality. Though, the occurrence of chylothorax was considerably high, and resulted in a long hospital stay (more than 10 days). Repair of tetralogy of Fallot and coarctation of the aorta were associated with an increased likelihood of catheter intervention following the operation.

show abstract

The spectrum of congenital heart diseases in down syndrome

Cited by 3 publications

References 9 publications

Down syndrome child with multiple heart diseases: A case report

Down syndrome child with multiple heart diseases: A case report

Quality of life in children with Down syndrome and its association with parent and child demographic characteristics: Parent‐reported measures

The Outcome of Congenital Cardiac Surgery in Patients with Down Syndrome: Single-Center Experience

Contact Info

Product

Resources

About